EA200701732A1 - Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq - Google Patents

Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq

Info

Publication number
EA200701732A1
EA200701732A1 EA200701732A EA200701732A EA200701732A1 EA 200701732 A1 EA200701732 A1 EA 200701732A1 EA 200701732 A EA200701732 A EA 200701732A EA 200701732 A EA200701732 A EA 200701732A EA 200701732 A1 EA200701732 A1 EA 200701732A1
Authority
EA
Eurasian Patent Office
Prior art keywords
orfanin
noctseptina
antagonists
receptor
highly efficient
Prior art date
Application number
EA200701732A
Other languages
English (en)
Other versions
EA011325B1 (ru
Inventor
Ремо Гуеррини
Северо Сальвадори
Джироламо Кало
Доменико Реголи
Original Assignee
Менарини Интернешнл Оперейшнз Люксембург С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Менарини Интернешнл Оперейшнз Люксембург С.А. filed Critical Менарини Интернешнл Оперейшнз Люксембург С.А.
Publication of EA200701732A1 publication Critical patent/EA200701732A1/ru
Publication of EA011325B1 publication Critical patent/EA011325B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

Описаны пептидные аналоги ноцицептина/орфанина FQ, их композиции и их применение в лечении расстройств и дисфункций, относящихся к активации или блокированию рецепторов NOP.
EA200701732A 2005-02-15 2006-02-15 Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq EA011325B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000003A ITFE20050003A1 (it) 2005-02-15 2005-02-15 Agonisti pieni e parziali ed antagonisti del recettore per nocicettina/orfanina fq ad elevata potenza.
PCT/EP2006/050958 WO2006087340A2 (en) 2005-02-15 2006-02-15 Highly potent full and partial agonists and antagonists of the nociceptin/orphanin fq receptor

Publications (2)

Publication Number Publication Date
EA200701732A1 true EA200701732A1 (ru) 2008-02-28
EA011325B1 EA011325B1 (ru) 2009-02-27

Family

ID=36685750

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701732A EA011325B1 (ru) 2005-02-15 2006-02-15 Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq

Country Status (29)

Country Link
US (1) US8227414B2 (ru)
EP (1) EP1851241B1 (ru)
JP (1) JP5281292B2 (ru)
KR (1) KR101294895B1 (ru)
CN (2) CN101128482A (ru)
AU (1) AU2006215639B2 (ru)
BR (1) BRPI0606998B8 (ru)
CA (1) CA2598121C (ru)
CR (1) CR9379A (ru)
CU (1) CU23823A3 (ru)
CY (1) CY1116456T1 (ru)
DK (1) DK1851241T3 (ru)
EA (1) EA011325B1 (ru)
ES (1) ES2541308T3 (ru)
HR (1) HRP20150731T1 (ru)
HU (1) HUE025000T2 (ru)
IL (1) IL185235A (ru)
IT (1) ITFE20050003A1 (ru)
MA (1) MA29288B1 (ru)
MX (1) MX2007009523A (ru)
NI (1) NI200700205A (ru)
NO (1) NO341856B1 (ru)
PL (1) PL1851241T3 (ru)
PT (1) PT1851241E (ru)
RS (1) RS54095B1 (ru)
SI (1) SI1851241T1 (ru)
UA (1) UA91844C2 (ru)
WO (1) WO2006087340A2 (ru)
ZA (1) ZA200707714B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITNA20090026A1 (it) * 2009-05-14 2010-11-15 Agostino Bruno D Agonisti del recettore nop e loro usi terapeutici
CN112730849B (zh) * 2021-01-14 2023-03-10 山西医科大学第二医院 内源性孤啡肽作为糖尿病合并无症状性心肌缺血的血清生物标志物的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003237119A1 (en) * 2002-04-29 2003-11-17 Euro-Celtique S.A. Conformationally constrained peptides that bind the orl-1 receptor
ITMI20022022A1 (it) * 2002-09-24 2004-03-25 Girolamo Calo' Analoghi di nocicettina.
ITMI20031349A1 (it) * 2003-07-01 2005-01-02 Ufpeptides S R L Antagonisti del recettore nop e loro usi terapeutici.
CN1634980A (zh) * 2004-10-10 2005-07-06 兰州大学 孤啡肽的类似物

