EA038071B1 - СОЕДИНЕНИЕ СПИРО[3H-ИНДОЛ-3,2'-ПИРРОЛИДИН]-2(1H)-ОНА И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ MDM2-p53 - Google Patents

СОЕДИНЕНИЕ СПИРО[3H-ИНДОЛ-3,2'-ПИРРОЛИДИН]-2(1H)-ОНА И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ MDM2-p53 Download PDF

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EA038071B1
EA038071B1 EA201790425A EA201790425A EA038071B1 EA 038071 B1 EA038071 B1 EA 038071B1 EA 201790425 A EA201790425 A EA 201790425A EA 201790425 A EA201790425 A EA 201790425A EA 038071 B1 EA038071 B1 EA 038071B1
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chiral
group
compound
compounds
pharmaceutically acceptable
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EA201790425A
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Russian (ru)
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EA201790425A1 (ru
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Юрген Рамхартер
Йоахим Брёкер
Анника Гилле
Андреас Голльнер
Мануэль Хенри
Нина Тёлле
Харальд Вайнштабль
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Бёрингер Ингельхайм Интернациональ Гмбх
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    • C07ORGANIC CHEMISTRY
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    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems
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    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61P37/02Immunomodulators
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    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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EA201790425A 2014-08-21 2015-08-20 СОЕДИНЕНИЕ СПИРО[3H-ИНДОЛ-3,2'-ПИРРОЛИДИН]-2(1H)-ОНА И ЕГО ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ MDM2-p53 EA038071B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14181746 2014-08-21
PCT/EP2015/069174 WO2016026937A1 (en) 2014-08-21 2015-08-20 New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors

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EA201790425A1 EA201790425A1 (ru) 2017-07-31
EA038071B1 true EA038071B1 (ru) 2021-07-01

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CN118613485A (zh) 2021-12-01 2024-09-06 勃林格殷格翰国际有限公司 用于治疗癌症的环状2-氨基-3-氰基噻吩及衍生物
CN118574836A (zh) 2021-12-01 2024-08-30 勃林格殷格翰国际有限公司 用于治疗癌症的环状2-胺基-3-氰基噻吩及衍生物
CN119013272A (zh) 2021-12-01 2024-11-22 勃林格殷格翰国际有限公司 用于治疗癌症的环状2-氨基-3-氰基噻吩及其衍生物
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