EA199900387A1 - Полипептиды, содержащие домены протеина gax, участвующие в подавлении транскрипции и/или взаимодействующие с другими протеинами, соответствующие нуклеиновые кислоты и их применение - Google Patents

Полипептиды, содержащие домены протеина gax, участвующие в подавлении транскрипции и/или взаимодействующие с другими протеинами, соответствующие нуклеиновые кислоты и их применение

Info

Publication number
EA199900387A1
EA199900387A1 EA199900387A EA199900387A EA199900387A1 EA 199900387 A1 EA199900387 A1 EA 199900387A1 EA 199900387 A EA199900387 A EA 199900387A EA 199900387 A EA199900387 A EA 199900387A EA 199900387 A1 EA199900387 A1 EA 199900387A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gax
domains
transcriptions
interacting
proteins
Prior art date
Application number
EA199900387A
Other languages
English (en)
Other versions
EA003694B1 (ru
Inventor
Дидье Бранеллек
Алан Фурнье
Абдерраим Мафуди
Кристоф Марсиро
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of EA199900387A1 publication Critical patent/EA199900387A1/ru
Publication of EA003694B1 publication Critical patent/EA003694B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/80—Nucleic acid, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Настоящее изобретение относится к полинуклеотидам, включающим домены GAX, участвующие в биологической активности GAX. Это могут быть, в частности, домены, участвующие во взаимодействии GAX с другими молекулами, или домены, участвующие в биологической активности. Изобретение также относится к химерным молекулам, содержащим функциональный домен GAX. Оно также относится к применению GAX для подавления экспрессии генов, а также к применению соединений-ингибиторов взаимодействия GAX с некоторыми клеточными партнерами для изменения активности GAX. Оно также относится к методу просеивания и/или определения клеточных партнеров GAX.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900387A 1996-10-18 1997-10-16 Полипептиды, содержащие домены протеина gax, участвующие в подавлении транскрипции и/или взаимодействующие с другими протеинами, соответствующие нуклеиновые кислоты и их применение EA003694B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9612730A FR2754822B1 (fr) 1996-10-18 1996-10-18 Polypeptides comprenant des domaines de la proteine gax, impliques dans la repression de transcription et/ou interagissant avec d'autres proteines, acides nucleiques correspondants et leurs utilisations
PCT/FR1997/001850 WO1998017686A1 (fr) 1996-10-18 1997-10-16 Polypeptides comprenant des domaines de la proteine gax, impliques dans la repression de transcription et/ou interagissant avec d'autres proteines, acides nucleiques correspondants et leurs utilisations

Publications (2)

Publication Number Publication Date
EA199900387A1 true EA199900387A1 (ru) 1999-10-28
EA003694B1 EA003694B1 (ru) 2003-08-28

Family

ID=9496803

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900387A EA003694B1 (ru) 1996-10-18 1997-10-16 Полипептиды, содержащие домены протеина gax, участвующие в подавлении транскрипции и/или взаимодействующие с другими протеинами, соответствующие нуклеиновые кислоты и их применение

Country Status (22)

Country Link
US (1) US6121005A (ru)
EP (1) EP0941243A1 (ru)
JP (1) JP2001503615A (ru)
KR (1) KR20000049249A (ru)
CN (1) CN1237980A (ru)
AP (1) AP9901510A0 (ru)
AU (1) AU741586B2 (ru)
BG (1) BG63548B1 (ru)
BR (1) BR9711947A (ru)
CA (1) CA2268045A1 (ru)
CZ (1) CZ131899A3 (ru)
EA (1) EA003694B1 (ru)
FR (1) FR2754822B1 (ru)
HU (1) HUP9903956A3 (ru)
IL (1) IL129478A0 (ru)
NO (1) NO991830L (ru)
NZ (1) NZ335283A (ru)
OA (1) OA11034A (ru)
PL (1) PL332874A1 (ru)
SK (1) SK51199A3 (ru)
WO (1) WO1998017686A1 (ru)
ZA (1) ZA979390B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001289652A1 (en) * 2000-06-28 2002-01-08 Aventis Pharma S.A. Compositions and methods for regulating the cell cycle using a ki gene or polypeptide
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US20130059773A1 (en) * 2010-02-24 2013-03-07 Veronique Witko-Sarsat Compounds for the treatment of inflammation and neutropenia

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856121A (en) * 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
US5554181A (en) * 1994-05-04 1996-09-10 Regents Of The University Of Minnesota Stent
GB9422175D0 (en) * 1994-11-03 1994-12-21 Univ Dundee Indentification of the p21 waf1-pcna interaction site and therapeutic applications thereof
FR2732357B1 (fr) * 1995-03-31 1997-04-30 Rhone Poulenc Rorer Sa Vecteurs viraux et utilisation pour le traitement des desordres hyperproliferatifs, notamment de la restenose
FR2740344B1 (fr) * 1995-10-31 1997-11-21 Rhone Poulenc Rorer Sa Application de la proteine gax au traitement de cancers

Also Published As

Publication number Publication date
EA003694B1 (ru) 2003-08-28
WO1998017686A1 (fr) 1998-04-30
BR9711947A (pt) 1999-08-24
BG63548B1 (bg) 2002-04-30
IL129478A0 (en) 2000-02-29
AU741586B2 (en) 2001-12-06
CN1237980A (zh) 1999-12-08
SK51199A3 (en) 2000-04-10
EP0941243A1 (fr) 1999-09-15
ZA979390B (en) 1998-05-12
PL332874A1 (en) 1999-10-25
NO991830L (no) 1999-06-16
JP2001503615A (ja) 2001-03-21
US6121005A (en) 2000-09-19
NZ335283A (en) 2001-02-23
AP9901510A0 (en) 1999-06-30
NO991830D0 (no) 1999-04-16
FR2754822A1 (fr) 1998-04-24
HUP9903956A3 (en) 2002-01-28
BG103342A (en) 2000-05-31
CA2268045A1 (fr) 1998-04-30
HUP9903956A2 (hu) 2000-03-28
KR20000049249A (ko) 2000-07-25
AU4871397A (en) 1998-05-15
OA11034A (fr) 2003-03-06
FR2754822B1 (fr) 1998-11-27
CZ131899A3 (cs) 1999-07-14

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU