EA039404B1 - Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием - Google Patents

Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием Download PDF

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EA039404B1
EA039404B1 EA201690425A EA201690425A EA039404B1 EA 039404 B1 EA039404 B1 EA 039404B1 EA 201690425 A EA201690425 A EA 201690425A EA 201690425 A EA201690425 A EA 201690425A EA 039404 B1 EA039404 B1 EA 039404B1
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Prior art keywords
cells
virus
ndv
tumor
newcastle disease
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EA201690425A
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English (en)
Russian (ru)
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EA201690425A1 (ru
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Синг Чэнг
Дэниелл Кэрролл
Мэттью Маккурт
Марк Галински
Хон Цзинь
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Медиммун Лимитед
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Publication of EA201690425A1 publication Critical patent/EA201690425A1/ru
Publication of EA039404B1 publication Critical patent/EA039404B1/ru

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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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EA201690425A 2013-09-03 2014-09-02 Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием EA039404B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873039P 2013-09-03 2013-09-03
PCT/EP2014/068619 WO2015032755A1 (en) 2013-09-03 2014-09-02 Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia

Publications (2)

Publication Number Publication Date
EA201690425A1 EA201690425A1 (ru) 2016-08-31
EA039404B1 true EA039404B1 (ru) 2022-01-24

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EA201690425A EA039404B1 (ru) 2013-09-03 2014-09-02 Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием
EA202191926A EA202191926A3 (ru) 2013-09-03 2014-09-02 Композиции, содержащие аттенуированный вирус ньюкаслской болезни, и способы применения для лечения неоплазии

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EA202191926A EA202191926A3 (ru) 2013-09-03 2014-09-02 Композиции, содержащие аттенуированный вирус ньюкаслской болезни, и способы применения для лечения неоплазии

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US (2) US10519426B2 (enExample)
EP (3) EP4101457A1 (enExample)
JP (2) JP6557234B2 (enExample)
KR (2) KR102285894B1 (enExample)
CN (2) CN106163532B (enExample)
AU (2) AU2014317215C1 (enExample)
CA (1) CA2922071C (enExample)
CY (2) CY1121993T1 (enExample)
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EA (2) EA039404B1 (enExample)
ES (2) ES2708755T3 (enExample)
HK (2) HK1231393A1 (enExample)
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PL (2) PL3041490T3 (enExample)
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SI (2) SI3508209T1 (enExample)
SM (2) SMT202200214T1 (enExample)
TR (1) TR201902073T4 (enExample)
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PE20151921A1 (es) 2013-03-14 2015-12-26 Icahn School Med Mount Sinai Virus de la enfermedad de newcastle y usos de los mismos
PL3041490T3 (pl) * 2013-09-03 2019-05-31 Medimmune Ltd Kompozycje zawierające atenuowany wirus choroby Newcastle i sposoby ich stosowania w leczeniu neoplazji
AU2015222685A1 (en) 2014-02-27 2016-09-08 Viralytics Limited Combination method for treatment of cancer
WO2016176510A1 (en) * 2015-04-28 2016-11-03 University Of Georgia Research Foundation, Inc. Piv5-based amplifying virus-like particles
EP3400291B2 (en) 2016-01-08 2024-02-28 Replimune Limited Engineered virus
EP3246410A1 (en) * 2016-05-19 2017-11-22 Klinikum rechts der Isar der Technischen Universität München Vsv/ndv hybrid viruses for oncolytic therapy of cancer
GB201700350D0 (en) 2017-01-09 2017-02-22 Replimune Ltd Altered virus
KR101964610B1 (ko) * 2017-03-13 2019-04-03 대한민국 신규한 종양용해성 바이러스 및 이의 용도
JOP20190256A1 (ar) 2017-05-12 2019-10-28 Icahn School Med Mount Sinai فيروسات داء نيوكاسل واستخداماتها
CN107254450A (zh) * 2017-07-20 2017-10-17 扬州大学 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法
CN108486279A (zh) * 2017-09-21 2018-09-04 山东省农业科学院家禽研究所 一种基于荧光定量pcr技术检测鸽新城疫病毒的方法
EP3552608A1 (en) * 2018-04-09 2019-10-16 Rapo Yerape B.H. Ltd Increased activity of oncoloytic newcastle disease virus
CN112601547A (zh) 2018-06-21 2021-04-02 雷普利穆内有限公司 使用溶瘤病毒的治疗
CA3106170A1 (en) * 2018-07-13 2020-01-16 Icahn School Of Medicine At Mount Sinai Apmv and uses thereof for the treatment of cancer
EP3837277A4 (en) 2018-08-17 2022-05-11 Icahn School of Medicine at Mount Sinai RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION
CN110859968A (zh) * 2019-11-21 2020-03-06 四川安可康生物医药有限公司 激活对肿瘤的系统免疫反应的基因生物药物
US20240245805A1 (en) * 2020-03-20 2024-07-25 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2021229270A1 (es) 2020-05-13 2021-11-18 Laboratorio Avi-Mex, S.A. De C.V. Vacuna recombinante contra covid-19 en vector viral
CN115197949A (zh) * 2021-04-13 2022-10-18 江苏康缘瑞翱生物医药科技有限公司 一种重组新城疫病毒rNDV-OX40L、其基因组、制备方法及其用途
KR20240001198A (ko) * 2021-04-26 2024-01-03 이칸 스쿨 오브 메디슨 엣 마운트 시나이 Apmv hn 및 f 단백질을 발현하는 키메라 뉴캐슬병 바이러스
CA3161532A1 (en) * 2021-06-03 2022-12-03 University Of Guelph Engineered newcastle disease virus vector and uses thereof
CN121263205A (zh) * 2023-02-06 2026-01-02 塞维卡有限责任公司 修饰的piv5疫苗载体:制造方法和用途
WO2025116613A1 (ko) * 2023-11-29 2025-06-05 주식회사 카브 재조합 뉴캣슬병 바이러스 벡터를 포함하는 암 치료용 약제학적 조성물
CN120290572A (zh) * 2025-04-09 2025-07-11 梅尔顿(深圳)生物医药技术有限公司 一种重组新城疫病毒及其制备方法和在抗肿瘤中的应用

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