EA200500850A1 - Непэгилированные, длительно циркулирующие липосомы - Google Patents

Непэгилированные, длительно циркулирующие липосомы

Info

Publication number
EA200500850A1
EA200500850A1 EA200500850A EA200500850A EA200500850A1 EA 200500850 A1 EA200500850 A1 EA 200500850A1 EA 200500850 A EA200500850 A EA 200500850A EA 200500850 A EA200500850 A EA 200500850A EA 200500850 A1 EA200500850 A1 EA 200500850A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phospholipid
sucrose
liposomes
long
unpegylated
Prior art date
Application number
EA200500850A
Other languages
English (en)
Other versions
EA008930B1 (ru
Inventor
Гаутам Винод Дафтари
Срикантх Аннаппа Паи
Санджита Ханурмеш Риванкар
Original Assignee
Бхарат Сирумс Энд Вэксинс Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бхарат Сирумс Энд Вэксинс Лтд. filed Critical Бхарат Сирумс Энд Вэксинс Лтд.
Publication of EA200500850A1 publication Critical patent/EA200500850A1/ru
Publication of EA008930B1 publication Critical patent/EA008930B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение обеспечивает композицию длительно циркулирующих, непэгилированных липосом с доксорубицином для парентерального введения и способ ее получения. Время циркуляции у мышей swiss albino по меньшей мере в 25 раз превышает время циркуляции обычных нелипосомных композиций. Непэгилированные липосомы являются стабильными, проявляют низкую токсичность и, как было обнаружено, являются эффективными для различных моделей опухолей.Отчет о международном поиске был опубликован 2004.10.28.
EA200500850A 2002-12-31 2003-12-31 Непэгилированные, длительно циркулирующие липосомы EA008930B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1101MU2002 2002-12-31
PCT/IN2003/000424 WO2004058140A2 (en) 2002-12-31 2003-12-31 Non-pegylated long-circulating liposomes

Publications (2)

Publication Number Publication Date
EA200500850A1 true EA200500850A1 (ru) 2006-02-24
EA008930B1 EA008930B1 (ru) 2007-08-31

Family

ID=32500467

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500850A EA008930B1 (ru) 2002-12-31 2003-12-31 Непэгилированные, длительно циркулирующие липосомы

Country Status (19)

Country Link
EP (1) EP1435231B8 (ru)
JP (1) JP5355842B2 (ru)
KR (2) KR101133084B1 (ru)
CN (1) CN1756533B (ru)
AT (1) ATE453381T1 (ru)
AU (1) AU2003303368B2 (ru)
BR (1) BR0317882A (ru)
CA (1) CA2511464C (ru)
DE (1) DE60330745D1 (ru)
DK (1) DK1435231T3 (ru)
EA (1) EA008930B1 (ru)
ES (1) ES2337563T3 (ru)
HK (1) HK1089946A1 (ru)
IL (1) IL169364A (ru)
MX (1) MXPA05007102A (ru)
NZ (1) NZ540778A (ru)
PT (1) PT1435231E (ru)
WO (1) WO2004058140A2 (ru)
ZA (1) ZA200504850B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5634862B2 (ja) * 2007-05-16 2014-12-03 カーテーベー トゥモーアフォルシュングス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低粘度アントラサイクリン製剤
DK2415470T3 (en) 2009-03-30 2016-09-19 Eisai R&D Man Co Ltd liposome
JP5622719B2 (ja) 2009-03-30 2014-11-12 エーザイ・アール・アンド・ディー・マネジメント株式会社 リポソーム組成物の製造方法
EP2680820B1 (en) * 2011-03-01 2022-11-02 2-BBB Medicines B.V. Advanced active liposomal loading of poorly water-soluble substances
KR20190062485A (ko) * 2016-09-27 2019-06-05 버텍스 파마슈티칼스 인코포레이티드 Dna-손상제 및 dna-pk 저해제의 조합을 사용한 암 치료 방법
US11083705B2 (en) 2019-07-26 2021-08-10 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumor
CN116570775A (zh) * 2023-05-16 2023-08-11 万瑞飞鸿(北京)医疗器材有限公司 一种药物涂层、血管支架及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
WO1985000968A1 (en) * 1983-09-06 1985-03-14 Health Research, Inc. Liposome delivery method for decreasing the toxicity of an antitumor drug
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
JPH0720857B2 (ja) 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US6132763A (en) 1988-10-20 2000-10-17 Polymasc Pharmaceuticals Plc Liposomes
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
AU714992B2 (en) * 1996-08-23 2000-01-13 Alza Corporation Liposomes containing a cisplatin compound
BR9914601A (pt) * 1998-09-16 2001-10-23 Alza Corp Inibidor de topoisomerase capturado por lipossoma
KR20000061075A (ko) * 1999-03-23 2000-10-16 린 중친 리포솜의 응집을 방지하기 위한 방법 및 조성물
GB0111279D0 (en) * 2001-05-10 2001-06-27 Nycomed Imaging As Radiolabelled liposomes

