EA199700355A1 - Метод диагностики шизофрении - Google Patents

Метод диагностики шизофрении

Info

Publication number
EA199700355A1
EA199700355A1 EA199700355A EA199700355A EA199700355A1 EA 199700355 A1 EA199700355 A1 EA 199700355A1 EA 199700355 A EA199700355 A EA 199700355A EA 199700355 A EA199700355 A EA 199700355A EA 199700355 A1 EA199700355 A1 EA 199700355A1
Authority
EA
Eurasian Patent Office
Prior art keywords
schizophrenia
diagnostic
relates
humthoi
microsatellite
Prior art date
Application number
EA199700355A
Other languages
English (en)
Other versions
EA001037B1 (ru
Inventor
Клодин Лорен
Жак Малле
Роландо Мелони
Original Assignee
Рон-Пуленк Роре С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Роре С.А. filed Critical Рон-Пуленк Роре С.А.
Publication of EA199700355A1 publication Critical patent/EA199700355A1/ru
Publication of EA001037B1 publication Critical patent/EA001037B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Настоящее изобретение относится к методу диагностики шизофрении, основанному на определении ин витро наличия аллеля Ep микросателлита HUMTHOI в гене TH. Изобретение также относится к праймерам, используемым для осуществления этого метода.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199700355A 1995-05-03 1996-04-29 Способ диагностики шизофрении, комплект из двух праймеров для осуществления способа и набор, включающий комплект праймеров EA001037B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9505264A FR2733766B1 (fr) 1995-05-03 1995-05-03 Methode de diagnostic de la schizophrenie
PCT/FR1996/000650 WO1996034980A1 (fr) 1995-05-03 1996-04-29 Methode de diagnostic de la schizophrenie

Publications (2)

Publication Number Publication Date
EA199700355A1 true EA199700355A1 (ru) 1998-08-27
EA001037B1 EA001037B1 (ru) 2000-08-28

Family

ID=9478648

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700355A EA001037B1 (ru) 1995-05-03 1996-04-29 Способ диагностики шизофрении, комплект из двух праймеров для осуществления способа и набор, включающий комплект праймеров

Country Status (29)

Country Link
US (1) US6210879B1 (ru)
EP (1) EP0826068B1 (ru)
JP (1) JPH11504809A (ru)
KR (1) KR19990008221A (ru)
CN (1) CN1125881C (ru)
AP (1) AP770A (ru)
AT (1) ATE193559T1 (ru)
AU (1) AU715264B2 (ru)
BG (1) BG63017B1 (ru)
BR (1) BR9608432A (ru)
CA (1) CA2217332A1 (ru)
CZ (1) CZ291234B6 (ru)
DE (1) DE69608682T2 (ru)
DK (1) DK0826068T3 (ru)
EA (1) EA001037B1 (ru)
ES (1) ES2148760T3 (ru)
FR (1) FR2733766B1 (ru)
GR (1) GR3033592T3 (ru)
HU (1) HUP9802918A3 (ru)
NO (1) NO974974D0 (ru)
NZ (1) NZ308132A (ru)
OA (1) OA10534A (ru)
PL (1) PL183819B1 (ru)
PT (1) PT826068E (ru)
RO (1) RO116731B1 (ru)
SI (1) SI0826068T1 (ru)
SK (1) SK282119B6 (ru)
UA (1) UA49827C2 (ru)
WO (1) WO1996034980A1 (ru)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566065B1 (en) * 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
US6395524B2 (en) 1996-11-27 2002-05-28 University Of Washington Thermostable polymerases having altered fidelity and method of identifying and using same
AU2001288416A1 (en) 2000-08-24 2002-03-04 University Of Pittsburgh Methods and systems for facilitating the diagnosis and treatment of schizophrenia
US20020106794A1 (en) * 2000-08-30 2002-08-08 Lorraine Iacovitti Tyrosine hydroxylase 5' control elements and uses thereof
US20070072233A1 (en) * 2001-05-01 2007-03-29 Levitt Pat R Methods and systems for facilitating the diagnosis and treatment of schizophrenia
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung
US6764824B2 (en) * 2002-03-21 2004-07-20 Council Of Scientific And Industrial Research Primers for screening schizophrenia and a method thereof
CN100342032C (zh) * 2003-05-19 2007-10-10 张岱 精神分裂症易感基因检测方法及易感基因和用途
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
EP2940153B1 (en) * 2009-09-02 2020-05-13 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
JP6155419B2 (ja) 2010-03-25 2017-07-05 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 検出用の液滴輸送システム
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
WO2012061444A2 (en) 2010-11-01 2012-05-10 Hiddessen Amy L System for forming emulsions
WO2012129187A1 (en) 2011-03-18 2012-09-27 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
CN103717749A (zh) 2011-04-25 2014-04-09 伯乐生命医学产品有限公司 用于核酸分析的方法和组合物
CN107677831A (zh) * 2017-06-28 2018-02-09 深圳市龙岗中心医院 测定用于评估精神分裂症病人的诊断标志物的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861504A (en) * 1991-05-29 1999-01-19 The United States Of America As Represented By The Department Of Health And Human Services Eleven highly informative microsatelite repeat polymorphic DNA markers

Also Published As

Publication number Publication date
CZ346797A3 (cs) 1998-01-14
AU5767896A (en) 1996-11-21
AP770A (en) 1999-10-06
HUP9802918A3 (en) 2001-01-29
BG102016A (en) 1998-11-30
US6210879B1 (en) 2001-04-03
FR2733766A1 (fr) 1996-11-08
PL183819B1 (pl) 2002-07-31
EA001037B1 (ru) 2000-08-28
AP9701126A0 (en) 1997-10-31
FR2733766B1 (fr) 1997-06-06
BR9608432A (pt) 1999-03-02
SI0826068T1 (en) 2000-10-31
CN1125881C (zh) 2003-10-29
SK282119B6 (sk) 2001-11-06
EP0826068B1 (fr) 2000-05-31
DK0826068T3 (da) 2000-08-28
HUP9802918A2 (hu) 1999-03-29
KR19990008221A (ko) 1999-01-25
DE69608682D1 (de) 2000-07-06
PL323178A1 (en) 1998-03-16
JPH11504809A (ja) 1999-05-11
NZ308132A (en) 1999-10-28
ES2148760T3 (es) 2000-10-16
NO974974L (no) 1997-10-28
EP0826068A1 (fr) 1998-03-04
UA49827C2 (ru) 2002-10-15
PT826068E (pt) 2000-12-29
AU715264B2 (en) 2000-01-20
BG63017B1 (bg) 2001-01-31
RO116731B1 (ro) 2001-05-30
CN1183122A (zh) 1998-05-27
WO1996034980A1 (fr) 1996-11-07
SK147997A3 (en) 1998-05-06
ATE193559T1 (de) 2000-06-15
NO974974D0 (no) 1997-10-28
OA10534A (fr) 2002-04-29
CA2217332A1 (fr) 1996-11-07
CZ291234B6 (cs) 2003-01-15
DE69608682T2 (de) 2000-10-26
GR3033592T3 (en) 2000-09-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU