EA039404B1 - Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием - Google Patents
Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием Download PDFInfo
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- EA039404B1 EA039404B1 EA201690425A EA201690425A EA039404B1 EA 039404 B1 EA039404 B1 EA 039404B1 EA 201690425 A EA201690425 A EA 201690425A EA 201690425 A EA201690425 A EA 201690425A EA 039404 B1 EA039404 B1 EA 039404B1
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| US201361873039P | 2013-09-03 | 2013-09-03 | |
| PCT/EP2014/068619 WO2015032755A1 (en) | 2013-09-03 | 2014-09-02 | Compositions featuring an attenuated newcastle disease virus and methods of use for treating neoplasia |
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| EA201690425A1 EA201690425A1 (ru) | 2016-08-31 |
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| EA201690425A EA039404B1 (ru) | 2013-09-03 | 2014-09-02 | Аттенуированный вирус ньюкаслской болезни (ndv) штамма 73т для лечения неоплазии, способ селективного цитолиза опухолевых клеток и способ индуцирования регресса опухоли с его использованием |
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| EA202191926A EA202191926A3 (ru) | 2013-09-03 | 2014-09-02 | Композиции, содержащие аттенуированный вирус ньюкаслской болезни, и способы применения для лечения неоплазии |
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Families Citing this family (22)
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| EA016217B1 (ru) | 2005-12-02 | 2012-03-30 | Маунт Синай Скул Оф Медсин | Химерные вирусы, представляющие неприродные поверхностные белки, и их применение |
| EP2987856B1 (en) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| WO2014158811A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| CN106163532B (zh) * | 2013-09-03 | 2019-12-31 | 免疫医疗有限公司 | 以减毒的新城疫病毒为特征的组合物和用于治疗瘤形成的使用方法 |
| SG11201607130RA (en) | 2014-02-27 | 2016-09-29 | Viralytics Ltd | Combination method for treatment of cancer |
| CN107847610B (zh) * | 2015-04-28 | 2022-02-01 | 塞维卡有限责任公司 | 基于piv5的扩增病毒样颗粒 |
| CN109312309B (zh) | 2016-01-08 | 2024-04-02 | 雷普利穆内有限公司 | 工程化的病毒 |
| EP3246410A1 (en) * | 2016-05-19 | 2017-11-22 | Klinikum rechts der Isar der Technischen Universität München | Vsv/ndv hybrid viruses for oncolytic therapy of cancer |
| GB201700350D0 (en) | 2017-01-09 | 2017-02-22 | Replimune Ltd | Altered virus |
| KR101964610B1 (ko) * | 2017-03-13 | 2019-04-03 | 대한민국 | 신규한 종양용해성 바이러스 및 이의 용도 |
| JOP20190256A1 (ar) * | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| CN107254450A (zh) * | 2017-07-20 | 2017-10-17 | 扬州大学 | 克服鸡新城疫母源抗体影响的嵌合新城疫病毒疫苗载体候选株及构建方法 |
| CN108486279A (zh) * | 2017-09-21 | 2018-09-04 | 山东省农业科学院家禽研究所 | 一种基于荧光定量pcr技术检测鸽新城疫病毒的方法 |
| EP3552608A1 (en) * | 2018-04-09 | 2019-10-16 | Rapo Yerape B.H. Ltd | Increased activity of oncoloytic newcastle disease virus |
| WO2020014591A1 (en) * | 2018-07-13 | 2020-01-16 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| US12391957B2 (en) | 2018-08-17 | 2025-08-19 | Icahn School Of Medicine At Mount Sinai | Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease |
| CN110859968A (zh) * | 2019-11-21 | 2020-03-06 | 四川安可康生物医药有限公司 | 激活对肿瘤的系统免疫反应的基因生物药物 |
| EP4121453A2 (en) * | 2020-03-20 | 2023-01-25 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| CN115197949A (zh) * | 2021-04-13 | 2022-10-18 | 江苏康缘瑞翱生物医药科技有限公司 | 一种重组新城疫病毒rNDV-OX40L、其基因组、制备方法及其用途 |
| US20220396809A1 (en) * | 2021-06-03 | 2022-12-15 | University Of Guelph | Engineered newcastle disease virus vector and uses thereof |
