EA037654B1 - Анти-cd47-антитела и их применения - Google Patents
Анти-cd47-антитела и их применения Download PDFInfo
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- EA037654B1 EA037654B1 EA201791485A EA201791485A EA037654B1 EA 037654 B1 EA037654 B1 EA 037654B1 EA 201791485 A EA201791485 A EA 201791485A EA 201791485 A EA201791485 A EA 201791485A EA 037654 B1 EA037654 B1 EA 037654B1
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- antibody
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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- C07K—PEPTIDES
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201462098291P | 2014-12-30 | 2014-12-30 | |
| PCT/US2015/067642 WO2016109415A1 (en) | 2014-12-30 | 2015-12-28 | Anti-cd47 antibodies and uses thereof |
Publications (2)
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| EA201791485A1 EA201791485A1 (ru) | 2018-02-28 |
| EA037654B1 true EA037654B1 (ru) | 2021-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791485A EA037654B1 (ru) | 2014-12-30 | 2015-12-28 | Анти-cd47-антитела и их применения |
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|---|---|
| US (2) | US10870699B2 (enExample) |
| EP (1) | EP3240569A4 (enExample) |
| JP (2) | JP6850255B2 (enExample) |
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| WO (1) | WO2016109415A1 (enExample) |
| ZA (1) | ZA201704467B (enExample) |
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| EP3240569A4 (en) | 2014-12-30 | 2018-05-30 | Celgene Corporation | Anti-cd47 antibodies and uses thereof |
| WO2016177802A1 (en) * | 2015-05-04 | 2016-11-10 | Pieris Pharmaceuticals Gmbh | Anti-cancer fusion polypeptide |
| TW201811824A (zh) * | 2016-07-06 | 2018-04-01 | 美商西建公司 | 具有低免疫原性之抗體及其用途 |
| WO2018059502A1 (en) | 2016-09-29 | 2018-04-05 | Beijing Hanmi Pharmaceutical Co., Ltd. | Heterodimeric immunoglobulin constructs and preparation methods thereof |
| KR20220104298A (ko) | 2016-10-20 | 2022-07-26 | 아이-맵 바이오파마 유에스 리미티드 | 새로운 cd47 단일클론 항체 및 그 용도 |
| WO2018081898A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
| US11352425B2 (en) * | 2016-11-08 | 2022-06-07 | Absos, Llc | Anti-CD47 antibodies |
| CA3043652A1 (en) | 2016-11-18 | 2018-05-24 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-pd-1/anti-her2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same |
| US11267885B2 (en) | 2017-01-26 | 2022-03-08 | Zlip Holding Limited | CD47 antigen binding unit and uses thereof |
| WO2018152033A1 (en) * | 2017-02-14 | 2018-08-23 | Promab Biotechnologies, Inc. | Cd47-car-t cells |
| WO2018183182A1 (en) * | 2017-03-27 | 2018-10-04 | Celgene Corporation | Methods and compositions for reduction of immunogenicity |
| CN110770345A (zh) | 2017-04-14 | 2020-02-07 | 托尔奈公司 | 免疫调节多核苷酸、抗体缀合物及其使用方法 |
| AU2018312222B2 (en) * | 2017-08-02 | 2024-11-21 | Phanes Therapeutics, Inc. | Anti-CD47 antibodies and uses thereof |
| CN111212852A (zh) | 2017-08-18 | 2020-05-29 | 超人肆有限公司 | 结合剂 |
| WO2019091473A1 (en) * | 2017-11-10 | 2019-05-16 | I-Mab Biopharma Co., Ltd. | Fusion proteins containing cd47 antibodies and cytokines |
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| BR112020011295A2 (pt) * | 2017-12-04 | 2020-11-24 | Beijing Hanmi Pharmaceutical Co., Ltd. | anticorpo biespecífico anti-pd-l1/anti-cd47 com estrutura semelhante ao anticorpo natural e em forma de heterodímero e preparação do mesmo |
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| CN107530421B (zh) | 2021-07-20 |
| BR112017014258A2 (pt) | 2018-03-06 |
| SG11201705310TA (en) | 2017-07-28 |
| US10870699B2 (en) | 2020-12-22 |
| JP6850255B2 (ja) | 2021-03-31 |
| KR20170100652A (ko) | 2017-09-04 |
| EP3240569A4 (en) | 2018-05-30 |
| WO2016109415A1 (en) | 2016-07-07 |
| SG10202007176TA (en) | 2020-08-28 |
| US20170369572A1 (en) | 2017-12-28 |
| MX391051B (es) | 2025-03-21 |
| CL2017001736A1 (es) | 2018-03-16 |
| CA2972604A1 (en) | 2016-07-07 |
| CO2017007673A2 (es) | 2018-01-05 |
| CA2972604C (en) | 2023-07-04 |
| JP2018506964A (ja) | 2018-03-15 |
| CN107530421A (zh) | 2018-01-02 |
| MX2017008819A (es) | 2018-03-14 |
| EP3240569A1 (en) | 2017-11-08 |
| ECSP17041865A (es) | 2017-08-31 |
| US20210054070A1 (en) | 2021-02-25 |
| ZA201704467B (en) | 2019-09-25 |
| EA201791485A1 (ru) | 2018-02-28 |
| HK1245154A1 (zh) | 2018-08-24 |
| AU2015374301B2 (en) | 2021-02-11 |
| AU2015374301A1 (en) | 2017-07-20 |
| KR102489471B1 (ko) | 2023-01-18 |
| US11787860B2 (en) | 2023-10-17 |
| JP2021048858A (ja) | 2021-04-01 |
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