SK7092003A3 - SN-38 lipid complexes and methods of use - Google Patents
SN-38 lipid complexes and methods of use Download PDFInfo
- Publication number
- SK7092003A3 SK7092003A3 SK709-2003A SK7092003A SK7092003A3 SK 7092003 A3 SK7092003 A3 SK 7092003A3 SK 7092003 A SK7092003 A SK 7092003A SK 7092003 A3 SK7092003 A3 SK 7092003A3
- Authority
- SK
- Slovakia
- Prior art keywords
- composition
- lipid
- compound
- liposomes
- cardiolipin
- Prior art date
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- 238000000034 method Methods 0.000 title claims abstract description 57
- -1 SN-38 lipid Chemical class 0.000 title abstract description 9
- FJHBVJOVLFPMQE-QFIPXVFZSA-N 7-Ethyl-10-Hydroxy-Camptothecin Chemical compound C1=C(O)C=C2C(CC)=C(CN3C(C4=C([C@@](C(=O)OC4)(O)CC)C=C33)=O)C3=NC2=C1 FJHBVJOVLFPMQE-QFIPXVFZSA-N 0.000 claims abstract description 114
- 239000000203 mixture Substances 0.000 claims abstract description 97
- 150000002632 lipids Chemical class 0.000 claims abstract description 69
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 claims abstract description 32
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
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- Dispersion Chemistry (AREA)
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- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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SK (1) | SK7092003A3 (ru) |
WO (1) | WO2002058622A2 (ru) |
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US7138512B2 (en) * | 2002-04-10 | 2006-11-21 | Georgetown University | Gene SHINC-2 and diagnostic and therapeutic uses thereof |
EA200401565A1 (ru) * | 2002-05-24 | 2005-04-28 | Неофарм, Инк. | Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты) |
WO2003099830A2 (en) * | 2002-05-24 | 2003-12-04 | Neopharm, Inc. | Cardiolipin compositions, methods of preparation and use |
WO2003102011A1 (en) * | 2002-05-29 | 2003-12-11 | Neopharm, Inc. | Method for determining oligonucleotide concentration |
WO2004035032A2 (en) * | 2002-08-20 | 2004-04-29 | Neopharm, Inc. | Pharmaceutical formulations of camptothecine derivatives |
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US20050277611A1 (en) * | 2002-10-16 | 2005-12-15 | Neopharm, Inc. | Cationic cardiolipin analoges and its use thereof |
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-
2001
- 2001-11-09 EA EA200300550A patent/EA006741B1/ru not_active IP Right Cessation
- 2001-11-09 AT AT01994079T patent/ATE413164T1/de not_active IP Right Cessation
- 2001-11-09 BR BR0115260-2A patent/BR0115260A/pt not_active IP Right Cessation
- 2001-11-09 WO PCT/US2001/043325 patent/WO2002058622A2/en active IP Right Grant
- 2001-11-09 NZ NZ525552A patent/NZ525552A/en unknown
- 2001-11-09 MX MXPA03004095A patent/MXPA03004095A/es active IP Right Grant
- 2001-11-09 CN CNA018186351A patent/CN1531424A/zh active Pending
- 2001-11-09 KR KR1020037006195A patent/KR100869824B1/ko not_active IP Right Cessation
- 2001-11-09 IL IL15569601A patent/IL155696A0/xx unknown
- 2001-11-09 DE DE60136490T patent/DE60136490D1/de not_active Expired - Lifetime
- 2001-11-09 AU AU2002246510A patent/AU2002246510B2/en not_active Ceased
- 2001-11-09 CZ CZ20031515A patent/CZ20031515A3/cs unknown
- 2001-11-09 PL PL01363618A patent/PL363618A1/xx not_active Application Discontinuation
- 2001-11-09 EP EP01994079A patent/EP1355634B8/en not_active Expired - Lifetime
- 2001-11-09 CA CA002427467A patent/CA2427467C/en not_active Expired - Fee Related
- 2001-11-09 SK SK709-2003A patent/SK7092003A3/sk unknown
- 2001-11-09 JP JP2002558957A patent/JP4524071B2/ja not_active Expired - Fee Related
- 2001-11-09 HU HU0302352A patent/HUP0302352A3/hu unknown
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2003
- 2003-04-28 US US10/424,258 patent/US7390502B2/en not_active Expired - Fee Related
- 2003-05-05 ZA ZA200303432A patent/ZA200303432B/en unknown
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Also Published As
Publication number | Publication date |
---|---|
KR100869824B1 (ko) | 2008-11-21 |
EA006741B1 (ru) | 2006-04-28 |
MXPA03004095A (es) | 2004-09-10 |
KR20030072352A (ko) | 2003-09-13 |
DE60136490D1 (de) | 2008-12-18 |
NO20032069L (no) | 2003-07-02 |
EP1355634B8 (en) | 2009-03-04 |
JP2004529086A (ja) | 2004-09-24 |
US7390502B2 (en) | 2008-06-24 |
EP1355634A2 (en) | 2003-10-29 |
US20030215492A1 (en) | 2003-11-20 |
AU2002246510A2 (en) | 2002-08-06 |
NO20032069D0 (no) | 2003-05-08 |
NZ525552A (en) | 2005-04-29 |
EP1355634A4 (en) | 2005-07-06 |
HUP0302352A3 (en) | 2007-03-28 |
AU2002246510B2 (en) | 2007-09-20 |
IL155696A0 (en) | 2003-11-23 |
CA2427467C (en) | 2010-01-12 |
CN1531424A (zh) | 2004-09-22 |
ZA200303432B (en) | 2004-08-05 |
WO2002058622A3 (en) | 2003-08-28 |
HUP0302352A2 (hu) | 2003-11-28 |
EA200300550A1 (ru) | 2004-06-24 |
ATE413164T1 (de) | 2008-11-15 |
BR0115260A (pt) | 2005-08-16 |
CZ20031515A3 (cs) | 2003-09-17 |
CA2427467A1 (en) | 2002-08-01 |
WO2002058622A2 (en) | 2002-08-01 |
PL363618A1 (en) | 2004-11-29 |
JP4524071B2 (ja) | 2010-08-11 |
EP1355634B1 (en) | 2008-11-05 |
BG107862A (bg) | 2004-06-30 |
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