| KR20250144435A (ko) * | 2023-02-06 | 2025-10-10 | 사이안백 엘엘씨 | 변형된 piv5 백신 벡터: 제조 및 사용 방법 |
| WO2025116613A1 (ko) * | 2023-11-29 | 2025-06-05 | 주식회사 카브 | 재조합 뉴캣슬병 바이러스 벡터를 포함하는 암 치료용 약제학적 조성물 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001020989A1 (en) * | 1999-09-22 | 2001-03-29 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| WO2009095167A1 (en) * | 2008-01-29 | 2009-08-06 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
| WO2009101149A2 (en) * | 2008-02-14 | 2009-08-20 | Bayer Schering Pharma Aktiengesellschaft | Anti-tumour effective paramyxovirus |
| WO2010091262A1 (en) * | 2009-02-05 | 2010-08-12 | Mount Sinai School Of Medicine Of New York University | Chimeric newcastle disease viruses and uses thereof |
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| US7724558B1 (en) * | 1999-03-19 | 2010-05-25 | Nec Corporation | Magnetic signal transmission line |
| KR100801180B1 (ko) * | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
| WO2014158811A1 (en) * | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| CN106163532B (zh) * | 2013-09-03 | 2019-12-31 | 免疫医疗有限公司 | 以减毒的新城疫病毒为特征的组合物和用于治疗瘤形成的使用方法 |
| CN109099045A (zh) * | 2018-10-30 | 2018-12-28 | 浙江斯泰新材料科技股份有限公司 | 防松锁固型螺钉 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001020989A1 (en) * | 1999-09-22 | 2001-03-29 | Mayo Foundation For Medical Education And Research | Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family |
| WO2009095167A1 (en) * | 2008-01-29 | 2009-08-06 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
| WO2009101149A2 (en) * | 2008-02-14 | 2009-08-20 | Bayer Schering Pharma Aktiengesellschaft | Anti-tumour effective paramyxovirus |
| WO2010091262A1 (en) * | 2009-02-05 | 2010-08-12 | Mount Sinai School Of Medicine Of New York University | Chimeric newcastle disease viruses and uses thereof |
Non-Patent Citations (5)
| Title |
|---|
| J. C. F. M. DORTMANS, ROTTIER P. J. M., KOCH G., PEETERS B. P. H.: "Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY ¬ETC.|, vol. 92, no. 2, 1 February 2011 (2011-02-01), pages 336 - 345, XP055155911, ISSN: 00221317, DOI: 10.1099/vir.0.026344-0 * |
| JANKE M, ET AL: "Recombinant Newcastle disease virus (NDV) with inserted gene coding for GM-CSF as a new vector for cancer immunogene therapy.", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 14, no. 23, 1 December 2007 (2007-12-01), GB , pages 1639 - 1649, XP002606261, ISSN: 0969-7128, DOI: 10.1038/SJ.GT.3303026 * |
| JOS CFM DORTMANS;GUUS KOCH;PETER JM ROTTIER;BEN PH PEETERS: "Virulence of newcastle disease virus: what is known so far?", VETERINARY RESEARCH, BIOMED CENTRAL LTD, LONDON, UK, vol. 42, no. 1, 23 December 2011 (2011-12-23), London, UK , pages 122, XP021130364, ISSN: 1297-9716, DOI: 10.1186/1297-9716-42-122 * |
| PHILIPPE FOURNIER, VOLKER SCHIRRMACHER: "Oncolytic Newcastle Disease Virus as Cutting Edge between Tumor and Host", BIOLOGY, vol. 2, no. 3, pages 936 - 975, XP055155919, DOI: 10.3390/biology2030936 * |
| S. SAMAL, S. KUMAR, S. K. KHATTAR: "A single amino acid change, Q114R, in the cleavage-site sequence of Newcastle disease virus fusion protein attenuates viral replication and pathogenicity", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY ¬ETC.|, vol. 92, no. 10, 1 October 2011 (2011-10-01), pages 2333 - 2338, XP055156082, ISSN: 00221317, DOI: 10.1099/vir.0.033399-0 * |
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