MX2021000323A - Enzimas de variante de pantotenato quinasa modificadas geneticamente. - Google Patents

Enzimas de variante de pantotenato quinasa modificadas geneticamente.

Info

Publication number
MX2021000323A
MX2021000323A MX2021000323A MX2021000323A MX2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A
Authority
MX
Mexico
Prior art keywords
enzymes
pank
pantothenate kinase
present
engineered pantothenate
Prior art date
Application number
MX2021000323A
Other languages
English (en)
Inventor
Oscar Alvizo
Nandhitha Subramanian
Agustina Rodriguez-Granillo
Grant Murphy
Margie Tabuga Borra-Garske
Lillian Jasmine Miller
Jessie B Slaton
Aksiniya Lyubenova Petkova
Joshua Kolev
Anna Fryszkowska
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of MX2021000323A publication Critical patent/MX2021000323A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01033—Pantothenate kinase (2.7.1.33)

Abstract

La presente invención proporciona enzimas pantotenato quinasa (PanK) modificadas genéticamente, polipéptidos que tienen actividad PanK y polinucleótidos que codifican estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; también se proporcionan métodos para producir enzimas PanK; la presente invención proporciona además composiciones que comprenden las enzimas PanK y métodos para usar las enzimas PanK modificadas genéticamente; la presente invención encuentra un uso particular en la producción de compuestos farmacéuticos.
MX2021000323A 2018-07-09 2019-07-02 Enzimas de variante de pantotenato quinasa modificadas geneticamente. MX2021000323A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862695587P 2018-07-09 2018-07-09
US201962822301P 2019-03-22 2019-03-22
PCT/US2019/040379 WO2020014050A1 (en) 2018-07-09 2019-07-02 Engineered pantothenate kinase variant enzymes

Publications (1)

Publication Number Publication Date
MX2021000323A true MX2021000323A (es) 2021-03-25

Family

ID=69101223

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021000323A MX2021000323A (es) 2018-07-09 2019-07-02 Enzimas de variante de pantotenato quinasa modificadas geneticamente.

Country Status (11)

Country Link
US (2) US10889806B2 (es)
EP (1) EP3820991A4 (es)
JP (1) JP2021530216A (es)
KR (1) KR20210031929A (es)
CN (1) CN112673091A (es)
AU (1) AU2019300838A1 (es)
CA (1) CA3103819A1 (es)
IL (1) IL279884A (es)
MX (1) MX2021000323A (es)
SG (1) SG11202012136YA (es)
WO (1) WO2020014050A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202012136YA (en) * 2018-07-09 2021-01-28 Codexis Inc Engineered pantothenate kinase variant enzymes
CN112996511A (zh) * 2018-07-09 2021-06-18 默沙东公司 4’-乙炔基核苷类似物的酶促合成
MX2021015613A (es) * 2019-07-02 2022-02-03 Codexis Inc Enzimas variantes acetato cinasa dise?adas.
EP4222252A1 (en) * 2020-10-02 2023-08-09 Codexis, Inc. Engineered pantothenate kinase variant enzymes

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US20060257890A1 (en) 1996-05-20 2006-11-16 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6406855B1 (en) 1994-02-17 2002-06-18 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6165793A (en) 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6395547B1 (en) 1994-02-17 2002-05-28 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
DK0765394T3 (da) 1994-06-03 2001-12-10 Novozymes As Oprensede Myceliopthora-laccaser og nukleinsyrer der koder for disse
AU2705895A (en) 1994-06-30 1996-01-25 Novo Nordisk Biotech, Inc. Non-toxic, non-toxigenic, non-pathogenic fusarium expression system and promoters and terminators for use therein
FI104465B (fi) 1995-06-14 2000-02-15 Valio Oy Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö
US6506602B1 (en) 1996-03-25 2003-01-14 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
WO1998031816A1 (en) 1997-01-17 1998-07-23 Regents Of The University Of Minnesota Dna molecules and protein displaying improved triazine compound degrading ability
EP1717322B1 (en) 1997-01-17 2012-07-18 Codexis Mayflower Holdings, LLC Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US6537746B2 (en) 1997-12-08 2003-03-25 Maxygen, Inc. Method for creating polynucleotide and polypeptide sequences
JP2002510506A (ja) 1998-04-02 2002-04-09 テラス ジェネティック リソーシズ，インコーポレイティド 遺伝子配列に遺伝障害を有する植物を得る方法
US6500617B1 (en) 1998-05-01 2002-12-31 Maxygen, Inc. Optimization of pest resistance genes using DNA shuffling
JP2002517995A (ja) 1998-06-17 2002-06-25 マキシジェン， インコーポレイテッド 所望の特性を有するポリヌクレオチドを生成するための方法
US6365408B1 (en) 1998-06-19 2002-04-02 Maxygen, Inc. Methods of evolving a polynucleotides by mutagenesis and recombination
US6605430B1 (en) 1998-08-12 2003-08-12 Maxygen, Inc. DNA shuffling of monooxygenase genes for production of industrial chemicals
CA2345203A1 (en) 1998-10-07 2000-04-13 Maxygen Inc. Dna shuffling to produce nucleic acids for mycotoxin detoxification
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
JP4221100B2 (ja) 1999-01-13 2009-02-12 エルピーダメモリ株式会社 半導体装置
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US7873477B1 (en) 2001-08-21 2011-01-18 Codexis Mayflower Holdings, Llc Method and system using systematically varied data libraries
ATE465459T1 (de) 1999-01-19 2010-05-15 Maxygen Inc Durch oligonukleotide-vermittelte nukleinsäuren- rekombination
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US8457903B1 (en) 1999-01-19 2013-06-04 Codexis Mayflower Holdings, Llc Method and/or apparatus for determining codons
US7702464B1 (en) 2001-08-21 2010-04-20 Maxygen, Inc. Method and apparatus for codon determining
US20070065838A1 (en) 1999-01-19 2007-03-22 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
CA2361384A1 (en) 1999-02-11 2000-08-17 Sun Ai Raillard High throughput mass spectrometry
AU3391900A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Encryption of traits using split gene sequences
US6703240B1 (en) 1999-04-13 2004-03-09 Maxygar, Inc. Modified starch metabolism enzymes and encoding genes for improvement and optimization of plant phenotypes
IL148786A0 (en) * 1999-09-21 2002-09-12 Basf Ag Methods and microorganisms for production of panto-compounds
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6519065B1 (en) 1999-11-05 2003-02-11 Jds Fitel Inc. Chromatic dispersion compensation device
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
SG121902A1 (en) 2000-01-11 2006-05-26 Maxygen Inc Integrated systems for diversity generation and screening
WO2001075767A2 (en) 2000-03-30 2001-10-11 Maxygen, Inc. In silico cross-over site selection
AU4981101A (en) 2000-04-03 2001-10-15 Maxygen Inc Subtilisin variants
US7783428B2 (en) 2002-03-01 2010-08-24 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US20050084907A1 (en) 2002-03-01 2005-04-21 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
US7747391B2 (en) 2002-03-01 2010-06-29 Maxygen, Inc. Methods, systems, and software for identifying functional biomolecules
AU2003213846A1 (en) 2002-03-09 2003-09-29 Maxygen, Inc. Optimization of crossover points for directed evolution
US8768871B2 (en) 2008-02-12 2014-07-01 Codexis, Inc. Method of generating an optimized, diverse population of variants
US8504498B2 (en) 2008-02-12 2013-08-06 Codexis, Inc. Method of generating an optimized, diverse population of variants
ES2575005T3 (es) 2008-06-13 2016-06-23 Codexis, Inc. Método de síntesis de variantes de polinucleótidos
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
US8383346B2 (en) 2008-06-13 2013-02-26 Codexis, Inc. Combined automated parallel synthesis of polynucleotide variants
US8609396B2 (en) * 2009-08-28 2013-12-17 Cj Cheiljedang Corporation Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism
PL2657250T3 (pl) 2010-12-21 2018-02-28 Cj Cheiljedang Corporation Odmiana polipeptydu posiadającego aktywność acetylotransferazy homoseryny oraz mikroorganizm wyrażający to samo
EP2726651B1 (en) 2011-06-28 2018-11-07 Codexis, Inc. Protein variant generation by region shuffling
WO2013159055A1 (en) 2012-04-20 2013-10-24 Codexis, Inc. Production of fatty alcohols from engineered microorganisms
SG11202012136YA (en) * 2018-07-09 2021-01-28 Codexis Inc Engineered pantothenate kinase variant enzymes

Also Published As

Publication number Publication date
US20200010815A1 (en) 2020-01-09
JP2021530216A (ja) 2021-11-11
EP3820991A1 (en) 2021-05-19
CA3103819A1 (en) 2020-01-16
WO2020014050A1 (en) 2020-01-16
AU2019300838A1 (en) 2021-01-07
US20210102179A1 (en) 2021-04-08
SG11202012136YA (en) 2021-01-28
CN112673091A (zh) 2021-04-16
US10889806B2 (en) 2021-01-12
KR20210031929A (ko) 2021-03-23
EP3820991A4 (en) 2022-07-06
IL279884A (en) 2021-03-01

Similar Documents

Publication Publication Date Title
MX2021000322A (es) Enzimas de variante fosfopentomutasa modificada geneticamente.
MX2021000323A (es) Enzimas de variante de pantotenato quinasa modificadas geneticamente.
MX2021000327A (es) Enzimas de variante de fosforilasa de nucleosido de purina modificadas geneticamente.
MX2018013139A (es) Composiciones detergentes y sus usos.
MX2021000328A (es) Enzimas de variantes de galactosa oxidasa modificadas geneticamente.
AU2017380488A8 (en) Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof
PH12018502035A1 (en) Protease-activated t cell bispecific molecules
MX2021013476A (es) Composiciones de pienso para animales y uso de las mismas.
PH12014502767A1 (en) Interleukin-2 fusion proteins and uses thereof
EP3708660A3 (en) Polypeptides
WO2018191502A3 (en) Anti-cd137 antibodies and methods of use thereof
EP3741849A3 (en) Protease variants and polynucleotides encoding same
MX2017014125A (es) Variantes de alfa-amilasa y polinucleotidos que codifican las mismas.
MX2019000140A (es) Variantes de xilanasa y polinucleotidos que las codifican.
WO2016066756A3 (en) Protease variants and polynucleotides encoding same
WO2016066757A3 (en) Protease variants and polynucleotides encoding same
EP4273238A3 (en) Compositions comprising polypeptides having xylanase activity and polypeptides having arabinofuranosidase activity
EP3957723A3 (en) Engineered ligase variants
MX2018007485A (es) Variantes de enzimas y polinucleotidos que las codifican.
MX2021015614A (es) Enzimas variantes de sacarosa fosforilasa modificadas geneticamente.
PH12018502656A1 (en) Engineered beta-glucosidases and glycosylation methods
EP3929285A3 (en) Methods of reducing odor
AU2018264463A1 (en) Polypeptides having lysozyme activity, polynucleotides encoding same and uses and compositions thereof
MX349517B (es) Polipeptidos que tienen actividad de proteasa y polinucleotidos que codifican los mismos.
MY183061A (en) Polypeptides having xylanase activity with a high conversion rate of xylose-containing polysaccharides