MX2007014585A - Polipeptidos. - Google Patents
Polipeptidos.Info
- Publication number
- MX2007014585A MX2007014585A MX2007014585A MX2007014585A MX2007014585A MX 2007014585 A MX2007014585 A MX 2007014585A MX 2007014585 A MX2007014585 A MX 2007014585A MX 2007014585 A MX2007014585 A MX 2007014585A MX 2007014585 A MX2007014585 A MX 2007014585A
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- pmhc
- polypeptide
- polypeptides
- given class
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invencion proporciona polipeptidos que tienen la propiedad de unirse a una pMHC Clase I dada, caracterizada ademas porque el polipeptido tiene una KD para la pMHC Clase I dada de menos que o igual a 1 (M y/o tiene una velocidad apagada (koff) para la molecula pMHC Clase I dada de 2 S-1 o mas lenta, y el polipeptido tiene al menos una identidad de 45% y/o similitud de 55% con SEQ ID NO: 7, y el polipeptido inhibe la union de CD8 a la pMHC dada a un mayor grado que el polipeptido de SEQ ID NO: 3. Estos polipeptidos son utiles, ya sea solos o asociados con un agente terapeutico, para la inhibicion de respuestas de celulas T citotoxicas (CTL).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0510627.3A GB0510627D0 (en) | 2005-05-25 | 2005-05-25 | Polypeptides |
| PCT/GB2006/001860 WO2006125963A2 (en) | 2005-05-25 | 2006-05-19 | Modified leukocyte ig-like receptor family members (lir' s) with increased affinity for class i mhc and their uses in modulating t cell activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007014585A true MX2007014585A (es) | 2008-04-22 |
Family
ID=34834594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007014585A MX2007014585A (es) | 2005-05-25 | 2006-05-19 | Polipeptidos. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8092807B2 (es) |
| EP (1) | EP1885752B1 (es) |
| JP (1) | JP2008545404A (es) |
| CN (1) | CN101268100A (es) |
| AT (1) | ATE473240T1 (es) |
| AU (1) | AU2006250976A1 (es) |
| BR (1) | BRPI0611167A2 (es) |
| CA (1) | CA2609447A1 (es) |
| DE (1) | DE602006015306D1 (es) |
| EA (1) | EA200702609A1 (es) |
| ES (1) | ES2348674T3 (es) |
| GB (1) | GB0510627D0 (es) |
| MX (1) | MX2007014585A (es) |
| WO (1) | WO2006125963A2 (es) |
| ZA (1) | ZA200709924B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2084184A1 (en) | 2006-11-24 | 2009-08-05 | Medigene Limited | ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES |
| GB0623539D0 (en) * | 2006-11-24 | 2007-01-03 | Avidex Ltd | Polypeptides |
| WO2009060159A1 (en) * | 2007-11-08 | 2009-05-14 | Medigene Limited | Mutated ilt molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0948623B1 (en) | 1996-12-06 | 2010-01-27 | Schering Corporation | Isolated mammalian monocyte cell genes; related reagents |
| US6448035B1 (en) * | 1997-04-24 | 2002-09-10 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptor (LIR) |
| US6384203B1 (en) * | 1999-05-12 | 2002-05-07 | Immunex Corporation | Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR) |
| GB9722779D0 (en) | 1997-10-28 | 1997-12-24 | Isis Innovation | Human CD8 as an inhibitor of the cellular immune system |
| IL139344A0 (en) | 1998-05-19 | 2001-11-25 | Avidex Ltd | Soluble t cell receptor |
| JP2004524001A (ja) | 2000-01-25 | 2004-08-12 | ハイセック，インコーポレーテッド | 白血球免疫グロブリン受容体（ｌｉｒ様）ポリペプチドおよびポリヌクレオチドに関する方法と材料 |
| MXPA04004491A (es) | 2001-11-14 | 2005-05-16 | Immunex Corp | Modulacion de funcion de receptores similares a inmunoglobulina leucocitaria para tratar artritis reumatoide. |
| US20060263774A1 (en) | 2002-11-01 | 2006-11-23 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| WO2005058953A2 (en) | 2003-12-12 | 2005-06-30 | Regeneron Pharmaceuticals, Inc. | Ogh fusion polypeptides and therapeutic uses thereof |
| US7601516B2 (en) | 2004-01-28 | 2009-10-13 | Syntomix Pharmaceuticals, Inc. | Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility |
| GB0411773D0 (en) | 2004-05-26 | 2004-06-30 | Avidex Ltd | Method for the identification of polypeptides which bind to a given peptide mhc complex or cd 1-antigen complex |
| US8207110B2 (en) | 2004-09-03 | 2012-06-26 | The Trustees Of Columbia University In The City Of New York | ITL3 polypeptides and uses thereof |
| EP2084184A1 (en) | 2006-11-24 | 2009-08-05 | Medigene Limited | ILT-2 (LIRl ) VARIANTS WITH INCREASED AFFINITY FOR MHC CLASS I MOLECULES |
-
2005
- 2005-05-25 GB GBGB0510627.3A patent/GB0510627D0/en not_active Ceased
-
2006
- 2006-05-19 BR BRPI0611167-0A patent/BRPI0611167A2/pt not_active IP Right Cessation
- 2006-05-19 CA CA002609447A patent/CA2609447A1/en not_active Abandoned
- 2006-05-19 WO PCT/GB2006/001860 patent/WO2006125963A2/en active Application Filing
- 2006-05-19 EA EA200702609A patent/EA200702609A1/ru unknown
- 2006-05-19 DE DE602006015306T patent/DE602006015306D1/de active Active
- 2006-05-19 EP EP06727147A patent/EP1885752B1/en not_active Not-in-force
- 2006-05-19 AU AU2006250976A patent/AU2006250976A1/en not_active Abandoned
- 2006-05-19 JP JP2008512902A patent/JP2008545404A/ja active Pending
- 2006-05-19 US US11/914,175 patent/US8092807B2/en not_active Expired - Fee Related
- 2006-05-19 CN CNA2006800180690A patent/CN101268100A/zh active Pending
- 2006-05-19 MX MX2007014585A patent/MX2007014585A/es not_active Application Discontinuation
- 2006-05-19 ES ES06727147T patent/ES2348674T3/es active Active
- 2006-05-19 AT AT06727147T patent/ATE473240T1/de not_active IP Right Cessation
-
2007
- 2007-11-16 ZA ZA200709924A patent/ZA200709924B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008545404A (ja) | 2008-12-18 |
| CN101268100A (zh) | 2008-09-17 |
| DE602006015306D1 (de) | 2010-08-19 |
| AU2006250976A1 (en) | 2006-11-30 |
| CA2609447A1 (en) | 2006-11-30 |
| ATE473240T1 (de) | 2010-07-15 |
| WO2006125963A3 (en) | 2008-04-17 |
| EA200702609A1 (ru) | 2008-10-30 |
| EP1885752A2 (en) | 2008-02-13 |
| US8092807B2 (en) | 2012-01-10 |
| US20090208447A1 (en) | 2009-08-20 |
| EP1885752B1 (en) | 2010-07-07 |
| WO2006125963A2 (en) | 2006-11-30 |
| ES2348674T3 (es) | 2010-12-10 |
| ZA200709924B (en) | 2009-03-25 |
| GB0510627D0 (en) | 2005-06-29 |
| BRPI0611167A2 (pt) | 2010-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |