EA200500632A1 - Агрегат с повышенной способностью к деформации, содержащий по крайней мере три амфипатических соединения для лучшего проникновения через полунепроницаемые барьеры и для неинвазивного введения лекарственных средств in vivo в особенности через кожу - Google Patents

Агрегат с повышенной способностью к деформации, содержащий по крайней мере три амфипатических соединения для лучшего проникновения через полунепроницаемые барьеры и для неинвазивного введения лекарственных средств in vivo в особенности через кожу

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Publication number
EA200500632A1
EA200500632A1 EA200500632A EA200500632A EA200500632A1 EA 200500632 A1 EA200500632 A1 EA 200500632A1 EA 200500632 A EA200500632 A EA 200500632A EA 200500632 A EA200500632 A EA 200500632A EA 200500632 A1 EA200500632 A1 EA 200500632A1
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Eurasian Patent Office
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application
capacity
area
meated
disciples
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EA200500632A
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English (en)
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EA010407B1 (ru
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Грегор Цевц
Ульрих Виерл
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Идеа Аг
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Priority claimed from US10/357,617 external-priority patent/US7473432B2/en
Application filed by Идеа Аг filed Critical Идеа Аг
Publication of EA200500632A1 publication Critical patent/EA200500632A1/ru
Publication of EA010407B1 publication Critical patent/EA010407B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Данное изобретение относится к комбинации по крайней мере трех амфипатических соединений, формирующих суспензию агрегатов в полярной жидкости. Тщательный выбор соединений для агрегата, растворимость которых различается по меньшей мере в два, а то и в десять раз, гарантирует наличие у указанных агрегатов широкой, необыкновенно пластичной поверхности. Вероятно, это достигается одновременным воздействием на указанный агрегат по меньшей мере двух наиболее растворимых соединений среди упомянутых трех компонентов комбинации, по крайней мере одно из которых является активным ингредиентом, предпочтительно лекарственным средством; третий компонент, альтернативно, также может выполнять роль лекарственного средства. Настоящее изобретение также относится к применению указанных агрегатов в фармацевтических препаратах, предназначенных для доставки лекарственных средств в кровь теплокровных животных. Это становится возможным благодаря высокому насыщению лекарственным средством указанных агрегатов, имеющих чрезвычайно гибкую и эластичную поверхность, которая способствует наличию у конечных лекарственных носителей высокой адаптогенности. Данное изобретение, кроме того, относится к подходящим способам и предпочтительным условиям изготовления и применения носителей. В настоящем изобретении также описываются новые рецептуры нестероидных противовоспалительных средств (НПВС), основанные на смешанных агрегатах, содержащих по крайней мере три амфипатических соединения, растворимых в подходящей, например в фармацевтически доступной, полярной жидкой среде.Международная заявка была опубликована вместе с отчетом
EA200500632A 2002-10-11 2003-10-09 Фармацевтические препараты для проникновения через полунепроницаемые барьеры и для неинвазивного введения лекарственных средств in vivo EA010407B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US41784702P 2002-10-11 2002-10-11
US10/357,617 US7473432B2 (en) 2002-10-11 2003-02-04 NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
US10/357,618 US20040105881A1 (en) 2002-10-11 2003-02-04 Aggregates with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
PCT/EP2003/011202 WO2004032900A1 (en) 2002-10-11 2003-10-09 Aggregate with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin

Publications (2)

Publication Number Publication Date
EA200500632A1 true EA200500632A1 (ru) 2005-12-29
EA010407B1 EA010407B1 (ru) 2008-08-29

Family

ID=32995875

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500632A EA010407B1 (ru) 2002-10-11 2003-10-09 Фармацевтические препараты для проникновения через полунепроницаемые барьеры и для неинвазивного введения лекарственных средств in vivo

Country Status (22)

Country Link
EP (5) EP1551370B1 (ru)
JP (3) JP2006505619A (ru)
KR (1) KR20050055723A (ru)
CN (1) CN1703199B (ru)
AT (1) ATE381316T1 (ru)
AU (1) AU2003273977B2 (ru)
BR (1) BR0315148A (ru)
CA (1) CA2498938A1 (ru)
DE (1) DE60318227T2 (ru)
DK (1) DK1551370T3 (ru)
EA (1) EA010407B1 (ru)
ES (1) ES2298566T3 (ru)
HK (1) HK1079113A1 (ru)
HR (1) HRPK20050421B3 (ru)
IS (1) IS7776A (ru)
MX (1) MXPA05003744A (ru)
NO (1) NO20052281L (ru)
NZ (1) NZ538571A (ru)
PL (1) PL377202A1 (ru)
PT (1) PT1551370E (ru)
SI (1) SI1551370T1 (ru)
WO (1) WO2004032900A1 (ru)

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* Cited by examiner, † Cited by third party
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DK1031347T3 (da) 1999-01-27 2002-07-08 Idea Ag Transnasal transport/immunisering med meget tilpasselige bærere
PT1031346E (pt) 1999-01-27 2002-09-30 Idea Ag Vacinacao nao invasiva atraves da pele
US20080095722A1 (en) * 2004-11-12 2008-04-24 Idea Ag Extended Surface Aggregates in the Treatment of Skin Conditions
CA2698293A1 (en) * 2007-09-13 2009-03-26 Thomas Subkowski Use of hydrophobin polypeptides as penetration intensifiers
PL214538B1 (pl) * 2009-05-28 2013-08-30 P P F Hasco Lek Spolka Akcyjna Kompozycja liposomowa zawierajaca naproksen i sposób wytwarzania kompozycji liposomowej zawierajacej naproksen
CN102639113A (zh) * 2009-06-03 2012-08-15 J·C·梅奥 用于治疗深部组织疼痛的制剂
US20120232034A1 (en) * 2009-08-21 2012-09-13 Henk-Andre Kroon Vesicular formulations
GB2503844A (en) * 2011-03-21 2014-01-08 Gregor Cevc Drug-free compositions and methods for diminishing peripheral inflammation and pain
EP2688554A2 (en) * 2011-03-21 2014-01-29 Gregor Cevc Optimised preparations of highly adaptable aggregates
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
US9823235B2 (en) * 2012-10-26 2017-11-21 Oxford Nanopre Technologies Ltd. Droplet interfaces
RU2524649C1 (ru) * 2013-07-24 2014-07-27 Станислав Анатольевич Кедик Способ получения микросфер для приготовления инъецируемой лекарственной формы диклофенака, композиция и лекарственная форма
KR102325654B1 (ko) * 2013-07-31 2021-11-12 시퀘솜 네크놀로지 홀딩스 리미티드 소포체
WO2015048554A1 (en) * 2013-09-26 2015-04-02 National University Of Singapore Compositions and methods utilizing lysophosphatidylcholine scaffolds
WO2015060446A1 (ja) * 2013-10-25 2015-04-30 凸版印刷株式会社 膜小胞回収デバイス、膜小胞回収方法、及び膜小胞分析方法
PL3316856T3 (pl) 2015-06-30 2021-10-25 Sequessome Technology Holdings Limited Zmieszane formulacje
US20200030457A1 (en) * 2017-04-03 2020-01-30 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR102149190B1 (ko) 2018-04-09 2020-08-28 경상대학교산학협력단 액중 방전 마이크로젯 약물 전달장치
KR20220008824A (ko) 2019-04-17 2022-01-21 컴퍼스 패쓰파인더 리미티드 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법
CA3177454A1 (en) 2020-05-19 2021-11-25 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
KR102209397B1 (ko) 2020-07-21 2021-01-29 경상대학교산학협력단 액중 방전 마이크로젯 약물 전달장치

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Publication number Publication date
EP1815846A2 (en) 2007-08-08
BR0315148A (pt) 2005-08-16
AU2003273977B2 (en) 2007-07-12
CN1703199A (zh) 2005-11-30
HRP20050421A2 (en) 2005-12-31
PL377202A1 (pl) 2006-01-23
DE60318227T2 (de) 2008-12-04
HRPK20050421B3 (en) 2007-06-30
JP2009108070A (ja) 2009-05-21
DK1551370T3 (da) 2008-03-03
EP1829528A2 (en) 2007-09-05
WO2004032900A8 (en) 2005-03-31
NZ538571A (en) 2007-05-31
MXPA05003744A (es) 2005-09-20
EP1551370B1 (en) 2007-12-19
EP1829527A2 (en) 2007-09-05
PT1551370E (pt) 2008-02-07
ES2298566T3 (es) 2008-05-16
HK1079113A1 (en) 2006-03-31
JP2005213261A (ja) 2005-08-11
WO2004032900A1 (en) 2004-04-22
EP1829527A3 (en) 2008-11-05
SI1551370T1 (sl) 2008-06-30
EP1829528A3 (en) 2008-11-05
NO20052281D0 (no) 2005-05-10
AU2003273977A1 (en) 2004-05-04
EP1815846A3 (en) 2008-10-22
ATE381316T1 (de) 2008-01-15
IS7776A (is) 2005-03-30
KR20050055723A (ko) 2005-06-13
EP1815847A2 (en) 2007-08-08
CA2498938A1 (en) 2004-04-22
CN1703199B (zh) 2010-04-28
NO20052281L (no) 2005-07-07
EA010407B1 (ru) 2008-08-29
JP2006505619A (ja) 2006-02-16
JP4555111B2 (ja) 2010-09-29
DE60318227D1 (de) 2008-01-31
EP1551370A1 (en) 2005-07-13
EP1815847A3 (en) 2008-11-05

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