EA200000526A1 - Комбинация, эффективная для лечения импотенции - Google Patents

Комбинация, эффективная для лечения импотенции

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Publication number
EA200000526A1
EA200000526A1 EA200000526A EA200000526A EA200000526A1 EA 200000526 A1 EA200000526 A1 EA 200000526A1 EA 200000526 A EA200000526 A EA 200000526A EA 200000526 A EA200000526 A EA 200000526A EA 200000526 A1 EA200000526 A1 EA 200000526A1
Authority
EA
Eurasian Patent Office
Prior art keywords
impotence
treatment
combination
effective
compound selected
Prior art date
Application number
EA200000526A
Other languages
English (en)
Inventor
Майкл Грант Вилли
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22090927&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200000526(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200000526A1 publication Critical patent/EA200000526A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

(57) Данное изобретение относится к лечению эректильной дисфункции комбинацией (1) соединения, выбранного из антагонистов α-адренергических рецепторов, и (2) соединения, выбранного из агентов, которые повышают уровни цГМФ. Силденафил или его фармацевтически приемлемая соль предпочтительны в качестве соединений, которые повышают уровни цГМФ-ФДЭ. В данное изобретение включены также композиции и наборы, содержащие такие лечащие импотенцию соединения.Отчет о международном поиске был опубликован 1999.08.26.
EA200000526A 1997-12-16 1998-10-29 Комбинация, эффективная для лечения импотенции EA200000526A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6974197P 1997-12-16 1997-12-16
PCT/IB1998/001723 WO1999030697A2 (en) 1997-12-16 1998-10-29 Combination effective for the treatment of impotence

Publications (1)

Publication Number Publication Date
EA200000526A1 true EA200000526A1 (ru) 2000-12-25

Family

ID=22090927

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000526A EA200000526A1 (ru) 1997-12-16 1998-10-29 Комбинация, эффективная для лечения импотенции

Country Status (37)

Country Link
EP (1) EP1037616B1 (ru)
JP (2) JP2002508315A (ru)
KR (1) KR20010033092A (ru)
CN (1) CN1282248A (ru)
AP (1) AP915A (ru)
AR (1) AR016433A1 (ru)
AT (1) ATE318602T1 (ru)
AU (1) AU759825B2 (ru)
BG (1) BG104528A (ru)
BR (1) BR9813699A (ru)
CA (1) CA2314993A1 (ru)
CO (1) CO4810381A1 (ru)
CZ (1) CZ20002199A3 (ru)
DE (1) DE69833671T2 (ru)
DZ (1) DZ2675A1 (ru)
EA (1) EA200000526A1 (ru)
ES (1) ES2258300T3 (ru)
GT (1) GT199800177A (ru)
HN (1) HN1998000174A (ru)
HR (1) HRP20000407A2 (ru)
HU (1) HUP0100705A3 (ru)
IL (1) IL136515A0 (ru)
IS (1) IS5504A (ru)
MA (1) MA26586A1 (ru)
NO (1) NO20003065L (ru)
NZ (1) NZ504487A (ru)
OA (1) OA11423A (ru)
PA (1) PA8462801A1 (ru)
PE (1) PE20000011A1 (ru)
PL (1) PL341575A1 (ru)
SK (1) SK8782000A3 (ru)
TN (1) TNSN98227A1 (ru)
TR (1) TR200001733T2 (ru)
UY (1) UY25300A1 (ru)
WO (1) WO1999030697A2 (ru)
YU (1) YU33700A (ru)
ZA (1) ZA9811507B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
DE19844162A1 (de) * 1998-09-25 2000-03-30 Udo Dunzendorfer Medikamentenkombinationen zur Therapie der erektilen Dysfunktion
WO2000053148A2 (en) * 1999-03-08 2000-09-14 Merck & Co., Inc. Methods and compositions for treating erectile dysfunction
US7235625B2 (en) * 1999-06-29 2007-06-26 Palatin Technologies, Inc. Multiple agent therapy for sexual dysfunction
EP1200090B1 (en) * 1999-08-03 2013-09-11 ICOS Corporation Pharmaceutical formulation comprising a beta-carboline and its use for treating sexual dysfunction
TWI265925B (en) 1999-10-11 2006-11-11 Pfizer Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
WO2002022127A1 (en) * 2000-09-13 2002-03-21 Isis Innovation Limited Use of phosphodiesterase inhibitors for the treatment of anorectal disorders
ATE303804T1 (de) * 2000-11-17 2005-09-15 Warner Lambert Co Behandlung von sexueller funktionsstörung mit bombesin rezeptor antagonisten
US20030114469A1 (en) * 2001-09-27 2003-06-19 Cohen David Saul Combinations
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
GB0225908D0 (en) * 2002-11-06 2002-12-11 Pfizer Ltd Treatment of female sexual dysfunction
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2451267A1 (en) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
US7291640B2 (en) 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
AP2007004047A0 (en) 2005-01-20 2007-06-30 Pfizer Ltd Substituted triazole derivatives as oxtocin antagonists
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
RU2008122978A (ru) 2005-11-09 2009-12-20 Комбинаторкс, Инкорпорейтед (Us) Способы, композиции и наборы для лечения медицинских состояний
WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
CN101781302B (zh) * 2009-05-31 2013-07-10 段波 一种磷酸二酯酶抑制剂和异黄酮形成的加成物及其应用
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
US20150297601A1 (en) 2012-10-05 2015-10-22 Robert I. Henkin Phosphodiesterase inhibitor treatment
EP3108245B1 (en) 2014-02-18 2020-07-22 Robert I. Henkin Methods and compositions for diagnosing and treating loss and/or distortion of taste or smell

