EA200801515A1 - Лиганды, которые связывают il-4 и/или il-13 - Google Patents
Лиганды, которые связывают il-4 и/или il-13Info
- Publication number
- EA200801515A1 EA200801515A1 EA200801515A EA200801515A EA200801515A1 EA 200801515 A1 EA200801515 A1 EA 200801515A1 EA 200801515 A EA200801515 A EA 200801515A EA 200801515 A EA200801515 A EA 200801515A EA 200801515 A1 EA200801515 A1 EA 200801515A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- ligands
- bind
- interleukin
- disclosed
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
Abstract
Раскрыты лиганды, которые обладают специфичностью связывания к интерлейкину-4 (IL-4), к интерлейкину-13 (IL-13) или к IL-4 и IL-13. Также раскрыты способы применения этих лигандов. В частности, описано применение этих лигандов для лечения аллергической астмы.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76170806P | 2006-01-24 | 2006-01-24 | |
PCT/GB2007/000228 WO2007085815A2 (en) | 2006-01-24 | 2007-01-24 | Ligands that bind il-4 and/or il-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200801515A1 true EA200801515A1 (ru) | 2009-02-27 |
Family
ID=38028503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200801515A EA200801515A1 (ru) | 2006-01-24 | 2007-01-24 | Лиганды, которые связывают il-4 и/или il-13 |
Country Status (16)
Country | Link |
---|---|
US (3) | US20110159003A1 (ru) |
EP (1) | EP1976882A2 (ru) |
JP (2) | JP2009523460A (ru) |
KR (1) | KR20080098382A (ru) |
CN (1) | CN101578298A (ru) |
AU (1) | AU2007209202A1 (ru) |
BR (1) | BRPI0710572A2 (ru) |
CA (1) | CA2636854A1 (ru) |
CR (1) | CR10179A (ru) |
EA (1) | EA200801515A1 (ru) |
IL (1) | IL192572A0 (ru) |
MA (1) | MA30175B1 (ru) |
NO (1) | NO20082942L (ru) |
TW (2) | TW200804593A (ru) |
WO (1) | WO2007085815A2 (ru) |
ZA (1) | ZA200806202B (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2694980C2 (ru) * | 2014-04-11 | 2019-07-18 | Новартис Аг | Способы избирательного лечения астмы с использованием антагонистов il-13 |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ567124A (en) | 2005-10-21 | 2011-08-26 | Novartis Ag | Human antibodies against Interleukin-13 and therapeutic uses to treat asthma |
WO2009138413A1 (en) * | 2008-05-15 | 2009-11-19 | Domantis Limited | Single domain antibodies that bind il-13 |
WO2007134050A2 (en) * | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
WO2009030285A1 (en) * | 2007-09-07 | 2009-03-12 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
EP2036980A1 (de) * | 2007-09-14 | 2009-03-18 | Gruber, Jens | Herabregulation der Genexpression mittels Nukleinsäure-beladener virusähnlicher Partikel |
AU2017201007B2 (en) * | 2007-10-15 | 2018-12-13 | Sanofi | Antibodies that bind IL-4 and/or IL-13 and their uses |
EP2050764A1 (en) * | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
CA2707986A1 (en) * | 2007-12-13 | 2009-06-18 | Glaxo Group Limited | Compositions for pulmonary delivery |
US9181327B2 (en) | 2008-01-07 | 2015-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-HIV domain antibodies and method of making and using same |
KR102070761B1 (ko) * | 2008-03-31 | 2020-01-29 | 제넨테크, 인크. | 천식을 치료 및 진단하기 위한 조성물 및 방법 |
AU2009237662A1 (en) | 2008-04-17 | 2009-10-22 | Ablynx N.V. | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
DK2334705T3 (en) * | 2008-09-26 | 2017-03-27 | Ucb Biopharma Sprl | BIOLOGICAL PRODUCTS |
KR20110071139A (ko) * | 2008-10-21 | 2011-06-28 | 도만티스 리미티드 | Dcsign에 대한 결합 특이성을 갖는 리간드 |
BRPI0919881B1 (pt) | 2008-10-31 | 2021-09-08 | Centocor Ortho Biotech Inc | Proteína de arcabouço e seu método de geração, biblioteca e seu método de construção, molécula de ácido nucleico, vetor de ácido nucleico, célula hospedeira, composição, dispositivo médico e artigo de fabricação |
