EA200300550A1 - Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение - Google Patents

Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение

Info

Publication number
EA200300550A1
EA200300550A1 EA200300550A EA200300550A EA200300550A1 EA 200300550 A1 EA200300550 A1 EA 200300550A1 EA 200300550 A EA200300550 A EA 200300550A EA 200300550 A EA200300550 A EA 200300550A EA 200300550 A1 EA200300550 A1 EA 200300550A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
camptotocine
options
preparation
application
Prior art date
Application number
EA200300550A
Other languages
English (en)
Other versions
EA006741B1 (ru
Inventor
Имран Ахмад
Цзя-Ай Чжанг (Аллан)
Аквилар Рахман
Original Assignee
Неофарм, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Неофарм, Инк. filed Critical Неофарм, Инк.
Publication of EA200300550A1 publication Critical patent/EA200300550A1/ru
Publication of EA006741B1 publication Critical patent/EA006741B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Данное изобретение касается новых композиций и способов лечения заболеваний, вызываемых клеточной пролиферацией, в частности лечения рака у млекопитающих и, в особенности, у человека. Терапевтические композиции, соответствующие данному изобретению, включают в себя липидные комплексы SN-38. В композициях комплексы могут содержать любой из множества нейтральных или заряженных липидов и желательно кардиолипин. Композиции обладают способностью эффективного включения SN-38 в комплексы и способны солюбилизировать SN-38 в относительно высоких концентрациях.Отчет о международном поиске был опубликован 2003.08.28.
EA200300550A 2000-11-09 2001-11-09 Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение EA006741B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24730600P 2000-11-09 2000-11-09
PCT/US2001/043325 WO2002058622A2 (en) 2000-11-09 2001-11-09 Sn-38 lipid complexes and methods of use

Publications (2)

Publication Number Publication Date
EA200300550A1 true EA200300550A1 (ru) 2004-06-24
EA006741B1 EA006741B1 (ru) 2006-04-28

Family

ID=22934406

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300550A EA006741B1 (ru) 2000-11-09 2001-11-09 Липидная композиция, содержащая производное камптотецина (варианты), способ её получения и применение

Country Status (22)

Country Link
US (1) US7390502B2 (ru)
EP (1) EP1355634B8 (ru)
JP (1) JP4524071B2 (ru)
KR (1) KR100869824B1 (ru)
CN (1) CN1531424A (ru)
AT (1) ATE413164T1 (ru)
AU (1) AU2002246510B2 (ru)
BG (1) BG107862A (ru)
BR (1) BR0115260A (ru)
CA (1) CA2427467C (ru)
CZ (1) CZ20031515A3 (ru)
DE (1) DE60136490D1 (ru)
EA (1) EA006741B1 (ru)
HU (1) HUP0302352A3 (ru)
IL (1) IL155696A0 (ru)
MX (1) MXPA03004095A (ru)
NO (1) NO20032069L (ru)
NZ (1) NZ525552A (ru)
PL (1) PL363618A1 (ru)
SK (1) SK7092003A3 (ru)
WO (1) WO2002058622A2 (ru)
ZA (1) ZA200303432B (ru)

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US9896441B2 (en) 2014-05-05 2018-02-20 Lycera Corporation Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
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JP6838004B2 (ja) 2015-06-11 2021-03-03 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγのアゴニストとしての使用及び疾患の治療のためのアリールジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物
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KR100869824B1 (ko) 2008-11-21
EA006741B1 (ru) 2006-04-28
MXPA03004095A (es) 2004-09-10
KR20030072352A (ko) 2003-09-13
DE60136490D1 (de) 2008-12-18
NO20032069L (no) 2003-07-02
SK7092003A3 (en) 2004-06-08
EP1355634B8 (en) 2009-03-04
JP2004529086A (ja) 2004-09-24
US7390502B2 (en) 2008-06-24
EP1355634A2 (en) 2003-10-29
US20030215492A1 (en) 2003-11-20
AU2002246510A2 (en) 2002-08-06
NO20032069D0 (no) 2003-05-08
NZ525552A (en) 2005-04-29
EP1355634A4 (en) 2005-07-06
HUP0302352A3 (en) 2007-03-28
AU2002246510B2 (en) 2007-09-20
IL155696A0 (en) 2003-11-23
CA2427467C (en) 2010-01-12
CN1531424A (zh) 2004-09-22
ZA200303432B (en) 2004-08-05
WO2002058622A3 (en) 2003-08-28
HUP0302352A2 (hu) 2003-11-28
ATE413164T1 (de) 2008-11-15
BR0115260A (pt) 2005-08-16
CZ20031515A3 (cs) 2003-09-17
CA2427467A1 (en) 2002-08-01
WO2002058622A2 (en) 2002-08-01
PL363618A1 (en) 2004-11-29
JP4524071B2 (ja) 2010-08-11
EP1355634B1 (en) 2008-11-05
BG107862A (bg) 2004-06-30

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