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA878182B (en) * 1986-11-05 1988-05-02 Merrell Dow Pharmaceuticals Inc. Enhancement of prazosin
FR2649613B1 (fr) * 1989-07-11 1991-09-27 Virag Ronald Medicament vaso-actif
US5242391A (en) * 1990-04-25 1993-09-07 Alza Corporation Urethral insert for treatment of erectile dysfunction
ATE113839T1 (de) * 1990-05-31 1994-11-15 Pfizer Arzneimittel gegen impotenz.
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9523752D0 (en) * 1995-11-21 1996-01-24 Pfizer Ltd Pharmaceutical formulations

Also Published As

Publication number Publication date
KR20010033092A (ko) 2001-04-25
ATE318602T1 (de) 2006-03-15
MA26586A1 (fr) 2004-12-20
GT199800177A (es) 2000-05-02
CO4810381A1 (es) 1999-06-30
TR200001733T2 (tr) 2000-11-21
CZ20002199A3 (cs) 2001-10-17
DE69833671T2 (de) 2006-11-30
AU9455898A (en) 1999-07-05
JP2007332156A (ja) 2007-12-27
CN1282248A (zh) 2001-01-31
HUP0100705A2 (hu) 2001-08-28
YU33700A (sh) 2004-05-12
OA11423A (en) 2004-04-21
ES2258300T3 (es) 2006-08-16
AP9801414A0 (en) 1998-12-31
JP2002508315A (ja) 2002-03-19
ZA9811507B (en) 2000-06-19
BG104528A (en) 2001-02-28
PE20000011A1 (es) 2000-01-18
CA2314993A1 (en) 1999-06-24
WO1999030697A3 (en) 1999-08-26
BR9813699A (pt) 2000-10-10
EP1037616A2 (en) 2000-09-27
DZ2675A1 (fr) 2003-03-29
NO20003065D0 (no) 2000-06-15
NZ504487A (en) 2002-11-26
HN1998000174A (es) 1999-01-08
UY25300A1 (es) 2000-12-29
EP1037616B1 (en) 2006-03-01
AU759825B2 (en) 2003-05-01
AP915A (en) 2000-12-18
WO1999030697A2 (en) 1999-06-24
PL341575A1 (en) 2001-04-23
NO20003065L (no) 2000-08-15
IL136515A0 (en) 2001-06-14
SK8782000A3 (en) 2002-03-05
IS5504A (is) 2000-05-19
PA8462801A1 (es) 2000-05-24
DE69833671D1 (de) 2006-04-27
AR016433A1 (es) 2001-07-04
TNSN98227A1 (fr) 2005-03-15
HUP0100705A3 (en) 2001-12-28
HRP20000407A2 (en) 2000-10-31

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