MX2021015613A - Enzimas variantes acetato cinasa dise?adas. - Google Patents

Enzimas variantes acetato cinasa dise?adas.

Info

Publication number
MX2021015613A
MX2021015613A MX2021015613A MX2021015613A MX2021015613A MX 2021015613 A MX2021015613 A MX 2021015613A MX 2021015613 A MX2021015613 A MX 2021015613A MX 2021015613 A MX2021015613 A MX 2021015613A MX 2021015613 A MX2021015613 A MX 2021015613A
Authority
MX
Mexico
Prior art keywords
enzymes
engineered
ack
acetate kinase
present
Prior art date
Application number
MX2021015613A
Other languages
English (en)
Inventor
Jonathan Vroom
Jovana Nazor
Mikayla Jianghongxia Krawczyk
Guerra Alberto Ortega
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of MX2021015613A publication Critical patent/MX2021015613A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02001—Acetate kinase (2.7.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención provee enzimas acetato cinasa (AcK) diseñadas, polipéptidos que tienen actividad de AcK, y polinucleótidos que codifican para estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; se proveen también métodos para producir enzimas AcK; la presente invención provee además composiciones que comprenden las enzimas AcK, y métodos de uso de las enzimas AcK diseñadas; la presente invención encuentra uso particular en la producción de compuestos farmacéuticos.
MX2021015613A 2019-07-02 2020-06-30 Enzimas variantes acetato cinasa dise?adas. MX2021015613A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962869667P 2019-07-02 2019-07-02
PCT/US2020/040244 WO2021003129A2 (en) 2019-07-02 2020-06-30 Engineered acetate kinase variant enzymes

Publications (1)

Publication Number Publication Date
MX2021015613A true MX2021015613A (es) 2022-02-03

Family

ID=74101253

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021015613A MX2021015613A (es) 2019-07-02 2020-06-30 Enzimas variantes acetato cinasa dise?adas.

Country Status (12)

Country Link
US (1) US20220251523A1 (es)
EP (1) EP3994153A4 (es)
JP (1) JP2022538229A (es)
KR (1) KR20220025884A (es)
CN (1) CN114127102A (es)
AU (1) AU2020299358A1 (es)
BR (1) BR112021024819A2 (es)
CA (1) CA3142162A1 (es)
IL (1) IL289508A (es)
MX (1) MX2021015613A (es)
SG (1) SG11202113108UA (es)
WO (1) WO2021003129A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117222735A (zh) * 2021-04-02 2023-12-12 科德克希思公司 工程化乙酸激酶变体酶
CN115975976A (zh) * 2022-12-27 2023-04-18 山东福洋生物科技股份有限公司 一种同时生产高活性烟酰胺核糖激酶和乙酰磷酸激酶的方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201115911D0 (en) * 2011-09-14 2011-10-26 Health Prot Agency Thermostable assay reagents
KR101735935B1 (ko) * 2015-07-20 2017-05-16 씨제이제일제당 (주) 퓨트레신 또는 오르니틴 생산 미생물 및 이를 이용한 퓨트레신 또는 오르니틴 생산방법
MX2021000323A (es) * 2018-07-09 2021-03-25 Codexis Inc Enzimas de variante de pantotenato quinasa modificadas geneticamente.
CN112996511B (zh) * 2018-07-09 2024-08-09 默沙东有限责任公司 4’-乙炔基核苷类似物的酶促合成

Also Published As

Publication number Publication date
IL289508A (en) 2022-03-01
WO2021003129A3 (en) 2021-02-25
US20220251523A1 (en) 2022-08-11
AU2020299358A1 (en) 2021-12-23
SG11202113108UA (en) 2021-12-30
CN114127102A (zh) 2022-03-01
CA3142162A1 (en) 2021-01-07
KR20220025884A (ko) 2022-03-03
WO2021003129A2 (en) 2021-01-07
EP3994153A4 (en) 2023-10-11
BR112021024819A2 (pt) 2022-01-25
EP3994153A2 (en) 2022-05-11
JP2022538229A (ja) 2022-09-01

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