EA200701901A1 - Нуклеиновые кислоты, связывающие грелин - Google Patents

Нуклеиновые кислоты, связывающие грелин

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Publication number
EA200701901A1
EA200701901A1 EA200701901A EA200701901A EA200701901A1 EA 200701901 A1 EA200701901 A1 EA 200701901A1 EA 200701901 A EA200701901 A EA 200701901A EA 200701901 A EA200701901 A EA 200701901A EA 200701901 A1 EA200701901 A1 EA 200701901A1
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EA
Eurasian Patent Office
Prior art keywords
fragment
box
greeline
nucleic acids
acids binding
Prior art date
Application number
EA200701901A
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English (en)
Inventor
Флориан ЯРОШ
Дирк ОЙЛБЕРГ
Кристиан Маш
Штеффен Хельмлинг
Свен КЛУССМАНН
Original Assignee
Нокссон Фарма Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нокссон Фарма Аг filed Critical Нокссон Фарма Аг
Publication of EA200701901A1 publication Critical patent/EA200701901A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
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  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
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  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
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  • Hematology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

Настоящее изобретение относится к нуклеиновой кислоте, предпочтительно связывающейся с грелином, где нуклеиновая кислота включает первый фрагмент Бокс А и второй фрагмент Бокс В, где первый фрагмент Бокс А содержит приблизительно 25 последовательных нуклеотидов, второй фрагмент Бокс В содержит приблизительно шесть-восемь последовательных нуклеотидов, где 3'-концевой фрагмент нуклеотидов первого фрагмента Бокс А гибридизуется со вторым фрагментом Бокс В, причем при гибридизации образуется первая двухнитевая структура, где такая первая двухнитевая структура содержит петлю.
EA200701901A 2005-04-08 2006-04-10 Нуклеиновые кислоты, связывающие грелин EA200701901A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05007795 2005-04-08
PCT/EP2006/003276 WO2006108599A2 (en) 2005-04-08 2006-04-10 Ghrelin binding nucleic acids

Publications (1)

Publication Number Publication Date
EA200701901A1 true EA200701901A1 (ru) 2008-04-28

Family

ID=37087373

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701901A EA200701901A1 (ru) 2005-04-08 2006-04-10 Нуклеиновые кислоты, связывающие грелин

Country Status (24)

Country Link
US (2) US8101734B2 (ru)
EP (1) EP1866412A2 (ru)
JP (2) JP5308813B2 (ru)
KR (1) KR20080009072A (ru)
CN (1) CN101189337B (ru)
AP (1) AP2007004189A0 (ru)
AR (1) AR052741A1 (ru)
AU (1) AU2006233647A1 (ru)
BR (1) BRPI0608180A2 (ru)
CA (1) CA2605377A1 (ru)
CR (1) CR9423A (ru)
DO (1) DOP2006000085A (ru)
EA (1) EA200701901A1 (ru)
GB (1) GB2439673A (ru)
GT (1) GT200600137A (ru)
IL (1) IL186085A0 (ru)
MA (1) MA29384B1 (ru)
MX (1) MX2007012419A (ru)
NL (2) NL1031538C2 (ru)
PE (1) PE20061358A1 (ru)
TN (1) TNSN07375A1 (ru)
TW (1) TW200718781A (ru)
UY (1) UY29460A1 (ru)
WO (1) WO2006108599A2 (ru)

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Also Published As

Publication number Publication date
TNSN07375A1 (fr) 2009-03-17
AP2007004189A0 (en) 2007-10-31
NL1033520C2 (nl) 2010-01-21
US8101734B2 (en) 2012-01-24
US20120115937A1 (en) 2012-05-10
JP5308813B2 (ja) 2013-10-09
GB2439673A (en) 2008-01-02
PE20061358A1 (es) 2007-01-13
NL1031538C2 (nl) 2007-03-20
CN101189337A (zh) 2008-05-28
CA2605377A1 (en) 2006-10-19
KR20080009072A (ko) 2008-01-24
US20060258607A1 (en) 2006-11-16
GB0719489D0 (en) 2007-11-21
WO2006108599A2 (en) 2006-10-19
CR9423A (es) 2007-12-17
NL1031538A1 (nl) 2006-10-10
GT200600137A (es) 2006-11-22
IL186085A0 (en) 2008-01-20
MX2007012419A (es) 2007-12-05
AU2006233647A2 (en) 2008-04-17
AR052741A1 (es) 2007-03-28
MA29384B1 (fr) 2008-04-01
TW200718781A (en) 2007-05-16
JP2013176372A (ja) 2013-09-09
JP2008534024A (ja) 2008-08-28
EP1866412A2 (en) 2007-12-19
CN101189337B (zh) 2013-11-06
DOP2006000085A (es) 2006-11-15
UY29460A1 (es) 2006-11-30
AU2006233647A1 (en) 2006-10-19
BRPI0608180A2 (pt) 2009-11-17
NL1033520A1 (nl) 2007-08-06
WO2006108599A3 (en) 2007-02-15

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