WO2010060486A1 (en) * | 2008-11-26 | 2010-06-03 | Glaxo Group Limited | Ligands that bind il-13 |
US8858940B2 (en) | 2008-12-10 | 2014-10-14 | Ablynx N.V. | Amino acid sequences directed against the Angiopoietin/Tie system and polypeptides comprising the same for the treatment of diseases and disorders related to angiogenesis |
UY32664A (es) * | 2009-05-28 | 2010-12-31 | Glaxo Group Ltd | Nuevas inmunoglobulinas que se enlazan con interleuquinas |
WO2010136483A2 (en) * | 2009-05-28 | 2010-12-02 | Glaxo Group Limited | Antigen-binding proteins |
KR20120038494A (ko) * | 2009-07-16 | 2012-04-23 | 글락소 그룹 리미티드 | 개선된 항-혈청 알부민 결합 단일 가변 도메인 |
EA026097B1 (ru) * | 2009-07-29 | 2017-03-31 | Глаксо Груп Лимитед | Однодоменные антитела против рецептора tgf-бета ii типа |
EP2531523A1 (en) | 2010-02-05 | 2012-12-12 | Ablynx N.V. | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
HUE044292T2 (hu) * | 2010-02-11 | 2019-10-28 | Ablynx Nv | Eljárások és készítmények aeroszolok elõállítására |
ES2923567T3 (es) | 2010-04-30 | 2022-09-28 | Janssen Biotech Inc | Composiciones del dominio de fibronectina estabilizadas, métodos y usos |
MX2013007936A (es) | 2011-01-06 | 2013-08-09 | Glaxo Group Ltd | Ligandos que se unen al receptor ii del factor de crecimiento transformante-beta. |
AR085911A1 (es) | 2011-03-16 | 2013-11-06 | Sanofi Sa | Dosis terapeutica segura de una proteina similar a un anticuerpo con region v dual |
US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
PT2699601T (pt) | 2011-04-21 | 2018-04-05 | Domantis Ltd | Polipéptidos de anticorpo que antagonizam cd40 |
KR102142385B1 (ko) | 2011-09-27 | 2020-08-10 | 얀센 바이오테크 인코포레이티드 | 대체 결합 표면을 가진 피브로넥틴 유형 iii 반복체 기반의 단백질 스캐폴드 |
US10481164B2 (en) * | 2012-03-26 | 2019-11-19 | Amgen Inc. | Method for using light scattering in real time to directly monitor and control impurity removal in purification processes |
US9127053B2 (en) | 2012-06-22 | 2015-09-08 | Cytomx Therapeutics, Inc. | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
PL3470432T3 (pl) | 2012-08-21 | 2022-02-07 | Sanofi Biotechnology | Sposoby leczenia lub zapobiegania astmie przez podawanie antagonisty IL-4R |
WO2014030780A1 (en) * | 2012-08-22 | 2014-02-27 | Mogam Biotechnology Research Institute | Screening and engineering method of super-stable immunoglobulin variable domains and their uses |
US11066467B2 (en) | 2013-12-17 | 2021-07-20 | Mhs Care-Innovation Llc | Compositions and methods for treating ischemic heart disease |
RU2711478C2 (ru) * | 2013-12-17 | 2020-01-17 | ЭмЭйчЭс КЕА-ИННОВЕЙШН ЭлЭлСи | Композиции и способы борьбы с накоплением жировой ткани |
CN106232140A (zh) * | 2014-02-21 | 2016-12-14 | 赛诺菲生物技术公司 | 通过施用il‑4r拮抗剂治疗或预防哮喘的方法 |
EP3113796A1 (en) | 2014-03-07 | 2017-01-11 | Bristol-Myers Squibb Company | Method of using antibody polypeptides that antagonize cd40 to treat ibd |
SI3204095T1 (sl) | 2014-10-10 | 2019-08-30 | Ablynx N.V. | Inhalacijska naprava za uporabo pri zdravljenju bolezni dihal z aerosolom |
WO2016055656A1 (en) | 2014-10-10 | 2016-04-14 | Ablynx N.V. | Methods of treating rsv infections |
US10066017B2 (en) | 2014-11-14 | 2018-09-04 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an IL-4R antagonist |
US11426468B2 (en) | 2014-12-19 | 2022-08-30 | Ablynx N.V. | Cysteine linked nanobody dimers |
AU2017259876A1 (en) | 2016-05-02 | 2018-10-25 | Ablynx Nv | Treatment of RSV infection |
JP6293829B2 (ja) * | 2016-08-05 | 2018-03-14 | モガム インスティチュート フォー バイオメディカル リサーチMOGAM Institute for Biomedical Research | 安定化された免疫グロブリン可変ドメイン選別方法及び選別されたドメインの応用 |
WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
