ES2194690T3 - Procedimiento de preparacion de oxazoles trisustituidos. - Google Patents

Procedimiento de preparacion de oxazoles trisustituidos.

Info

Publication number
ES2194690T3
ES2194690T3 ES00402697T ES00402697T ES2194690T3 ES 2194690 T3 ES2194690 T3 ES 2194690T3 ES 00402697 T ES00402697 T ES 00402697T ES 00402697 T ES00402697 T ES 00402697T ES 2194690 T3 ES2194690 T3 ES 2194690T3
Authority
ES
Spain
Prior art keywords
oxazoles
preparation
trisustituidos
procedure
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00402697T
Other languages
English (en)
Inventor
Maria Dalko
Jacqueline Dumats
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Application granted granted Critical
Publication of ES2194690T3 publication Critical patent/ES2194690T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento de preparación de oxazoles trisustituidos de fórmula (II): **FORMULA** por reacción de tiourea sobre el diceton-éster correspondiente de fórmula (I): **FORMULA** en las cuales los radicales R1, R2 y R3, idénticos o diferentes, pueden escogerse entre: - radicales hidrocarbonados lineales o ramificados, saturados o insaturados, C1-C12, opcionalmente sustituidos por -OR, -SR, -NRR¿, -COOR, -CN, -SOnCH3, -CF3 y/o halógeno, con R y R¿, idénticos o diferentes, representando hidrógeno, un radical hidrocarbonado lineal, ramificado o cíclico, saturado o insaturado C1-C12 y n = 0, 1 ó 2; - radicales arilos opcionalmente sustituidos por un radical hidrocarbonado lineal o ramificado, saturado o insaturado, C1-C12, un radical -OR, -NRR¿, -COOR, -CN, -SOnCH3, -SR, -CF3 y/o halógeno, teniendo R, R¿ y n los mismos significados dados anteriormente, y/o - radicales heterocíclicos C5-10, saturados o insaturados, que contienen al menos un heteroátomo escogido entere N, S y/o, opcionalmente sustituidos por un radical hidrocarbonado lineal o ramificado C1-C12, un radical -OR, -NRR¿, -COOR, -CN, -SOnCH3, -SR, -CF3 y/o halógeno, teniendo R, R¿ y n los mismos significados dados aquí anteriormente, efectuándose la reacción en DMF (dimetilformamida).
ES00402697T 1999-10-27 2000-09-29 Procedimiento de preparacion de oxazoles trisustituidos. Expired - Lifetime ES2194690T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9913446A FR2800373B1 (fr) 1999-10-27 1999-10-27 Procede de preparation d'oxazoles trisubstitues

Publications (1)

Publication Number Publication Date
ES2194690T3 true ES2194690T3 (es) 2003-12-01

Family

ID=9551428

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00402697T Expired - Lifetime ES2194690T3 (es) 1999-10-27 2000-09-29 Procedimiento de preparacion de oxazoles trisustituidos.

Country Status (7)

Country Link
US (1) US6333414B1 (es)
EP (1) EP1095937B1 (es)
AT (1) ATE234293T1 (es)
CA (1) CA2324433A1 (es)
DE (1) DE60001615T2 (es)
ES (1) ES2194690T3 (es)
FR (1) FR2800373B1 (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1206403A (en) * 1966-12-15 1970-09-23 Wyeth John & Brother Ltd Oxazoles
US4632930A (en) * 1984-11-30 1986-12-30 E. I. Du Pont De Nemours And Company Antihypertensive alkyl-arylimidazole, thiazole and oxazole derivatives
FR2663331B1 (fr) * 1990-06-14 1994-05-06 Bellon Laboratoires Nouveaux derives de l'oxazole, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5380738A (en) 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
US6090834A (en) * 1993-05-21 2000-07-18 G.D. Searle & Co. Substituted oxazoles for the treatment of inflammation

Also Published As

Publication number Publication date
FR2800373A1 (fr) 2001-05-04
EP1095937A1 (fr) 2001-05-02
EP1095937B1 (fr) 2003-03-12
CA2324433A1 (fr) 2001-04-27
DE60001615D1 (de) 2003-04-17
DE60001615T2 (de) 2003-09-18
FR2800373B1 (fr) 2001-12-07
US6333414B1 (en) 2001-12-25
ATE234293T1 (de) 2003-03-15

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