Also Published As

Publication number Publication date
CU23823A3 (es) 2012-06-21
PT1851241E (pt) 2015-08-28
DK1851241T3 (en) 2015-06-29
CR9379A (es) 2008-04-25
CY1116456T1 (el) 2017-03-15
WO2006087340A3 (en) 2006-10-26
IL185235A0 (en) 2008-02-09
BRPI0606998A2 (pt) 2014-01-21
NO341856B1 (no) 2018-02-12
BRPI0606998B8 (pt) 2021-05-25
SI1851241T1 (sl) 2015-08-31
CN101128482A (zh) 2008-02-20
WO2006087340A8 (en) 2007-06-21
KR101294895B1 (ko) 2013-08-08
WO2006087340A2 (en) 2006-08-24
IL185235A (en) 2014-08-31
ITFE20050003A1 (it) 2006-08-16
EA011325B1 (ru) 2009-02-27
NO20074702L (no) 2007-10-29
MX2007009523A (es) 2007-09-07
CA2598121C (en) 2014-11-25
NI200700205A (es) 2008-06-17
HUE025000T2 (en) 2016-01-28
KR20070119614A (ko) 2007-12-20
EP1851241B1 (en) 2015-04-08
CA2598121A1 (en) 2006-08-24
AU2006215639B2 (en) 2011-05-26
ES2541308T3 (es) 2015-07-17
US8227414B2 (en) 2012-07-24
JP5281292B2 (ja) 2013-09-04
PL1851241T3 (pl) 2015-09-30
UA91844C2 (ru) 2010-09-10
AU2006215639A1 (en) 2006-08-24
BRPI0606998B1 (pt) 2018-04-10
US20100273710A1 (en) 2010-10-28
JP2008530058A (ja) 2008-08-07
ZA200707714B (en) 2008-06-25
EP1851241A2 (en) 2007-11-07
CN104689293A (zh) 2015-06-10
MA29288B1 (fr) 2008-02-01
HRP20150731T1 (hr) 2015-08-14
RS54095B1 (en) 2015-10-30

Similar Documents

Publication Publication Date Title
CY1115004T1 (el) Φαρμακευτικοι συνδυασμοι ενος ανταγωνιστη υποδοχεων αγγειοτασινης και ενος αναστολεα νερ
CY1117124T1 (el) ΑΝΘΡΩΠΟΠΟΙΗΜΕΝΟΙ ANTΑΓΩΝΙΣΤΕΣ ΑΝΤΙ-β7 ΚΑΙ ΧΡΗΣΕΙΣ ΑΥΤΩΝ
SI1750704T1 (sl) Antagonisti seäśnine iz p2y1 receptorja uporabnega pri zdravljenju trombotiäśnih stanj
CY1110882T1 (el) Ανταγωνιστες υποδοχεων ορεξινης υποκατεστημενης διαζεπανης
ATE461932T1 (de) Pyrazoloä4,3-eü-1,2,4-triazoloä1,5-cüpyrimidine als antagonisten des adenosin-a2a-rezeptors
EA200602062A1 (ru) Амидосоединения и их применение в качестве фармацевтических средств
ATE556060T1 (de) Monocyclische anilidspirohydantoine als cgrp- rezeptorantagonisten
EA201300330A1 (ru) Антагонисты активина-actriia и их применение для стимулирования роста кости
EA201491697A1 (ru) Составы агонистов гуанилатциклазы с и способы применения
DE602007012072D1 (de) Orantagonisten
DK1725540T5 (da) Diaminopyrimidiner som p2x3- og p2x2/3-antagonister
CR8891A (es) Antagonismo de la actividad del receptor de interleuquina 21
CL2006003736A1 (es) Compuestos derivados de triazina o pirimidina sustituida, antagonistas del receptor de prokineticina 1, composicion farmaceutica; y uso en el tratamiento de trastornos gastrointestinales.
NO20082345L (no) Selektive VPAC2 reseptorpeptidagonister
DE602007004999D1 (de) 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen-derivate als orexinrezeptor-antagonisten
ATE389670T1 (de) Selektive peptidische agonisten des vpac2- rezeptors
MA33059B1 (fr) Utilisation d'antagonistes des recepteurs nk
BRPI0818450A2 (pt) Antagonistas do receptor de 5-ht7
ATE519498T1 (de) Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen
CY1109803T1 (el) Φαρμακευτικες συνθεσεις που βασιζονται σε ανταγωνιστες νκ2 για παιδιατρικη χρηση
EA200701732A1 (ru) Высокоэффективные полные и частичные агонисты и антагонисты рецептора ноцицептина/орфанина fq
DE602005010578D1 (de) Selektive peptidische agonisten des vpac2-rezeptors
WO2008120263A3 (en) Prokineticins receptors antagonists, derivatives and uses thereof
EA201201528A1 (ru) Комбинация ингибиторов ксантиноксидазы и антагонистов рецепторов ангиотензина-ii и ее применение
WO2007140551A3 (en) Treatment of cnidaria intoxication with vanilloid receptor antagonists

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU