EA200501633A1 - Новые полиморфные формы оланзапина гидрохлорида - Google Patents

Новые полиморфные формы оланзапина гидрохлорида

Info

Publication number
EA200501633A1
EA200501633A1 EA200501633A EA200501633A EA200501633A1 EA 200501633 A1 EA200501633 A1 EA 200501633A1 EA 200501633 A EA200501633 A EA 200501633A EA 200501633 A EA200501633 A EA 200501633A EA 200501633 A1 EA200501633 A1 EA 200501633A1
Authority
EA
Eurasian Patent Office
Prior art keywords
polymorphic forms
new polymorphic
hydrochloride
olanzapine
new
Prior art date
Application number
EA200501633A
Other languages
English (en)
Other versions
EA008376B1 (ru
Inventor
Янош Пето
Йожеф Баркоци
Петер Котаи Надь
Дьюла Шимиг
Жужа Сент-Кирайи
Original Assignee
Эгиш Дьёдьсердьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Рт. filed Critical Эгиш Дьёдьсердьяр Рт.
Publication of EA200501633A1 publication Critical patent/EA200501633A1/ru
Publication of EA008376B1 publication Critical patent/EA008376B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к новым кристаллическим формам I, II и III 2-метил-4-(4-метилпиперазин-1-ил)-10H-тиено-[2,3-b][1,5]-бензодиазепина гидрохлорида, способу их получения и содержащим их фармацевтическим композициям. Эти новые полиморфные формы полезны в качестве активных ингредиентов при лечении психотических состояний.
EA200501633A 2003-04-22 2004-04-22 Новые полиморфные формы оланзапина гидрохлорида EA008376B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0301082A HU226410B1 (en) 2003-04-22 2003-04-22 Novel polymorphous forms of olanzapine hydrochlorides, process for producing them, use thereof and pharmaceutical compositions containing them
PCT/HU2004/000042 WO2004094433A1 (en) 2003-04-22 2004-04-22 New polymorphs of olanzapine hydrochloride

Publications (2)

Publication Number Publication Date
EA200501633A1 true EA200501633A1 (ru) 2006-04-28
EA008376B1 EA008376B1 (ru) 2007-04-27

Family

ID=89981318

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501633A EA008376B1 (ru) 2003-04-22 2004-04-22 Новые полиморфные формы оланзапина гидрохлорида

Country Status (24)

Country Link
US (1) US7951798B2 (ru)
EP (1) EP1620439B1 (ru)
JP (1) JP4763594B2 (ru)
KR (1) KR20060004954A (ru)
CN (2) CN101468999B (ru)
AT (1) ATE401332T1 (ru)
AU (1) AU2004232544B2 (ru)
BG (1) BG109361A (ru)
CA (1) CA2522734C (ru)
CZ (1) CZ2005684A3 (ru)
DE (1) DE602004015096D1 (ru)
DK (1) DK1620439T3 (ru)
EA (1) EA008376B1 (ru)
ES (1) ES2310728T3 (ru)
HR (1) HRP20080479T3 (ru)
HU (1) HU226410B1 (ru)
IL (1) IL171522A (ru)
PL (2) PL1620439T3 (ru)
PT (1) PT1620439E (ru)
SI (1) SI1620439T1 (ru)
SK (1) SK50942005A3 (ru)
UA (1) UA80881C2 (ru)
WO (1) WO2004094433A1 (ru)
ZA (1) ZA200508936B (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003300324A1 (en) * 2002-12-24 2004-07-22 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
SI21850A (sl) * 2004-07-28 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Soli olanzapina in njihova pretvorba v prosto bazo olanzapina
ES2526092T3 (es) * 2004-11-16 2015-01-05 Alkermes Pharma Ireland Limited Formulaciones de olanzapina en nanopartículas inyectables
HUP0501046A2 (en) 2005-11-11 2007-08-28 Egis Gyogyszergyar Nyilvanosan Process for the preparation of olanzapine
PL2081921T3 (pl) * 2006-07-10 2011-03-31 Paion Uk Ltd Krótko działające sole benzodiazepiny i ich formy polimorficzne
WO2008151430A1 (en) * 2007-06-14 2008-12-18 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
US20090286294A1 (en) * 2008-04-04 2009-11-19 University Of Massachusetts Methods and Compositions for Improving the Production of Fuels in Microorganisms
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
WO2013009517A1 (en) * 2011-07-08 2013-01-17 Eli Lilly And Company (THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS
KR101735458B1 (ko) * 2013-01-14 2017-05-15 일라이 릴리 앤드 캄파니 이중 활성 H1 역 효능제/5-HT2A 길항제로서의 (티에노[2,3-b][1,5]벤족사제핀-4-일)피페라진-1-일 화합물
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
KR101489062B1 (ko) * 2013-03-28 2015-02-02 동아에스티 주식회사 고순도의 올란자핀 및 이의 결정형 ii의 제조방법
JP6940866B2 (ja) * 2017-06-21 2021-09-29 国立研究開発法人情報通信研究機構 半導体光デバイス、半導体光源、光集積回路、及び半導体光デバイスの製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
CA2304568C (en) * 1997-09-30 2008-08-12 Eli Lilly And Company Olanzapine pamoate formulations
CN1146422C (zh) * 1998-09-30 2004-04-21 伊莱利利公司 2-甲基-噻吩并-苯并二氮杂�制剂
UA80095C2 (en) 2001-07-20 2007-08-27 Lilly Co Eli 2 methyl-thieno-benzodiazepine lyophilized formulation and method for the preparation thereof
ATE504588T1 (de) * 2004-01-27 2011-04-15 Synthon Bv Stabile salze von olanzapin

Also Published As

Publication number Publication date
AU2004232544A1 (en) 2004-11-04
PL378061A1 (pl) 2006-02-20
DK1620439T3 (da) 2008-11-17
ES2310728T3 (es) 2009-01-16
US7951798B2 (en) 2011-05-31
ATE401332T1 (de) 2008-08-15
EP1620439A1 (en) 2006-02-01
WO2004094433A1 (en) 2004-11-04
PT1620439E (pt) 2008-10-23
US20070004706A1 (en) 2007-01-04
CN101468999A (zh) 2009-07-01
SK50942005A3 (sk) 2006-02-02
HU226410B1 (en) 2008-11-28
CA2522734A1 (en) 2004-11-04
CN101468999B (zh) 2012-05-09
CN1777613A (zh) 2006-05-24
CN100471859C (zh) 2009-03-25
PL1620439T3 (pl) 2009-02-27
CZ2005684A3 (cs) 2006-01-11
BG109361A (bg) 2006-09-29
IL171522A (en) 2010-05-31
SI1620439T1 (sl) 2009-06-30
HU0301082D0 (en) 2003-06-28
AU2004232544B2 (en) 2010-06-03
JP4763594B2 (ja) 2011-08-31
HRP20080479T3 (en) 2008-10-31
EP1620439B1 (en) 2008-07-16
JP2006524219A (ja) 2006-10-26
DE602004015096D1 (de) 2008-08-28
CA2522734C (en) 2010-05-25
ZA200508936B (en) 2008-07-30
HUP0301082A2 (hu) 2004-12-28
UA80881C2 (en) 2007-11-12
KR20060004954A (ko) 2006-01-16
EA008376B1 (ru) 2007-04-27

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ MD RU