EA200500648A1 - Галогенированные селективные модуляторы андрогеновых рецепторов и способы их применения - Google Patents

Галогенированные селективные модуляторы андрогеновых рецепторов и способы их применения

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EA200500648A1
EA200500648A1 EA200500648A EA200500648A EA200500648A1 EA 200500648 A1 EA200500648 A1 EA 200500648A1 EA 200500648 A EA200500648 A EA 200500648A EA 200500648 A EA200500648 A EA 200500648A EA 200500648 A1 EA200500648 A1 EA 200500648A1
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subject
methods
application
androgen receptors
chf
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EA200500648A
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English (en)
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EA011744B1 (ru
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Джеймс Т. Долтон
Дуэйн Д. Миллер
Донгхуа Йин
Яли Хе
Митчелл С. Стейнер
Карен А. Веверка
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Юниверсити Оф Теннесси Рисерч Фаундейшн
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Priority claimed from US10/270,732 external-priority patent/US6998500B2/en
Application filed by Юниверсити Оф Теннесси Рисерч Фаундейшн filed Critical Юниверсити Оф Теннесси Рисерч Фаундейшн
Publication of EA200500648A1 publication Critical patent/EA200500648A1/ru
Publication of EA011744B1 publication Critical patent/EA011744B1/ru

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Abstract

Настоящее изобретение предоставляет класс веществ, направленных на андрогеновые рецепторы (ARTA). Эти вещества определяют новый подкласс соединений, являющихся селективными модуляторами андрогеновых рецепторов (SARM). Некоторые соединения SARM, как оказалось, обладают неожиданной андрогенной и анаболической активностью нестероидных лигандов андрогеновых рецепторов. Другие соединения SARM, как оказалось, обладают неожиданной антиандрогенной активностью нестероидных лигандов андрогеновых рецепторов. Соединения SARM, сами по себе или в виде композиции, применимы для: а) мужской контрацепции; b) лечения целого ряда гормонзависимых расстройств, например расстройств, связанных с возрастным снижением уровня андрогенов у мужчин (ADAM), таких как усталость, депрессия, пониженное либидо, половая дисфункция, нарушения эрекции, гипогонадизм, остеопороз, выпадение волос, анемия, ожирение, саркопения, остеопения, остеопороз, доброкачественная гиперплазия простаты, изменения настроения и сознания и рак простаты; с) лечения расстройств, связанных со снижением уровня андрогенов у женщин (ADIF), таких как половая дисфункция, пониженное сексуальное либидо, гипогонадизм, саркопения, остеопения, остеопороз, изменения в сознании и настроении, депрессия, анемия, выпадение волос, ожирение, эндометриоз, рак молочной железы, рак матки и рак яичников; d) лечения и/или предупреждения острой и/или хронической гипотрофии мышц; е) предупреждения и/или лечения сухости глаз; f) пероральной андроген-заместительной терапии; g) снижения встречаемости, приостановки или регрессии рака простаты; и/или h) индукции апоптоза в раковых клетках.
EA200500648A 2002-10-16 2003-10-14 Галогенированные селективные модуляторы андрогеновых рецепторов и способы их применения EA011744B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/270,732 US6998500B2 (en) 2000-08-24 2002-10-16 Selective androgen receptor modulators and methods of use thereof
US10/371,213 US7026500B2 (en) 2000-08-24 2003-02-24 Halogenated selective androgen receptor modulators and methods of use thereof
PCT/US2003/032507 WO2004035736A2 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof

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EA200500648A1 true EA200500648A1 (ru) 2006-06-30
EA011744B1 EA011744B1 (ru) 2009-06-30

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EA200500648A EA011744B1 (ru) 2002-10-16 2003-10-14 Галогенированные селективные модуляторы андрогеновых рецепторов и способы их применения
EA200700854A EA014932B1 (ru) 2002-10-16 2003-10-14 Способы лечения состояний, связанных с падением уровня андрогенов у женщин (adif)

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