EA038180B1 - Бензотиофеновые селективные понижающие регуляторы эстрогеновых рецепторов - Google Patents

Бензотиофеновые селективные понижающие регуляторы эстрогеновых рецепторов Download PDF

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Publication number
EA038180B1
EA038180B1 EA201891376A EA201891376A EA038180B1 EA 038180 B1 EA038180 B1 EA 038180B1 EA 201891376 A EA201891376 A EA 201891376A EA 201891376 A EA201891376 A EA 201891376A EA 038180 B1 EA038180 B1 EA 038180B1
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EA
Eurasian Patent Office
Prior art keywords
cancer
compound
pharmaceutically acceptable
estrogen
compound according
Prior art date
Application number
EA201891376A
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English (en)
Russian (ru)
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EA201891376A1 (ru
Inventor
Грегори Р. Тэтчер
Жуй Сюн
Цзюн Чжао
Дебра A. Тонетти
Original Assignee
Зе Боард Оф Трастис Оф Зе Юниверсити Оф Иллинойс
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Application filed by Зе Боард Оф Трастис Оф Зе Юниверсити Оф Иллинойс filed Critical Зе Боард Оф Трастис Оф Зе Юниверсити Оф Иллинойс
Publication of EA201891376A1 publication Critical patent/EA201891376A1/ru
Publication of EA038180B1 publication Critical patent/EA038180B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
EA201891376A 2015-12-09 2016-12-09 Бензотиофеновые селективные понижающие регуляторы эстрогеновых рецепторов EA038180B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US201662322878P 2016-04-15 2016-04-15
PCT/US2016/066023 WO2017100712A1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators

Publications (2)

Publication Number Publication Date
EA201891376A1 EA201891376A1 (ru) 2019-02-28
EA038180B1 true EA038180B1 (ru) 2021-07-20

Family

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EA201891376A EA038180B1 (ru) 2015-12-09 2016-12-09 Бензотиофеновые селективные понижающие регуляторы эстрогеновых рецепторов

Country Status (26)

Country Link
US (7) US20170166551A1 (https=)
EP (2) EP3386968B1 (https=)
JP (2) JP6920709B2 (https=)
KR (1) KR102785173B1 (https=)
CN (2) CN108699024B (https=)
AU (1) AU2016366680B2 (https=)
BR (1) BR112018011607B1 (https=)
CA (1) CA3008020C (https=)
CY (1) CY1125767T1 (https=)
DK (1) DK3386500T3 (https=)
EA (1) EA038180B1 (https=)
ES (1) ES2935125T3 (https=)
HR (1) HRP20221462T1 (https=)
HU (1) HUE061065T2 (https=)
IL (1) IL259566B (https=)
LT (1) LT3386500T (https=)
MX (2) MX393926B (https=)
NZ (1) NZ743651A (https=)
PL (1) PL3386500T3 (https=)
PT (1) PT3386500T (https=)
RS (1) RS63791B1 (https=)
RU (1) RU2747802C2 (https=)
SI (1) SI3386500T1 (https=)
SM (1) SMT202300018T1 (https=)
WO (2) WO2017100712A1 (https=)
ZA (2) ZA201803422B (https=)

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