DE602006015306D1 - Modifizierte mitglieder der leukocyten-ig-ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung - Google Patents

Modifizierte mitglieder der leukocyten-ig-ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung

Info

Publication number
DE602006015306D1
DE602006015306D1 DE602006015306T DE602006015306T DE602006015306D1 DE 602006015306 D1 DE602006015306 D1 DE 602006015306D1 DE 602006015306 T DE602006015306 T DE 602006015306T DE 602006015306 T DE602006015306 T DE 602006015306T DE 602006015306 D1 DE602006015306 D1 DE 602006015306D1
Authority
DE
Germany
Prior art keywords
class
pmhc
lir
mhc
leukocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006015306T
Other languages
English (en)
Inventor
Bent Karsten Jakobsen
Yi Li
Ruth Karen Moysey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medigene Ltd
Original Assignee
Medigene Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Ltd filed Critical Medigene Ltd
Publication of DE602006015306D1 publication Critical patent/DE602006015306D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DE602006015306T 2005-05-25 2006-05-19 Modifizierte mitglieder der leukocyten-ig-ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung Active DE602006015306D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0510627.3A GB0510627D0 (en) 2005-05-25 2005-05-25 Polypeptides
PCT/GB2006/001860 WO2006125963A2 (en) 2005-05-25 2006-05-19 Modified leukocyte ig-like receptor family members (lir' s) with increased affinity for class i mhc and their uses in modulating t cell activation

Publications (1)

Publication Number Publication Date
DE602006015306D1 true DE602006015306D1 (de) 2010-08-19

Family

ID=34834594

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006015306T Active DE602006015306D1 (de) 2005-05-25 2006-05-19 Modifizierte mitglieder der leukocyten-ig-ähnlichen-rezeptorfamilie (lir's) mit erhöhter affinität für klasse-i-mhc und deren anwendungen bei der modulierung der t-zellen-aktivierung

Country Status (15)

Country Link
US (1) US8092807B2 (de)
EP (1) EP1885752B1 (de)
JP (1) JP2008545404A (de)
CN (1) CN101268100A (de)
AT (1) ATE473240T1 (de)
AU (1) AU2006250976A1 (de)
BR (1) BRPI0611167A2 (de)
CA (1) CA2609447A1 (de)
DE (1) DE602006015306D1 (de)
EA (1) EA200702609A1 (de)
ES (1) ES2348674T3 (de)
GB (1) GB0510627D0 (de)
MX (1) MX2007014585A (de)
WO (1) WO2006125963A2 (de)
ZA (1) ZA200709924B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623539D0 (en) * 2006-11-24 2007-01-03 Avidex Ltd Polypeptides
WO2008062147A1 (en) 2006-11-24 2008-05-29 Medigene Limited ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES
WO2009060159A1 (en) * 2007-11-08 2009-05-14 Medigene Limited Mutated ilt molecules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2338283T3 (es) 1996-12-06 2010-05-05 Schering Corporation Genes encontrados de celulas monociticas de mamiferos; reactivos relacionados.
US6384203B1 (en) * 1999-05-12 2002-05-07 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
US6448035B1 (en) * 1997-04-24 2002-09-10 Immunex Corporation Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR)
GB9722779D0 (en) 1997-10-28 1997-12-24 Isis Innovation Human CD8 as an inhibitor of the cellular immune system
EP1066380B1 (de) 1998-05-19 2001-11-14 Avidex Ltd Löslicher t-zell rezeptor
JP2004524001A (ja) 2000-01-25 2004-08-12 ハイセック，インコーポレーテッド 白血球免疫グロブリン受容体（ｌｉｒ様）ポリペプチドおよびポリヌクレオチドに関する方法と材料
EP1453540A4 (de) 2001-11-14 2005-06-01 Immunex Corp Modulation der lir-funktion zur behandlung der rheumatoiden arthritis
JP2006515747A (ja) 2002-11-01 2006-06-08 ジェネンテック・インコーポレーテッド 免疫関連疾患の治療のための組成物と方法
WO2005058953A2 (en) 2003-12-12 2005-06-30 Regeneron Pharmaceuticals, Inc. Ogh fusion polypeptides and therapeutic uses thereof
JP2008504012A (ja) 2004-01-28 2008-02-14 シントニックス・ファーマシューティカルズ・インコーポレーテッド 不妊治療のためのへテロ二量体卵胞刺激ホルモン−Ｆｃ（ＦＳＨ−Ｆｃ）融合タンパク質
GB0411773D0 (en) 2004-05-26 2004-06-30 Avidex Ltd Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex
US8207110B2 (en) 2004-09-03 2012-06-26 The Trustees Of Columbia University In The City Of New York ITL3 polypeptides and uses thereof
WO2008062147A1 (en) 2006-11-24 2008-05-29 Medigene Limited ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES

Also Published As

Publication number Publication date
MX2007014585A (es) 2008-04-22
US20090208447A1 (en) 2009-08-20
ATE473240T1 (de) 2010-07-15
EP1885752A2 (de) 2008-02-13
EA200702609A1 (ru) 2008-10-30
CA2609447A1 (en) 2006-11-30
ZA200709924B (en) 2009-03-25
AU2006250976A1 (en) 2006-11-30
GB0510627D0 (en) 2005-06-29
ES2348674T3 (es) 2010-12-10
WO2006125963A2 (en) 2006-11-30
JP2008545404A (ja) 2008-12-18
CN101268100A (zh) 2008-09-17
BRPI0611167A2 (pt) 2010-08-17
WO2006125963A3 (en) 2008-04-17
EP1885752B1 (de) 2010-07-07
US8092807B2 (en) 2012-01-10

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