EA200600064A1 - Производные тиенопиридона как ингибиторы киназ - Google Patents

Производные тиенопиридона как ингибиторы киназ

Info

Publication number
EA200600064A1
EA200600064A1 EA200600064A EA200600064A EA200600064A1 EA 200600064 A1 EA200600064 A1 EA 200600064A1 EA 200600064 A EA200600064 A EA 200600064A EA 200600064 A EA200600064 A EA 200600064A EA 200600064 A1 EA200600064 A1 EA 200600064A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kinase inhibitors
derivatives
thienopyridone derivatives
thienopyridone
thieno
Prior art date
Application number
EA200600064A
Other languages
English (en)
Other versions
EA010297B1 (ru
Inventor
Дэниел Кристофер Брукинс
Джереми Мартин Дэвис
Бэрри Джон Ленгхэм
Original Assignee
Селлтек Р & Д Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0314492A external-priority patent/GB0314492D0/en
Priority claimed from GB0329485A external-priority patent/GB0329485D0/en
Application filed by Селлтек Р & Д Лимитед filed Critical Селлтек Р & Д Лимитед
Publication of EA200600064A1 publication Critical patent/EA200600064A1/ru
Publication of EA010297B1 publication Critical patent/EA010297B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Описан ряд производных тиено [2,3-b]пиридин-6-(7Н)-она, замещенных в 2-положении карбонил- или сульфонилсвязанным пирролидин-1-ильным или родственным с ним остатком, являющихся ингибиторами р38 MAP киназы, которые могут соответственно использоваться в медицине, например, при лечении и/или профилактике иммунных или воспалительных заболеваний.
EA200600064A 2003-06-20 2004-06-18 Производные тиенопиридона как ингибиторы киназ EA010297B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0314492A GB0314492D0 (en) 2003-06-20 2003-06-20 Chemical compounds
GB0329485A GB0329485D0 (en) 2003-12-19 2003-12-19 Chemical compounds
PCT/GB2004/002621 WO2004113347A1 (en) 2003-06-20 2004-06-18 Thienopyridone derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200600064A1 true EA200600064A1 (ru) 2006-08-25
EA010297B1 EA010297B1 (ru) 2008-08-29

Family

ID=33542685

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600064A EA010297B1 (ru) 2003-06-20 2004-06-18 Производные тиенопиридона как ингибиторы киназ

Country Status (12)

Country Link
US (1) US7521460B2 (ru)
EP (1) EP1641804A1 (ru)
JP (1) JP2007516161A (ru)
KR (1) KR20060021905A (ru)
AU (1) AU2004249495A1 (ru)
BR (1) BRPI0410653A (ru)
CA (1) CA2528602A1 (ru)
EA (1) EA010297B1 (ru)
IL (1) IL172132A0 (ru)
MX (1) MXPA05013227A (ru)
NO (1) NO20060279L (ru)
WO (1) WO2004113347A1 (ru)

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* Cited by examiner, † Cited by third party
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GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
EP1638979A1 (en) * 2003-06-20 2006-03-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
JP2007509123A (ja) * 2003-10-24 2007-04-12 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノ−ピリジノン誘導体
EP2591784B1 (en) 2005-05-10 2016-09-14 Intermune, Inc. Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
CN104892582B (zh) 2005-10-07 2019-09-27 埃克塞利希斯股份有限公司 作为用于治疗增生性疾病的mek抑制剂的吖丁啶
AU2006318428A1 (en) * 2005-11-23 2007-05-31 Intermune, Inc. Method of modulating stress-activated protein kinase system
GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
EP2004656B1 (en) 2006-04-07 2013-07-10 Boehringer Ingelheim International GmbH Thienopyrimidines having mnk1 /mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
WO2008064829A2 (en) * 2006-11-30 2008-06-05 Ucb Pharma, S.A. Novel aminothienopyridinone derivatives processes for preparing them and pharmaceutical compositions thereof
JP5311673B2 (ja) * 2006-12-14 2013-10-09 エグゼリクシス， インコーポレイテッド Ｍｅｋ阻害剤の使用方法
WO2008124085A2 (en) * 2007-04-03 2008-10-16 Exelixis, Inc. Methods of using combinations of mek and jak-2 inhibitors
GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
GB0811304D0 (en) 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
WO2010023181A1 (en) 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
CA2791114A1 (en) 2010-02-26 2011-09-01 Boehringer Ingelheim International Gmbh Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
WO2011104334A1 (en) 2010-02-26 2011-09-01 Boehringer Ingelheim International Gmbh 4 - [cycloalkyloxy (hetero) arylamino] thieno [2, 3 - d] pyrimidines having mnkl/ mnk2 inhibiting activity for pharmaceutical compositions
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
WO2014059422A1 (en) 2012-10-12 2014-04-17 Exelixis, Inc. Novel process for making compounds for use in the treatment of cancer
MX368078B (es) * 2012-11-21 2019-09-17 Zoetis Llc Sintesis de derivados de isoxazolina espirociclicos.
WO2014100755A2 (en) 2012-12-20 2014-06-26 Biomatrica, Inc. Formulations and methods for stabilizing pcr reagents
WO2015002729A2 (en) 2013-06-13 2015-01-08 Biomatrica, Inc. Cell stabilization
KR102373700B1 (ko) 2014-04-02 2022-03-11 인터뮨, 인크. 항섬유성 피리디논
CN113826612B (zh) 2014-06-10 2022-11-22 生物马特里卡公司 在环境温度下稳定凝血细胞
EP4242628A3 (en) 2015-12-08 2023-11-08 Biomatrica, INC. Reduction of erythrocyte sedimentation rate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048863A (en) * 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
EP1086085A1 (en) * 1998-06-12 2001-03-28 Vertex Pharmaceuticals Incorporated INHIBITORS OF p38
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
EP1638979A1 (en) * 2003-06-20 2006-03-29 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors
JP2007509123A (ja) * 2003-10-24 2007-04-12 セルテック アール アンド ディ リミテッド キナーゼ阻害剤としてのチエノ−ピリジノン誘導体

Also Published As

Publication number Publication date
CA2528602A1 (en) 2004-12-29
EP1641804A1 (en) 2006-04-05
US20070099894A1 (en) 2007-05-03
EA010297B1 (ru) 2008-08-29
NO20060279L (no) 2006-03-20
BRPI0410653A (pt) 2006-07-04
JP2007516161A (ja) 2007-06-21
US7521460B2 (en) 2009-04-21
MXPA05013227A (es) 2006-03-09
AU2004249495A1 (en) 2004-12-29
IL172132A0 (en) 2006-04-10
WO2004113347A1 (en) 2004-12-29
KR20060021905A (ko) 2006-03-08

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU