EA200702609A1 - Полипептиды - Google Patents

Полипептиды

Info

Publication number
EA200702609A1
EA200702609A1 EA200702609A EA200702609A EA200702609A1 EA 200702609 A1 EA200702609 A1 EA 200702609A1 EA 200702609 A EA200702609 A EA 200702609A EA 200702609 A EA200702609 A EA 200702609A EA 200702609 A1 EA200702609 A1 EA 200702609A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polypeptide
rmhc
seq
class
specified
Prior art date
Application number
EA200702609A
Other languages
English (en)
Inventor
Бент Карстен Якобсен
Йи Ли
Рут Карен Мойсей
Original Assignee
Медиджен Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Медиджен Лимитед filed Critical Медиджен Лимитед
Publication of EA200702609A1 publication Critical patent/EA200702609A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение предусматривает полипептиды, обладающие свойством связывания с данным рМНС Класса I, отличающиеся тем, что величина Kуказанного полипептида в отношении указанного заданного рМНС Класса I ниже или равна 1 мкМ, и/или скорость диссоциации (k) для указанного рМНС Класса I составляет 2 сили менее, и идентичность указанного полипептида с SEQ ID NO: 7 составляет 45% и/или сходство (подобие) его с SEQ ID NO: 7 составляет 55%, и указанный полипептид ингибирует связывание CD 8 с данным рМНС в более высокой степени, чем полипептид SEQ ID NO: 3. Такие полипептиды пригодны, например, либо самостоятельно, либо в сочетании с терапевтическим агентом, для ингибирования реакций цитотоксических клеток (CTL).
EA200702609A 2005-05-25 2006-05-19 Полипептиды EA200702609A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0510627.3A GB0510627D0 (en) 2005-05-25 2005-05-25 Polypeptides
PCT/GB2006/001860 WO2006125963A2 (en) 2005-05-25 2006-05-19 Modified leukocyte ig-like receptor family members (lir' s) with increased affinity for class i mhc and their uses in modulating t cell activation

Publications (1)

Publication Number Publication Date
EA200702609A1 true EA200702609A1 (ru) 2008-10-30

Family

ID=34834594

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702609A EA200702609A1 (ru) 2005-05-25 2006-05-19 Полипептиды

Country Status (15)

Country Link
US (1) US8092807B2 (ru)
EP (1) EP1885752B1 (ru)
JP (1) JP2008545404A (ru)
CN (1) CN101268100A (ru)
AT (1) ATE473240T1 (ru)
AU (1) AU2006250976A1 (ru)
BR (1) BRPI0611167A2 (ru)
CA (1) CA2609447A1 (ru)
DE (1) DE602006015306D1 (ru)
EA (1) EA200702609A1 (ru)
ES (1) ES2348674T3 (ru)
GB (1) GB0510627D0 (ru)
MX (1) MX2007014585A (ru)
WO (1) WO2006125963A2 (ru)
ZA (1) ZA200709924B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
WO2008062147A1 (en) 2006-11-24 2008-05-29 Medigene Limited ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES
WO2009060159A1 (en) * 2007-11-08 2009-05-14 Medigene Limited Mutated ilt molecules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338283T3 (es) 1996-12-06 2010-05-05 Schering Corporation Genes encontrados de celulas monociticas de mamiferos; reactivos relacionados.
US6384203B1 (en) * 1999-05-12 2002-05-07 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
US6448035B1 (en) * 1997-04-24 2002-09-10 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR)
GB9722779D0 (en) 1997-10-28 1997-12-24 Isis Innovation Human CD8 as an inhibitor of the cellular immune system
EP1066380B1 (en) 1998-05-19 2001-11-14 Avidex Ltd Soluble t cell receptor
JP2004524001A (ja) 2000-01-25 2004-08-12 ハイセック，インコーポレーテッド 白血球免疫グロブリン受容体（ｌｉｒ様）ポリペプチドおよびポリヌクレオチドに関する方法と材料
EP1453540A4 (en) 2001-11-14 2005-06-01 Immunex Corp MODULATION OF THE LIR FUNCTION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
JP2006515747A (ja) 2002-11-01 2006-06-08 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
WO2005058953A2 (en) 2003-12-12 2005-06-30 Regeneron Pharmaceuticals, Inc. Ogh fusion polypeptides and therapeutic uses thereof
JP2008504012A (ja) 2004-01-28 2008-02-14 シントニックス・ファーマシューティカルズ・インコーポレーテッド 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Ｆｃ（ＦＳＨ−Ｆｃ）融合タンパク質
GB0411773D0 (en) 2004-05-26 2004-06-30 Avidex Ltd Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex
US8207110B2 (en) 2004-09-03 2012-06-26 The Trustees Of Columbia University In The City Of New York ITL3 polypeptides and uses thereof
WO2008062147A1 (en) 2006-11-24 2008-05-29 Medigene Limited ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES

Also Published As

Publication number Publication date
MX2007014585A (es) 2008-04-22
US20090208447A1 (en) 2009-08-20
ATE473240T1 (de) 2010-07-15
EP1885752A2 (en) 2008-02-13
CA2609447A1 (en) 2006-11-30
ZA200709924B (en) 2009-03-25
DE602006015306D1 (de) 2010-08-19
AU2006250976A1 (en) 2006-11-30
GB0510627D0 (en) 2005-06-29
ES2348674T3 (es) 2010-12-10
WO2006125963A2 (en) 2006-11-30
JP2008545404A (ja) 2008-12-18
CN101268100A (zh) 2008-09-17
BRPI0611167A2 (pt) 2010-08-17
WO2006125963A3 (en) 2008-04-17
EP1885752B1 (en) 2010-07-07
US8092807B2 (en) 2012-01-10

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