ATE519498T1 - Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen - Google Patents
Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypenInfo
- Publication number
- ATE519498T1 ATE519498T1 AT07703319T AT07703319T ATE519498T1 AT E519498 T1 ATE519498 T1 AT E519498T1 AT 07703319 T AT07703319 T AT 07703319T AT 07703319 T AT07703319 T AT 07703319T AT E519498 T1 ATE519498 T1 AT E519498T1
- Authority
- AT
- Austria
- Prior art keywords
- somatostatin
- combination
- receptor subtypes
- analogas
- different selectivity
- Prior art date
Links
- 101000632994 Homo sapiens Somatostatin Proteins 0.000 title abstract 2
- 102000005157 Somatostatin Human genes 0.000 title abstract 2
- 108010056088 Somatostatin Proteins 0.000 title abstract 2
- 102000045305 human SST Human genes 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title abstract 2
- 229960000553 somatostatin Drugs 0.000 title abstract 2
- 101000633010 Rattus norvegicus Somatostatin Proteins 0.000 abstract 1
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NHXLMOGPVYXJNR-UHFFFAOYSA-N srif Chemical compound N1C(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC=2C3=CC=CC=C3NC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC=2C=CC=CC=2)NC(=O)C(CC(N)=O)NC(=O)C(CCCCN)NC(=O)C(NC(=O)CNC(=O)C(C)N)CSSCC(C(O)=O)NC(=O)C(CO)NC(=O)C(C(O)C)NC(=O)C1CC1=CC=CC=C1 NHXLMOGPVYXJNR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602639.7A GB0602639D0 (en) | 2006-02-09 | 2006-02-09 | Organic compounds |
| PCT/EP2007/001036 WO2007096055A1 (en) | 2006-02-09 | 2007-02-07 | Combination of somatostatin-analogs with different selectivity for human somatostatin receptor subtypes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519498T1 true ATE519498T1 (de) | 2011-08-15 |
Family
ID=36119810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07703319T ATE519498T1 (de) | 2006-02-09 | 2007-02-07 | Kombination aus somatostatin-analoga unterschiedlicher selektivität für humane somatostatin-rezeptor-subtypen |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8450272B2 (de) |
| EP (1) | EP1988914B1 (de) |
| JP (1) | JP5189993B2 (de) |
| KR (1) | KR101466410B1 (de) |
| CN (1) | CN101378775B (de) |
| AT (1) | ATE519498T1 (de) |
| AU (1) | AU2007218297B2 (de) |
| BR (1) | BRPI0707560B8 (de) |
| CA (1) | CA2638065C (de) |
| ES (1) | ES2369155T3 (de) |
| GB (1) | GB0602639D0 (de) |
| PL (1) | PL1988914T3 (de) |
| PT (1) | PT1988914E (de) |
| RU (1) | RU2451520C2 (de) |
| WO (1) | WO2007096055A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101245022B1 (ko) | 2005-01-21 | 2013-03-19 | 카무러스 에이비 | 약제학적 지질 조성물 |
| GB0602639D0 (en) * | 2006-02-09 | 2006-03-22 | Novartis Ag | Organic compounds |
| DK2310042T3 (da) | 2008-07-08 | 2013-03-04 | Novartis Ag | Anvendelse af pasireotid til behandling af endogen hyperinsulinæmisk hypoglykæmi |
| ES2834318T3 (es) * | 2012-05-25 | 2021-06-17 | Camurus Ab | Formulaciones de agonistas de receptores de la somatostatina |
| TWI633887B (zh) * | 2012-05-31 | 2018-09-01 | 大塚製藥股份有限公司 | 用於預防及／或治療多囊性腎臟病之藥物 |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| DK3007704T3 (da) * | 2013-06-13 | 2021-03-29 | Antisense Therapeutics Ltd | Kombinationsterapi til akromegali |
| CN120131956A (zh) * | 2023-12-11 | 2025-06-13 | 中山大学中山眼科中心 | 生长激素抑制剂的用途、和含有生长激素抑制剂的药物组合物、制剂、及其装置 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2774591B1 (fr) * | 1998-02-12 | 2000-05-05 | Lipha | Composition pharmaceutique comprenant l'association metformine et fibrate et son utilisation pour la preparation de medicaments destines a reduire l'hyperglycemie |
| GB0018891D0 (en) * | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| EP1813625B1 (de) * | 2001-03-06 | 2009-04-29 | Il Consorzio Ferrara Richerche | Verfahren zur Modulation der Proliferation von Schilddrüsenkrebszellen |
| PL374174A1 (en) * | 2001-06-25 | 2005-10-03 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof |
| AR037665A1 (es) * | 2001-11-21 | 2004-12-01 | Sod Conseils Rech Applic | Analogo de somatostatina y sus usos |
| WO2005041901A2 (en) * | 2003-11-03 | 2005-05-12 | Elixir Pharmaceuticals, Inc. | Therapeutics using somatostatin agonists |
| US7842654B2 (en) * | 2003-12-03 | 2010-11-30 | The Procter & Gamble Company | Method, articles and compositions for cleaning bathroom surfaces |
| ATE549011T1 (de) * | 2005-11-10 | 2012-03-15 | Chemi Spa | Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten |
| GB0602639D0 (en) * | 2006-02-09 | 2006-03-22 | Novartis Ag | Organic compounds |
-
2006
- 2006-02-09 GB GBGB0602639.7A patent/GB0602639D0/en not_active Ceased
-
2007
- 2007-02-07 CA CA2638065A patent/CA2638065C/en active Active
- 2007-02-07 ES ES07703319T patent/ES2369155T3/es active Active
- 2007-02-07 AT AT07703319T patent/ATE519498T1/de active
- 2007-02-07 CN CN2007800049919A patent/CN101378775B/zh active Active
- 2007-02-07 BR BRPI0707560A patent/BRPI0707560B8/pt active IP Right Grant
- 2007-02-07 PT PT07703319T patent/PT1988914E/pt unknown
- 2007-02-07 JP JP2008553675A patent/JP5189993B2/ja active Active
- 2007-02-07 RU RU2008136073/15A patent/RU2451520C2/ru active
- 2007-02-07 EP EP07703319A patent/EP1988914B1/de active Active
- 2007-02-07 US US12/162,715 patent/US8450272B2/en active Active
- 2007-02-07 WO PCT/EP2007/001036 patent/WO2007096055A1/en not_active Ceased
- 2007-02-07 KR KR1020087019493A patent/KR101466410B1/ko active Active
- 2007-02-07 AU AU2007218297A patent/AU2007218297B2/en active Active
- 2007-02-07 PL PL07703319T patent/PL1988914T3/pl unknown
-
2013
- 2013-04-30 US US13/873,289 patent/US9149510B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101378775A (zh) | 2009-03-04 |
| AU2007218297B2 (en) | 2010-09-09 |
| JP5189993B2 (ja) | 2013-04-24 |
| JP2009526002A (ja) | 2009-07-16 |
| CA2638065C (en) | 2016-03-29 |
| ES2369155T3 (es) | 2011-11-25 |
| AU2007218297A1 (en) | 2007-08-30 |
| KR20080106896A (ko) | 2008-12-09 |
| US9149510B2 (en) | 2015-10-06 |
| BRPI0707560B8 (pt) | 2021-05-25 |
| BRPI0707560A2 (pt) | 2011-05-10 |
| CA2638065A1 (en) | 2007-08-30 |
| PT1988914E (pt) | 2011-10-18 |
| PL1988914T3 (pl) | 2012-01-31 |
| GB0602639D0 (en) | 2006-03-22 |
| CN101378775B (zh) | 2013-06-12 |
| EP1988914A1 (de) | 2008-11-12 |
| BRPI0707560B1 (pt) | 2019-06-04 |
| RU2451520C2 (ru) | 2012-05-27 |
| US20130237480A1 (en) | 2013-09-12 |
| KR101466410B1 (ko) | 2014-11-27 |
| WO2007096055A1 (en) | 2007-08-30 |
| RU2008136073A (ru) | 2010-03-20 |
| US20090029910A1 (en) | 2009-01-29 |
| EP1988914B1 (de) | 2011-08-10 |
| US8450272B2 (en) | 2013-05-28 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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