DE602005025989D1 - Von 2',3'-didesoxynucleosiden und 2',3'-didehydro-2',3'-didesoxynucleosiden - Google Patents

Von 2',3'-didesoxynucleosiden und 2',3'-didehydro-2',3'-didesoxynucleosiden

Info

Publication number
DE602005025989D1
DE602005025989D1 DE602005025989T DE602005025989T DE602005025989D1 DE 602005025989 D1 DE602005025989 D1 DE 602005025989D1 DE 602005025989 T DE602005025989 T DE 602005025989T DE 602005025989 T DE602005025989 T DE 602005025989T DE 602005025989 D1 DE602005025989 D1 DE 602005025989D1
Authority
DE
Germany
Prior art keywords
seq
didesoxynucleosides
transferases
analogues
deoxyribosyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005025989T
Other languages
English (en)
Inventor
Pierre-Alexandre Kaminski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Original Assignee
Institut Pasteur de Lille
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille filed Critical Institut Pasteur de Lille
Publication of DE602005025989D1 publication Critical patent/DE602005025989D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005025989T 2004-03-30 2005-03-29 Von 2',3'-didesoxynucleosiden und 2',3'-didehydro-2',3'-didesoxynucleosiden Active DE602005025989D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403319A FR2868432B1 (fr) 2004-03-30 2004-03-30 N-desoxyribosyltransferases de lactobacillus fermantum et application a la synthese enzymatique de 2',3'-didesoxynucleosides et de 2'3'-didehydro- 2'3'-didesoxynucleosides
PCT/FR2005/000743 WO2005095596A1 (fr) 2004-03-30 2005-03-29 N-desoxyribosyltransferases de lactobacillus fermentum et application a la synthese enzymatique de 2’, 3’ -didesoxynucleoside et de 2’,3’-didehydro-2’, 3’-didesoxynucleosides

Publications (1)

Publication Number Publication Date
DE602005025989D1 true DE602005025989D1 (de) 2011-03-03

Family

ID=34945835

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005025989T Active DE602005025989D1 (de) 2004-03-30 2005-03-29 Von 2',3'-didesoxynucleosiden und 2',3'-didehydro-2',3'-didesoxynucleosiden

Country Status (8)

Country Link
US (1) US7820795B2 (de)
EP (1) EP1730275B1 (de)
JP (1) JP4690390B2 (de)
AT (1) ATE496121T1 (de)
BR (1) BRPI0509293A (de)
DE (1) DE602005025989D1 (de)
FR (1) FR2868432B1 (de)
WO (1) WO2005095596A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102000927B1 (ko) * 2017-09-29 2019-07-17 에스티팜 주식회사 N-데옥시리보실 트랜스퍼라아제 변이체 및 이를 이용한 뉴클레오시드의 제조방법
CN109295026B (zh) * 2018-10-18 2021-08-24 清华大学 一种n-脱氧核糖转移酶ii定向进化改造和生物催化应用
CN110819604B (zh) * 2019-12-05 2021-07-27 上海兆维科技发展有限公司 脱氧核糖转移酶突变体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823219B1 (fr) * 2001-04-10 2003-07-04 Pasteur Institut Mutants de la desoxycytidine kinase possedant une activite enzymatique elargie
FR2829774B1 (fr) * 2001-09-14 2004-09-03 Pasteur Institut N-desoxyribosyltransferases de lactobacilles, sequences nucleotidiques correspondantes et leurs applications
US7381555B2 (en) * 2001-09-14 2008-06-03 Institut Pasteur Lactobacillus N-deoxyribosyl transferases, corresponding nucleotide sequences and their uses
FR2852968B1 (fr) * 2003-03-28 2007-10-26 Pasteur Institut Procede de modification in vivo de l'activite de synthese d'un metabolite par modification d'un gene dont l'activite n'est pas l'activite originelle

Also Published As

Publication number Publication date
WO2005095596A1 (fr) 2005-10-13
US20080064646A1 (en) 2008-03-13
ATE496121T1 (de) 2011-02-15
FR2868432A1 (fr) 2005-10-07
FR2868432B1 (fr) 2007-11-02
JP4690390B2 (ja) 2011-06-01
EP1730275B1 (de) 2011-01-19
JP2007530067A (ja) 2007-11-01
US7820795B2 (en) 2010-10-26
EP1730275A1 (de) 2006-12-13
BRPI0509293A (pt) 2007-09-18

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