EA200100841A1 - Оксаминовые кислоты и их производные в качестве лигандов тиреоидных рецепторов - Google Patents

Оксаминовые кислоты и их производные в качестве лигандов тиреоидных рецепторов

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EA200100841A1
EA200100841A1 EA200100841A EA200100841A EA200100841A1 EA 200100841 A1 EA200100841 A1 EA 200100841A1 EA 200100841 A EA200100841 A EA 200100841A EA 200100841 A EA200100841 A EA 200100841A EA 200100841 A1 EA200100841 A1 EA 200100841A1
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Eurasian Patent Office
Prior art keywords
prodrugs
isomers
compounds
oxamine
ligands
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EA200100841A
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English (en)
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EA004229B1 (ru
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Юэн-Чинг Фоиб Чайэнг
Роберт Ли Дау
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Пфайзер Продактс Инк.
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Publication of EA200100841A1 publication Critical patent/EA200100841A1/ru
Publication of EA004229B1 publication Critical patent/EA004229B1/ru

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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Abstract

В настоящем изобретении предложены новые соединения формулы (I), а также их пролекарства, их геометрические и оптические изомеры и фармацевтически приемлемые соли таких соединений, пролекарств и изомеров, где R-Rи W являются такими, как описаны здесь. Предложены также фармацевтические композиции, содержащие такие соединения, пролекарства, изомеры или их фармацевтически приемлемые соли, а также способы, фармацевтические композиции и наборы для лечения ожирения, гиперлипидемии, глаукомы, сердечной аритмии, кожных расстройств, заболевания щитовидной железы, гипотиреоза и родственных расстройств и заболеваний, таких как сахарный диабет, атеросклероз, гипертензия, ишемическая болезнь сердца, гиперхолестеринемия, депрессия и остеопороз.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100841A 1999-03-01 2000-02-21 Оксаминовые кислоты и их производные в качестве лигандов тиреоидных рецепторов EA004229B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12229299P 1999-03-01 1999-03-01
PCT/IB2000/000183 WO2000051971A1 (en) 1999-03-01 2000-02-21 Oxamic acids and derivatives as thyroid receptor ligands

Publications (2)

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EA200100841A1 true EA200100841A1 (ru) 2002-02-28
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ATE272609T1 (de) 2004-08-15
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EP1157001A1 (en) 2001-11-28
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PE20001483A1 (es) 2000-12-29
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CN1345303A (zh) 2002-04-17
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HRP20010633A2 (en) 2002-10-31
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EP1157001B1 (en) 2004-08-04
US6545018B2 (en) 2003-04-08
PA8491501A1 (es) 2001-04-30
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