EA037797B1 - Состав антитела, пригодный для профилактики и лечения амилоидоза, его варианты и способ его получения - Google Patents
Состав антитела, пригодный для профилактики и лечения амилоидоза, его варианты и способ его получения Download PDFInfo
- Publication number
- EA037797B1 EA037797B1 EA201490850A EA201490850A EA037797B1 EA 037797 B1 EA037797 B1 EA 037797B1 EA 201490850 A EA201490850 A EA 201490850A EA 201490850 A EA201490850 A EA 201490850A EA 037797 B1 EA037797 B1 EA 037797B1
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- Eurasian Patent Office
- Prior art keywords
- antibody
- present
- histidine
- concentration
- polysorbate
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101600733B1 (ko) | 2011-10-28 | 2016-03-09 | 프로테나 바이오사이언시즈 리미티드 | 알파-시누클레인을 인식하는 인간화된 항체 |
| WO2013075740A1 (en) | 2011-11-23 | 2013-05-30 | Sanofi | Antibody purification method |
| EP2682168A1 (en) * | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| ES2905675T3 (es) * | 2013-05-06 | 2022-04-11 | Sanofi Sa | Proceso multietapa continuo para purificar anticuerpos |
| US10513555B2 (en) * | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| WO2017189959A1 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| LT3478713T (lt) | 2016-06-30 | 2022-06-10 | Prothena Biosciences Limited | Kompozicijos, skirtos amiloidozės gydymui |
| WO2018173584A1 (ja) | 2017-03-23 | 2018-09-27 | ソニー株式会社 | ビーム照射装置、および検出機能付きプロジェクタ |
| CN111093692A (zh) | 2017-06-29 | 2020-05-01 | 纽约哥伦比亚大学理事会 | 治疗淀粉样沉积疾病的嵌合抗体 |
| US11382974B2 (en) * | 2017-08-01 | 2022-07-12 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treatment of amyloid deposition diseases |
| US12247060B2 (en) | 2018-01-09 | 2025-03-11 | Marengo Therapeutics, Inc. | Calreticulin binding constructs and engineered T cells for the treatment of diseases |
| SG11202009295YA (en) * | 2018-03-23 | 2020-10-29 | Prothena Biosciences Ltd | Treatment and prophylaxis of amyloidosis |
| EP3546475A1 (en) | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| US12018069B2 (en) | 2018-06-28 | 2024-06-25 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for imaging amyloid deposits |
| CA3105448A1 (en) | 2018-07-03 | 2020-01-09 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| JP2022520572A (ja) | 2019-02-12 | 2022-03-31 | プロシーナ バイオサイエンシーズ リミテッド | 免疫グロブリン軽鎖に対するモノクローナル抗体と、抗体産生細胞および他の免疫細胞上のｃｄ３８細胞膜分子に対するモノクローナル抗体の組み合わせによるａｌアミロイドーシスの処置 |
| CR20210435A (es) | 2019-02-18 | 2021-09-20 | Lilly Co Eli | Formulación de anticuerpos terapéuticos |
| CN119039441A (zh) | 2019-02-21 | 2024-11-29 | 马伦戈治疗公司 | 与nkp30结合的抗体分子及其用途 |
| WO2020172571A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Multifunctional molecules that bind to t cell related cancer cells and uses thereof |
| EP3934689B1 (en) | 2019-03-05 | 2025-04-23 | Prothena Biosciences Limited | An antibody for use in methods of treating al amyloidosis |
| JP2023509708A (ja) | 2020-01-03 | 2023-03-09 | マレンゴ・セラピューティクス，インコーポレーテッド | 抗ｔｃｒ抗体分子およびその使用 |
| EP4601619A1 (en) * | 2022-10-12 | 2025-08-20 | Marengo Therapeutics, Inc. | Multifunctional molecules binding to tcr and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090202432A1 (en) * | 2007-12-28 | 2009-08-13 | Elan Pharmaceuticals, Inc. | Treatment and prophylaxis of amyloidosis |
| US20090252724A1 (en) * | 2005-12-12 | 2009-10-08 | Hansruedi Loetscher | Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region |
| US20110070225A1 (en) * | 2006-11-12 | 2011-03-24 | Pierre Goldbach | Beta antibody parenteral formulation |
Family Cites Families (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE229810T1 (de) | 1985-07-09 | 1987-11-05 | Quadrant Bioresources Ltd., Soulbury, Leighton Buzzard, Bedfordshire | Beschuetzung von proteinen und aehnlichem. |
| CA1329760C (en) | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
| US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
| US5945098A (en) | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| US6165500A (en) | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
| EP0580778B1 (en) | 1991-04-19 | 1999-08-11 | LDS Technologies, Inc. | Convertible microemulsion formulations |
| DE69228006T2 (de) | 1991-09-27 | 1999-08-12 | Board of Regents, the University of Texas System, Austin, Tex. | Parenteral anzuwendende Aminosäuren enthaltende Zubereitungen zur Bekämpfung von Hypotension und verwandten Pathologien |
| US5334380A (en) | 1991-09-27 | 1994-08-02 | Board Of Regents, The University Of Texas System | Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension |
| WO1993013752A1 (en) | 1992-01-21 | 1993-07-22 | Sri International | Improved process for preparing micronized polypeptide drugs |
| IL101007A (en) | 1992-02-18 | 1997-08-14 | Pharmos Ltd | Dry stable compositions prepared by lyophilization |
| CA2130357A1 (en) | 1992-02-18 | 1993-08-19 | Doron Friedman | Dry compositions for preparing submicron emulsions |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| EP0686045B1 (en) | 1993-02-23 | 2000-11-15 | Genentech, Inc. | Excipient stabilization of polypeptides treated with organic solvents |
| US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
| IS1796B (is) | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
| EP0736041B1 (en) | 1993-11-17 | 2006-02-08 | Athena Neurosciences, Inc. | Transparent liquid for encapsulated drug delivery |
| US6051256A (en) | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| ATE333867T1 (de) | 1994-03-18 | 2006-08-15 | Shire Lab Inc | Emulgierte arzneistoffabgabesysteme |
| CN1188171C (zh) | 1994-06-02 | 2005-02-09 | 廓德伦特控股剑桥有限公司 | 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物 |
| US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| SK283026B6 (sk) | 1994-08-04 | 2003-02-04 | Quadrant Holdings Cambridge Limited | Tuhý časticový prostriedok na terapeutické použitie a spôsob jeho prípravy |
| US5593824A (en) | 1994-09-02 | 1997-01-14 | Pharmacia Biotech, Inc. | Biological reagent spheres |
| US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
| US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
| CA2218074C (en) | 1995-04-14 | 2002-10-08 | Mohammed Eljamal | Powdered pharmaceutical formulations having improved dispersibility |
| US6309671B1 (en) | 1995-04-14 | 2001-10-30 | Inhale Therapeutic Systems | Stable glassy state powder formulations |
| US6258341B1 (en) | 1995-04-14 | 2001-07-10 | Inhale Therapeutic Systems, Inc. | Stable glassy state powder formulations |
| BR9609188A (pt) | 1995-06-07 | 1999-05-11 | Quadrant Holdings Cambridge | Métodos para incorporar substâncias de modo estável dentro de matrizes de vidro espumado secas e composições obtidas desse modo |
| ES2434840T3 (es) | 1995-07-27 | 2013-12-17 | Genentech, Inc. | Formulación de proteína liofilizada isotónica estable |
| US6267958B1 (en) * | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| ZA966075B (en) * | 1995-07-27 | 1998-01-19 | Genentech Inc | Protein formulation. |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| USRE38431E1 (en) | 1995-12-01 | 2004-02-17 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| JP2000506165A (ja) | 1996-03-04 | 2000-05-23 | ザ ペン ステイト リサーチ ファウンデーション | 細胞インターナリゼーションを増強するための物質および方法 |
| US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| GB9705588D0 (en) | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
| EP0996423B1 (en) | 1997-04-03 | 2011-06-08 | Elias Hakalehto | A method for producing jelly sweets which contain antibodies |
| US20070059302A1 (en) | 1997-04-07 | 2007-03-15 | Genentech, Inc. | Anti-vegf antibodies |
| US6991790B1 (en) | 1997-06-13 | 2006-01-31 | Genentech, Inc. | Antibody formulation |
| JP3919235B2 (ja) | 1997-06-13 | 2007-05-23 | ジェネンテク，インコーポレイテッド | 抗体製剤 |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| ATE286721T1 (de) | 1997-09-19 | 2005-01-15 | Shire Lab Inc | Feste lösungskügelchen |
| US6913745B1 (en) | 1997-12-02 | 2005-07-05 | Neuralab Limited | Passive immunization of Alzheimer's disease |
| CN100341575C (zh) | 1998-06-26 | 2007-10-10 | 大塚制药株式会社 | 水溶性干燥组合物 |
| US6551613B1 (en) | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
| JP2002526397A (ja) | 1998-10-05 | 2002-08-20 | ザ ペン ステイト リサーチ ファンデーション | レセプター媒介細胞インターナリゼーションを増強するための組成物および方法 |
| PL200941B1 (pl) | 1998-11-13 | 2009-02-27 | Jagotec Ag | Suchy proszkowy preparat inhalacyjny |
| DK1031347T3 (da) | 1999-01-27 | 2002-07-08 | Idea Ag | Transnasal transport/immunisering med meget tilpasselige bærere |
| US7258869B1 (en) | 1999-02-08 | 2007-08-21 | Alza Corporation | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle |
| HUP0200202A3 (en) | 1999-02-08 | 2009-08-28 | Alza Corp | Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles |
| AU3957400A (en) | 1999-04-16 | 2000-11-02 | Novo Nordisk A/S | Dry, mouldable drug formulation |
| EP1173245B1 (en) | 1999-05-03 | 2004-09-01 | Battelle Memorial Institute | Compositions for aerosolization and inhalation |
| ES2254174T3 (es) | 1999-05-07 | 2006-06-16 | Genentech, Inc. | Tratamiento de enfermedades autoinmunes con antagonistas que se unen a marcadores de superficie de linfocitos b. |
| GB9914412D0 (en) | 1999-06-22 | 1999-08-18 | Worrall Eric E | Method for the preservation of viruses,bacteria and biomolecules |
| US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
| ATE293159T1 (de) | 1999-12-14 | 2005-04-15 | Thermo Biostar Inc | Stabilisierendes verdünnungsmittel für polypeptide und antigene |
| US7919113B2 (en) | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
| US6465425B1 (en) | 2000-02-10 | 2002-10-15 | Alkermes Controlled Therapeutics, Inc. | Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins |
| US6653062B1 (en) | 2000-07-26 | 2003-11-25 | Wisconsin Alumni Research Foundation | Preservation and storage medium for biological materials |
| US7141236B2 (en) | 2000-07-28 | 2006-11-28 | Nektar Therapeutics | Methods and compositions for delivering macromolecules to or via the respiratory tract |
| WO2002030463A2 (en) | 2000-10-12 | 2002-04-18 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
| CA2431600C (en) | 2000-12-12 | 2012-04-17 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| JP4460892B2 (ja) | 2001-06-21 | 2010-05-12 | ジェネンテック インコーポレイテッド | 徐放性組成物 |
| EP2270052B8 (en) | 2001-06-26 | 2018-05-02 | Amgen Inc. | Antibodies to OPGL |
| US6646394B2 (en) * | 2001-07-09 | 2003-11-11 | Nissan Motor Co., Ltd. | Control device for plurality of rotating electrical machines |
| JP4317010B2 (ja) | 2001-07-25 | 2009-08-19 | ピーディーエル バイオファーマ，インコーポレイティド | ＩｇＧ抗体の安定な凍結乾燥医薬製剤 |
| US20040023338A1 (en) * | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-4 mutein proteins, antibodies, compositions, methods and uses |
| ES2392073T3 (es) | 2001-11-08 | 2012-12-04 | Abbott Biotherapeutics Corp. | Formulación farmacéutica líquida estable de anticuerpos IGG |
| DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| WO2003068259A1 (fr) | 2002-02-14 | 2003-08-21 | Chugai Seiyaku Kabushiki Kaisha | Produits pharmaceutiques en solution contenant des anticorps |
| CA2476934C (en) | 2002-02-27 | 2009-06-16 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine |
| US6982080B2 (en) | 2002-03-15 | 2006-01-03 | Wyeth | Hydroxyethyl starch—containing polypeptide compositions |
| EP2591771A1 (en) | 2002-04-11 | 2013-05-15 | MedImmune, LLC | Preservation of bioactive materials by freeze dried foam |
| JP2006512102A (ja) | 2002-04-11 | 2006-04-13 | メディミューン・ヴァクシンズ・インコーポレーテッド | 噴霧乾燥による生物活性材料の防腐 |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| US20040120956A1 (en) * | 2002-06-27 | 2004-06-24 | Song Xiao-Yu R. | CNGH0004 polypeptides, antibodies, compositions, methods and uses |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| JP2006504801A (ja) | 2002-11-01 | 2006-02-09 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥方法 |
| JP4776233B2 (ja) | 2002-11-12 | 2011-09-21 | エラン ファーマ インターナショナル，リミティド | 摩損しにくくかつプルランを含む速崩壊性固形製剤 |
| TWI335821B (en) | 2002-12-16 | 2011-01-11 | Genentech Inc | Immunoglobulin variants and uses thereof |
| EP1581639A4 (en) | 2002-12-17 | 2006-03-08 | Medimmune Vaccines Inc | HIGH PRESSURE PULVISATION OF BIOACTIVE MATERIALS |
| PT1610820E (pt) * | 2003-04-04 | 2010-12-16 | Novartis Ag | Formulações de elevada concentração de anticorpos e proteínas |
| NZ543498A (en) | 2003-05-14 | 2007-06-29 | Immunogen Inc | A conjugate comprising an antibody chemically coupled to a maytansinoid |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| WO2005044306A2 (en) | 2003-11-04 | 2005-05-19 | Chiron Corporation | Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| DE10355251A1 (de) | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
| SI21639A (sl) | 2003-12-23 | 2005-06-30 | LEK farmacevtska dru�ba d.d. | Farmacevtski pripravek, ki vsebuje nemicelarne sulfobetaine |
| NZ549893A (en) | 2004-03-24 | 2010-05-28 | Facet Biotech Corp | Use of anti-alpha5beta1 antibodiesin a stabilising solution to inhibit cancer cell proliferation |
| US8043631B2 (en) | 2004-04-02 | 2011-10-25 | Au Jessie L S | Tumor targeting drug-loaded particles |
| WO2005117967A2 (en) | 2004-04-12 | 2005-12-15 | Medimmune, Inc. | Anti-il-9 antibody formulations and uses thereof |
| GB0409795D0 (en) | 2004-04-30 | 2004-06-09 | Glaxosmithkline Biolog Sa | Drying method |
| AU2005259221B2 (en) | 2004-07-01 | 2011-02-10 | Innate Pharma | Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| EP2465872A3 (en) * | 2004-10-25 | 2012-12-19 | Merck Sharp & Dohme Corporation | Anti-ADDL antibodies and uses thereof |
| CA2586074C (en) | 2004-11-09 | 2013-07-23 | Novagali Pharma Sa | Ophthalmic oil-in-water type emulsion with stable positive zeta potential |
| US20060124266A1 (en) * | 2004-11-23 | 2006-06-15 | Novozymes North America, Inc. | Use of cyclodextrins for reducing deposits during paper production |
| US7897585B1 (en) | 2005-01-04 | 2011-03-01 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US8048453B1 (en) | 2005-01-04 | 2011-11-01 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles for protein drug delivery |
| US7910086B1 (en) | 2005-01-04 | 2011-03-22 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7919072B1 (en) | 2005-01-04 | 2011-04-05 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7993625B1 (en) | 2005-01-04 | 2011-08-09 | Gp Medical, Inc. | Pharmaceutical composition of nanoparticles |
| US7541046B1 (en) | 2005-01-04 | 2009-06-02 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| US7879313B1 (en) | 2005-01-04 | 2011-02-01 | Gp Medical, Inc. | Nanoparticles for protein drug delivery |
| GT200600031A (es) | 2005-01-28 | 2006-08-29 | Formulacion anticuerpo anti a beta | |