Also Published As

Publication number Publication date
EP1435231B1 (en) 2009-12-30
WO2004058140B1 (en) 2004-12-16
BR0317882A (pt) 2005-12-13
CA2511464C (en) 2011-08-23
ZA200504850B (en) 2006-08-30
AU2003303368B2 (en) 2010-06-17
ATE453381T1 (de) 2010-01-15
JP2006513189A (ja) 2006-04-20
KR20110075051A (ko) 2011-07-05
EA008930B1 (ru) 2007-08-31
CA2511464A1 (en) 2004-07-15
AU2003303368A1 (en) 2004-07-22
DE60330745D1 (de) 2010-02-11
MXPA05007102A (es) 2005-08-26
HK1089946A1 (en) 2006-12-15
WO2004058140A3 (en) 2004-10-28
DK1435231T3 (da) 2010-04-26
KR101171045B1 (ko) 2012-08-03
PT1435231E (pt) 2010-04-08
NZ540778A (en) 2008-04-30
ES2337563T3 (es) 2010-04-27
CN1756533B (zh) 2010-06-16
JP5355842B2 (ja) 2013-11-27
CN1756533A (zh) 2006-04-05
EP1435231B8 (en) 2010-03-03
WO2004058140A2 (en) 2004-07-15
IL169364A (en) 2012-05-31
KR20050088233A (ko) 2005-09-02
KR101133084B1 (ko) 2012-04-04
EP1435231A1 (en) 2004-07-07
IL169364A0 (en) 2007-07-04

Similar Documents

Publication Publication Date Title
HK1089946A1 (en) Non-pegylated long-circulating liposomes
ITMI991803A0 (it) Processo per la preparazione di formulazioni acquose per uso oftalmico
CY1105707T1 (el) Συνδυασμοι φορμοτερολης και ενος αλατος τριοτροπιου
HK1062140A1 (en) 4-fluoro-n-indan-2-yl benzamide and its use as pharmaceutical 4-n-(1,2-2-?)
MY131810A (en) Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
BRPI0411677A (pt) métodos de uso de compostos heterocìclicos [3.2.0] e seus análogos
IL168279A (en) Use of liposomal and aminoglycoside composition to prepare a drug for the treatment or improvement of infection
RU2005138915A (ru) Сульфонамид замещенные имидазохинолины
AR002262A1 (es) Composicion y metodo para el tratamiento de enfermedades fungales de las unas y un vendaje adaptado para la administracion topica de medicacion a lasunas.
EA200300457A1 (ru) Кристаллический моногидрат, способ его получения и его применение для получения лекарственного средства
BR0117106A (pt) Compostos de lipossoma de microesfera de gás
RU2210573C2 (ru) Углеводные производные
IT8812585A0 (it) Preparato, in particolare preparato cosmetico antisolare, nonche' metodo per l'introduzione di una sostanza attiva nella pelle
ATE248187T1 (de) Echinocandin-kohlenhydrate-komplexe
RU99124771A (ru) Применение альфа-метил-п-тирозина для ингибирования продуцирования меланина в меланоцитах радужной оболочки
EP2207555A1 (en) Novel compounds for the treatment or alleviation of edema, and methods for their use
AR006892A1 (es) Uso de formas del acido hialuronico (ha) para el tratamiento del cancer
CO4960654A1 (es) Metodo para el tratamiento de enfermedades fisiologicas relacionadas con el uso o con las secuelas provocadas por el uso de la cocaina u otros estimulantes psicomotores
BR9917389A (pt) Formulações tópicas compreendendo agentes de penetração na pele e o uso das mesmas
IT1296305B1 (it) Inibitori di metalloproteinasi loro uso terapeutico e procedimento per la produzione del composto di partenza nella loro
ES2036661T3 (es) Un metodo para preparar una preparacion farmaceutica de pie de atleta.
CA2241825A1 (en) New monofunctionalized edta, dtpa and ttha derivatives and their use in medical diagnosis and therapy
RU2003104017A (ru) Ингибиторы тромбина, содержащие аминоизохинолиновую группу
CO5180574A1 (es) Micofenolato mofetil en asociacion con peg-inf-a
BRPI0407304A (pt) Agentes antibacterianos

Legal Events

Date Code Title Description
PC1A Registration of transfer to a eurasian application by force of assignment
HC1A Change in name of an applicant in a eurasian application
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU