ATE540127T1 - Multiplex pcr - Google Patents
Multiplex pcrInfo
- Publication number
- ATE540127T1 ATE540127T1 AT02803689T AT02803689T ATE540127T1 AT E540127 T1 ATE540127 T1 AT E540127T1 AT 02803689 T AT02803689 T AT 02803689T AT 02803689 T AT02803689 T AT 02803689T AT E540127 T1 ATE540127 T1 AT E540127T1
- Authority
- AT
- Austria
- Prior art keywords
- templates
- multiplex pcr
- appending
- distinct sequence
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33169301P | 2001-11-19 | 2001-11-19 | |
PCT/US2002/037238 WO2003044177A2 (en) | 2001-11-19 | 2002-11-19 | Multiplex pcr |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540127T1 true ATE540127T1 (de) | 2012-01-15 |
Family
ID=23294970
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02803689T ATE540127T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex pcr |
AT02803690T ATE425263T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex-oligonukleotidaddition und zielamplifikation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02803690T ATE425263T1 (de) | 2001-11-19 | 2002-11-19 | Multiplex-oligonukleotidaddition und zielamplifikation |
Country Status (9)
Country | Link |
---|---|
US (3) | US7510829B2 (de) |
EP (2) | EP1456416B1 (de) |
JP (2) | JP2005509433A (de) |
CN (2) | CN100396788C (de) |
AT (2) | ATE540127T1 (de) |
AU (2) | AU2002366098A1 (de) |
CA (2) | CA2467577A1 (de) |
DE (1) | DE60231543D1 (de) |
WO (2) | WO2003044177A2 (de) |
Families Citing this family (67)
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DE60231543D1 (de) * | 2001-11-19 | 2009-04-23 | Parallele Bioscience Inc | Multiplex-oligonukleotidaddition und zielamplifikation |
US20110151438A9 (en) * | 2001-11-19 | 2011-06-23 | Affymetrix, Inc. | Methods of Analysis of Methylation |
JP2006500959A (ja) * | 2002-09-30 | 2006-01-12 | パラレル バイオサイエンス, インコーポレイテッド | 動的サンプリング結合によるポリヌクレオチド合成および標識化 |
US20060141498A1 (en) * | 2003-09-25 | 2006-06-29 | Affymetrix, Inc. | Methods for fragmenting nucleic acid |
NZ546903A (en) * | 2003-10-13 | 2009-06-26 | Genaco Biomedical Products Inc | Method and kit for primer based amplification of nucleic acids |
US8029454B2 (en) | 2003-11-05 | 2011-10-04 | Baxter International Inc. | High convection home hemodialysis/hemofiltration and sorbent system |
US7531306B2 (en) | 2003-11-12 | 2009-05-12 | Geneohm Sciences, Inc. | Nucleic acid hybridization methods |
US20060029954A1 (en) * | 2004-06-30 | 2006-02-09 | Applera Corporation | Compositions and methods for identifying nucleotides in polynucleotide sequences |
DK2620510T4 (da) | 2005-06-15 | 2020-03-30 | Complete Genomics Inc | Enkeltmolekyle-arrays til genetisk og kemisk analyse |
US8137936B2 (en) * | 2005-11-29 | 2012-03-20 | Macevicz Stephen C | Selected amplification of polynucleotides |
WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
EP2589668A1 (de) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten |
CN100427607C (zh) * | 2006-09-19 | 2008-10-22 | 南京师范大学 | 一种克隆新基因的试剂盒及其应用方法 |
US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
US7862999B2 (en) | 2007-01-17 | 2011-01-04 | Affymetrix, Inc. | Multiplex targeted amplification using flap nuclease |
US20080293589A1 (en) * | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
EP2195452B1 (de) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion |
US9388457B2 (en) * | 2007-09-14 | 2016-07-12 | Affymetrix, Inc. | Locus specific amplification using array probes |
US8716190B2 (en) | 2007-09-14 | 2014-05-06 | Affymetrix, Inc. | Amplification and analysis of selected targets on solid supports |
US8114276B2 (en) | 2007-10-24 | 2012-02-14 | Baxter International Inc. | Personal hemodialysis system |
US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
US20090233809A1 (en) * | 2008-03-04 | 2009-09-17 | Affymetrix, Inc. | Resequencing methods for identification of sequence variants |
US9068209B2 (en) | 2008-05-14 | 2015-06-30 | British Columbia Cancer Agency Branch | Gene synthesis by convergent assembly of oligonucleotide subsets |
US20100279295A1 (en) * | 2009-03-18 | 2010-11-04 | Sequenom, Inc. | Use of thermostable endonucleases for generating reporter molecules |
JP2012525147A (ja) | 2009-04-30 | 2012-10-22 | グッド スタート ジェネティクス, インコーポレイテッド | 遺伝マーカーを評価するための方法および組成物 |
US20110111462A1 (en) * | 2009-11-06 | 2011-05-12 | Stephen Picone | Composition and Method for Synthesizing a Deoxyribonucleotide Chain Using a Double Stranded Nucleic Acid Complex with a Thermostable Polymerase |
JP2013511991A (ja) * | 2009-11-25 | 2013-04-11 | クアンタライフ, インコーポレイテッド | 遺伝子材料を検出する方法および組成物 |
CN102399864A (zh) * | 2010-09-16 | 2012-04-04 | 上海迦美生物科技有限公司 | 基于引物保护解除的甲基化dna的检测方法 |
CN101956023B (zh) * | 2010-09-16 | 2012-10-31 | 西南大学 | 检测十种主要柑桔病害病原的基因芯片 |
US9163281B2 (en) | 2010-12-23 | 2015-10-20 | Good Start Genetics, Inc. | Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction |
EP2673380B1 (de) | 2011-02-09 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Analyse von nukleinsäuren |
US8759036B2 (en) | 2011-03-21 | 2014-06-24 | Affymetrix, Inc. | Methods for synthesizing pools of probes |
GB2492042B (en) * | 2011-05-11 | 2020-04-15 | Agilent Technologies Inc | Selector probes for nucleic acid analysis comprising at each end a non-adjacent target specific region |
EP2768983A4 (de) | 2011-10-17 | 2015-06-03 | Good Start Genetics Inc | Analyseverfahren |
EP3434789A1 (de) | 2012-01-13 | 2019-01-30 | Data2Bio | Genotypisierung durch eine sequenzierung der nächsten generation |
US8209130B1 (en) | 2012-04-04 | 2012-06-26 | Good Start Genetics, Inc. | Sequence assembly |
US8812422B2 (en) | 2012-04-09 | 2014-08-19 | Good Start Genetics, Inc. | Variant database |
US10227635B2 (en) | 2012-04-16 | 2019-03-12 | Molecular Loop Biosolutions, Llc | Capture reactions |
US9139870B2 (en) * | 2012-08-30 | 2015-09-22 | Gen-Probe Incorporated | Multiphase nucleic acid amplification |
WO2014152421A1 (en) | 2013-03-14 | 2014-09-25 | Good Start Genetics, Inc. | Methods for analyzing nucleic acids |
EP3005200A2 (de) | 2013-06-03 | 2016-04-13 | Good Start Genetics, Inc. | Verfahren und systeme zur speicherung von sequenzlesedaten |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
CN105555972B (zh) | 2013-07-25 | 2020-07-31 | 伯乐生命医学产品有限公司 | 遗传测定 |
US11041203B2 (en) | 2013-10-18 | 2021-06-22 | Molecular Loop Biosolutions, Inc. | Methods for assessing a genomic region of a subject |
US10851414B2 (en) | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
GB2520763A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Nucleic acid probe and method of detecting genomic fragments |
GB2520765A (en) | 2013-12-02 | 2015-06-03 | Vanadis Diagnostics Ab | Multiplex detection of nucleic acids |
WO2015175530A1 (en) | 2014-05-12 | 2015-11-19 | Gore Athurva | Methods for detecting aneuploidy |
EP2983297A1 (de) * | 2014-08-08 | 2016-02-10 | Thomson Licensing | Codeerzeugungsverfahren, Codeerzeugungsvorrichtung und computerlesbares Speichermedium |
US10174383B2 (en) | 2014-08-13 | 2019-01-08 | Vanadis Diagnostics | Method of estimating the amount of a methylated locus in a sample |
EP3180445A1 (de) * | 2014-08-14 | 2017-06-21 | Life Technologies Corporation | Multiplex-transkriptomanalyse |
WO2016040446A1 (en) | 2014-09-10 | 2016-03-17 | Good Start Genetics, Inc. | Methods for selectively suppressing non-target sequences |
WO2016048829A1 (en) | 2014-09-24 | 2016-03-31 | Good Start Genetics, Inc. | Process control for increased robustness of genetic assays |
US9441268B2 (en) * | 2014-11-26 | 2016-09-13 | Roche Molecular Systems, Inc. | Detecting single nucleotide polymorphism using overlapping hydrolysis probes |
EP3271480B8 (de) | 2015-01-06 | 2022-09-28 | Molecular Loop Biosciences, Inc. | Abtastung auf strukturelle varianten |
CN114196732A (zh) * | 2015-03-19 | 2022-03-18 | 康代思锐公司 | 用于核酸检测的被编码的双链探针及其用途 |
PL3350342T3 (pl) | 2015-09-18 | 2020-08-24 | Vanadis Diagnostics | Zestaw sond do analizowania próbki DNA i sposób jego zastosowania |
CA3041645C (en) | 2016-10-24 | 2021-11-02 | Geneinfosec, Inc. | Concealing information present within nucleic acids |
CA3056650A1 (en) | 2017-03-30 | 2018-10-04 | Pioneer Hi-Bred International, Inc. | Methods of identifying and characterizing gene editing variations in nucleic acids |