| TW200640492A (en) | 2005-02-21 | 2006-12-01 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
| US7785595B2 (en) | 2005-04-18 | 2010-08-31 | Yeda Research And Development Company Limited | Stabilized anti-hepatitis B (HBV) antibody formulations |
| AU2006240056B2 (en) | 2005-04-22 | 2012-02-16 | Eli Lilly And Company | TGF Beta 1 specific antibodies |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| BRPI0611765B1 (pt) | 2005-06-07 | 2022-09-27 | Esbatech Ag | Anticorpo ou fragmento de anticorpo estável e solúvel que se liga especificamente ao tnf-alfa seus usos e composição diagnóstica ou terapêutica |
| CN103145839A (zh) | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| CA2612937C (en) | 2005-07-22 | 2014-05-06 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
| AU2006330858A1 (en) | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
| HRP20110203T4 (hr) | 2006-03-23 | 2014-05-09 | Bioarctic Neuroscience Ab | Poboljšana protutijela selektivna za protofibrile i njihova primjena |
| DE102006030164A1 (de) | 2006-06-29 | 2008-01-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Inhalative Pulver |
| MX2009000476A (es) * | 2006-07-14 | 2009-01-28 | Ac Immune Sa | Anticuerpo humanizado contra beta amiloide. |
| EP2094247B1 (en) | 2006-10-20 | 2022-06-29 | Amgen Inc. | Stable polypeptide formulations |
| GB0621707D0 (en) | 2006-10-31 | 2006-12-13 | Univ London Pharmacy | Formulations for delivery via pressurised metered dose inhalers |
| MX2009005414A (es) | 2006-12-05 | 2009-06-01 | Crucell Holland Bv | Formulaciones liquidas de anticuerpo antirrabico. |
| US7883664B2 (en) | 2007-06-27 | 2011-02-08 | University Of North Carolina At Charlotte | Microwave drying process for vitrification of biologics |
| US8268354B2 (en) | 2007-11-07 | 2012-09-18 | Aridis Pharmaceuticals | Sonic low pressure spray drying |
| EP2234600B1 (en) | 2007-12-21 | 2014-08-20 | F. Hoffmann-La Roche AG | Antibody formulation |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| WO2009158412A2 (en) | 2008-06-25 | 2009-12-30 | Endo Pharmaceuticals Solutions Inc. | Sustained delivery of exenatide and other polypeptides |
| WO2009158432A2 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| US8187601B2 (en) | 2008-07-01 | 2012-05-29 | Aveo Pharmaceuticals, Inc. | Fibroblast growth factor receptor 3 (FGFR3) binding proteins |
| MX2011002159A (es) | 2008-08-27 | 2011-03-29 | Schering Corp | Formulaciones liofilizadas de anticuerpos anti-interleucina-23p19 construidos por ingenieria. |
| CN102159194A (zh) | 2008-09-19 | 2011-08-17 | 霍夫曼-拉罗奇有限公司 | 新抗体制剂 |
| WO2010059787A1 (en) * | 2008-11-20 | 2010-05-27 | Genentech, Inc. | Therapeutic protein formulations |
| CN201401081Y (zh) | 2009-03-26 | 2010-02-10 | 徐谦 | 一种两折型合页 |
| CN201553504U (zh) * | 2009-10-30 | 2010-08-18 | 浙江浦江缆索有限公司 | 一种悬索拉索成圈用120t成圈机 |
| RU2684703C2 (ru) * | 2014-03-14 | 2019-04-11 | Иннейт Фарма | Гуманизированные антитела с повышенной стабильностью |
-
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- 2012-10-25 AU AU2012328739A patent/AU2012328739B2/en active Active
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090252724A1 (en) * | 2005-12-12 | 2009-10-08 | Hansruedi Loetscher | Antibodies Against Amyloid Beta 4 With Glycosylated in the Variable Region |
| US20110070225A1 (en) * | 2006-11-12 | 2011-03-24 | Pierre Goldbach | Beta antibody parenteral formulation |
| US20090202432A1 (en) * | 2007-12-28 | 2009-08-13 | Elan Pharmaceuticals, Inc. | Treatment and prophylaxis of amyloidosis |
| US20110038790A1 (en) * | 2007-12-28 | 2011-02-17 | Schenk Dale B | Treatment and prophylaxis of amyloidosis |
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