US10611823B2 (en) | 2016-12-14 | 2020-04-07 | Hanssen Biotech, Inc | CD137 binding fibronectin type III domains |
US10597438B2 (en) | 2016-12-14 | 2020-03-24 | Janssen Biotech, Inc. | PD-L1 binding fibronectin type III domains |
AU2017378226A1 (en) | 2016-12-14 | 2019-06-20 | Janssen Biotech, Inc. | CD8A-binding fibronectin type III domains |
JP7315545B2 (ja) | 2017-10-30 | 2023-07-26 | サノフィ・バイオテクノロジー | Il-4r拮抗薬の投与により喘息を処置または予防するための方法 |
CN108855003B (zh) * | 2018-06-28 | 2021-01-05 | 南开大学 | 一种用于清除血液中炎性因子的免疫吸附剂及其制备方法 |
CN111514292B (zh) | 2018-12-25 | 2023-06-20 | 江苏荃信生物医药股份有限公司 | 抗人白介素4受体α单克隆抗体的制药用途 |
EP3930754A4 (en) * | 2019-02-27 | 2023-08-16 | Zhejiang Nanomab Technology Center Co. Ltd. | HIGH-THROUGHPUT SEQUENCE-BASED PROCEDURE FOR GENERATION OF CAMELID ANTIBODIES TO COVER WIDE EPITOPES WITH HIGH RESOLUTION |
US11628222B2 (en) | 2019-10-14 | 2023-04-18 | Aro Biotherapeutics Company | CD71 binding fibronectin type III domains |
US11781138B2 (en) | 2019-10-14 | 2023-10-10 | Aro Biotherapeutics Company | FN3 domain-siRNA conjugates and uses thereof |
US20230279115A1 (en) | 2020-04-22 | 2023-09-07 | Mabwell (shanghai) Bioscience Co., Ltd. | Single variable domain antibody targeting human programmed death ligand 1 (pd-l1) and derivative thereof |
JP2023524997A (ja) * | 2020-05-06 | 2023-06-14 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Clec12aを標的とする抗体及びその使用 |
US20240117030A1 (en) * | 2022-03-03 | 2024-04-11 | Pfizer Inc. | Multispecific antibodies and uses thereof |
WO2024038112A1 (en) * | 2022-08-17 | 2024-02-22 | Institut National de la Santé et de la Recherche Médicale | Improved anti-albumin nanobodies and their uses |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
US5637481A (en) * | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
ATE171472T1 (de) * | 1992-02-19 | 1998-10-15 | Schering Corp | Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4 |
US5596072A (en) * | 1992-08-21 | 1997-01-21 | Schering Corporation | Method of refolding human IL-13 |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
US7175988B2 (en) * | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
SI1517921T1 (sl) * | 2002-06-28 | 2006-10-31 | Domantis Ltd | Dvojno-specificni ligandi z zvisano serumsko razpolovno dobo |
CA2511910A1 (en) * | 2002-12-27 | 2004-07-15 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
SG10201404273QA (en) * | 2003-12-23 | 2014-10-30 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
US7410781B2 (en) * | 2004-02-27 | 2008-08-12 | Regeneron Pharmaceuticals, Inc. | IL-4/IL-13 specific polypeptides and therapeutic uses thereof |
AR049390A1 (es) * | 2004-06-09 | 2006-07-26 | Wyeth Corp | Anticuerpos contra la interleuquina-13 humana y usos de los mismos |
TWI307630B (en) * | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
JP2008510015A (ja) * | 2004-08-16 | 2008-04-03 | セラヴァンス, インコーポレーテッド | β2アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
-
2007
- 2007-01-24 TW TW096102778A patent/TW200804593A/zh unknown
- 2007-01-24 CN CNA2007800097556A patent/CN101578298A/zh active Pending
- 2007-01-24 US US12/223,005 patent/US20110159003A1/en not_active Abandoned
- 2007-01-24 AU AU2007209202A patent/AU2007209202A1/en not_active Abandoned
- 2007-01-24 EA EA200801515A patent/EA200801515A1/ru unknown
- 2007-01-24 EP EP07705003A patent/EP1976882A2/en not_active Withdrawn
- 2007-01-24 KR KR1020087020811A patent/KR20080098382A/ko not_active Application Discontinuation
- 2007-01-24 CA CA002636854A patent/CA2636854A1/en not_active Abandoned
- 2007-01-24 JP JP2008551864A patent/JP2009523460A/ja active Pending
- 2007-01-24 JP JP2008551863A patent/JP2009523459A/ja active Pending
- 2007-01-24 TW TW096102774A patent/TW200740843A/zh unknown
- 2007-01-24 BR BRPI0710572-0A patent/BRPI0710572A2/pt not_active IP Right Cessation
- 2007-01-24 WO PCT/GB2007/000228 patent/WO2007085815A2/en active Application Filing
-
2008
- 2008-05-15 US US12/152,903 patent/US20090060916A1/en not_active Abandoned
- 2008-07-02 NO NO20082942A patent/NO20082942L/no not_active Application Discontinuation
- 2008-07-02 IL IL192572A patent/IL192572A0/en unknown
- 2008-07-16 ZA ZA200806202A patent/ZA200806202B/xx unknown
- 2008-07-24 CR CR10179A patent/CR10179A/es unknown
- 2008-07-25 MA MA31143A patent/MA30175B1/fr unknown
-
2009
- 2009-05-13 US US12/992,718 patent/US20120093830A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2694980C2 (ru) * | 2014-04-11 | 2019-07-18 | Новартис Аг | Способы избирательного лечения астмы с использованием антагонистов il-13 |
Also Published As
Publication number | Publication date |
---|---|
MA30175B1 (fr) | 2009-01-02 |
TW200804593A (en) | 2008-01-16 |
IL192572A0 (en) | 2009-02-11 |
EP1976882A2 (en) | 2008-10-08 |
WO2007085815A2 (en) | 2007-08-02 |
CR10179A (es) | 2008-10-29 |
NO20082942L (no) | 2008-10-15 |
JP2009523460A (ja) | 2009-06-25 |
AU2007209202A1 (en) | 2007-08-02 |
CN101578298A (zh) | 2009-11-11 |
US20110159003A1 (en) | 2011-06-30 |
US20090060916A1 (en) | 2009-03-05 |
US20120093830A1 (en) | 2012-04-19 |
ZA200806202B (en) | 2009-11-25 |
CA2636854A1 (en) | 2007-08-02 |
BRPI0710572A2 (pt) | 2013-01-08 |
TW200740843A (en) | 2007-11-01 |
WO2007085815A3 (en) | 2007-11-15 |
JP2009523459A (ja) | 2009-06-25 |
WO2007085815A8 (en) | 2008-07-31 |
KR20080098382A (ko) | 2008-11-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200801515A1 (ru) | Лиганды, которые связывают il-4 и/или il-13 | |
EA200700175A1 (ru) | Композиции и способы лечения воспалительных заболеваний | |
CY1120887T1 (el) | Αντισωματα που προσδενουν il-4 και/ή il-13 και οι χρησεις τους | |
MX2009006471A (es) | Anticuerpo anti especifico de linfopoyetina estromal timica de diseño. | |
MY169746A (en) | Dual variable domain immunoglobulin and uses thereof | |
MY162511A (en) | Engineered anti-tslp antibody | |
CR20140465A (es) | Proteinas de union a interleuquina-13 | |
DK1749029T3 (da) | Bindemolekyler, der kan neutralisere rabiesvirus, og anvendelser deraf | |
MX2010008688A (es) | Anticuerpos anti-receptor de linfopoyetina estromal timica procesados por ingenieria. | |
EA200870274A1 (ru) | ПЕПТИДЫ, БЛОКИРУЮЩИЕ СВЯЗЫВАНИЕ IgG C FcRn | |
MX2009010765A (es) | Anticuerpos anti-ige. | |
NZ599875A (en) | Human il-23 antigen binding proteins | |
MX2010002269A (es) | Composiciones y metodos que comprenden proteinas de union para adalimumab. | |
NZ583361A (en) | Peptides for desensibilization against allergens | |
WO2009111508A3 (en) | Metalloproteinase 9 and metalloproteinase 2 binding proteins | |
WO2009111450A3 (en) | Metalloproteinase 9 binding proteins | |
NO20092637L (no) | Fremgangsmater for behandling | |
NO20085422L (no) | Bindingsproteiner for hepatocyttvekstfaktor (HGF) | |
NO20085421L (no) | Bindingsproteiner for hepatocyttvekstfaktor (HGF) | |
TW201129377A (en) | Binding proteins that bind to human FGFR1c, human β-Klotho and both human FGFR1c and human β-Klotho | |
MX2009009283A (es) | Anticuerpos anti-interleuquina -23r de ingenieria. | |
NO20083066L (no) | Antistoffmolekyler med spesifisitet for human-IL-6 | |
WO2010021874A3 (en) | Engineered anti-il-13 antibodies, compositions, methods and uses | |
IL187321A0 (en) | Host cell specific binding molecules capable of neutralizing viruses and uses thereof | |
EA200901421A1 (ru) | Антитела к il-25 |