US11441174B2 (en) | 2017-06-02 | 2022-09-13 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
US11603557B2 (en) | 2017-06-02 | 2023-03-14 | Affymetrix, Inc. | Array-based methods for analysing mixed samples using differently labelled allele-specific probes |
CN107385052B (zh) * | 2017-08-08 | 2020-10-30 | 中国林业科学研究院热带林业研究所 | 用于鉴定桉树无性系的str引物及其应用 |
CN111918965A (zh) * | 2018-04-28 | 2020-11-10 | 深圳华大生命科学研究院 | 一种胎儿游离核酸的富集方法及其应用 |
CN108660146B (zh) * | 2018-05-22 | 2019-03-19 | 南京诺唯赞生物科技有限公司 | 一种提高PCR片段兼容性与效率的Topo1连接方法 |
SG11202101934SA (en) | 2018-07-30 | 2021-03-30 | Readcoor Llc | Methods and systems for sample processing or analysis |
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US588731A (en) * | 1897-08-24 | Slate-sprinkler | ||
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ATE492652T1 (de) * | 2000-02-07 | 2011-01-15 | Illumina Inc | Nukleinsäuredetektionsverfahren mit universellem priming |
EP1313881A2 (de) | 2000-06-06 | 2003-05-28 | TM Bioscience Corporation | Fangsonden für nuklensäuren sowie verwendung derselben |
AU2002211520A1 (en) | 2000-10-04 | 2002-04-15 | The Board Of Trustees Of The Leland Stanford Junior University | Renaturation, reassociation, association and hybridization of nucleic acid molecules |
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IE20000887A1 (en) | 2000-11-03 | 2002-12-11 | Univ College Cork Nat Univ Ie | Method for the amplification and optional characterisation of nucleic acids |
JP4422963B2 (ja) | 2001-01-25 | 2010-03-03 | ルミネックス モレキュラー ダイアグノスティックス, インク. | 標識および標識補体として使用するための非クロス交雑しているポリヌクレオチドのファミリー、製品、ならびにその使用方法 |
CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
DE60231543D1 (de) | 2001-11-19 | 2009-04-23 | Parallele Bioscience Inc | Multiplex-oligonukleotidaddition und zielamplifikation |
-
2002
- 2002-11-19 DE DE60231543T patent/DE60231543D1/de not_active Expired - Fee Related
- 2002-11-19 AT AT02803689T patent/ATE540127T1/de active
- 2002-11-19 AT AT02803690T patent/ATE425263T1/de not_active IP Right Cessation
- 2002-11-19 JP JP2003545802A patent/JP2005509433A/ja active Pending
- 2002-11-19 EP EP02803690A patent/EP1456416B1/de not_active Expired - Lifetime
- 2002-11-19 CN CNB028265912A patent/CN100396788C/zh not_active Expired - Fee Related
- 2002-11-19 CA CA002467577A patent/CA2467577A1/en not_active Abandoned
- 2002-11-19 CA CA002467460A patent/CA2467460A1/en not_active Abandoned
- 2002-11-19 CN CNA028265955A patent/CN1697882A/zh active Pending
- 2002-11-19 JP JP2003545837A patent/JP2005509440A/ja active Pending
- 2002-11-19 AU AU2002366098A patent/AU2002366098A1/en not_active Abandoned
- 2002-11-19 WO PCT/US2002/037238 patent/WO2003044177A2/en active Application Filing
- 2002-11-19 WO PCT/US2002/037239 patent/WO2003044216A2/en active Application Filing
- 2002-11-19 US US10/300,285 patent/US7510829B2/en not_active Expired - Fee Related
- 2002-11-19 AU AU2002366099A patent/AU2002366099A1/en not_active Abandoned
- 2002-11-19 US US10/300,311 patent/US7208295B2/en not_active Expired - Lifetime
- 2002-11-19 EP EP02803689A patent/EP1453979B1/de not_active Expired - Lifetime
-
2007
- 2007-04-24 US US11/739,654 patent/US7754451B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1610758A (zh) | 2005-04-27 |
AU2002366099A1 (en) | 2003-06-10 |
US20090004701A1 (en) | 2009-01-01 |
EP1453979A4 (de) | 2005-12-28 |
JP2005509440A (ja) | 2005-04-14 |
US7510829B2 (en) | 2009-03-31 |
ATE425263T1 (de) | 2009-03-15 |
US20030096291A1 (en) | 2003-05-22 |
CN1697882A (zh) | 2005-11-16 |
EP1453979A2 (de) | 2004-09-08 |
DE60231543D1 (de) | 2009-04-23 |
JP2005509433A (ja) | 2005-04-14 |
EP1456416A4 (de) | 2006-01-11 |
EP1456416A2 (de) | 2004-09-15 |
CA2467460A1 (en) | 2003-05-30 |
CA2467577A1 (en) | 2003-05-30 |
EP1453979B1 (de) | 2012-01-04 |
WO2003044177A3 (en) | 2003-08-28 |
US20030104459A1 (en) | 2003-06-05 |
CN100396788C (zh) | 2008-06-25 |
WO2003044177A2 (en) | 2003-05-30 |
AU2002366098A1 (en) | 2003-06-10 |
US7754451B2 (en) | 2010-07-13 |
US7208295B2 (en) | 2007-04-24 |
WO2003044216A2 (en) | 2003-05-30 |
EP1456416B1 (de) | 2009-03-11 |
WO2003044216A3 (en) | 2003-08-14 |
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