EA035262B1 - Противораковые агенты и их получение - Google Patents
Противораковые агенты и их получение Download PDFInfo
- Publication number
- EA035262B1 EA035262B1 EA201691010A EA201691010A EA035262B1 EA 035262 B1 EA035262 B1 EA 035262B1 EA 201691010 A EA201691010 A EA 201691010A EA 201691010 A EA201691010 A EA 201691010A EA 035262 B1 EA035262 B1 EA 035262B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- cancer
- pharmaceutically acceptable
- compounds
- compound
- present
- Prior art date
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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- VFJYIHQDILEQNR-UHFFFAOYSA-M trimethylsulfanium;iodide Chemical compound [I-].C[S+](C)C VFJYIHQDILEQNR-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Peptides Or Proteins (AREA)
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| US201361906133P | 2013-11-19 | 2013-11-19 | |
| PCT/US2014/066458 WO2015077370A1 (en) | 2013-11-19 | 2014-11-19 | Anti-cancer agents and preparation thereof |
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| EA201691010A1 EA201691010A1 (ru) | 2016-11-30 |
| EA035262B1 true EA035262B1 (ru) | 2020-05-21 |
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| EP (1) | EP3071563B1 (OSRAM) |
| JP (2) | JP6937578B2 (OSRAM) |
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| PH (2) | PH12021551085A1 (OSRAM) |
| PT (1) | PT3071563T (OSRAM) |
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| EA035262B1 (ru) | 2013-11-19 | 2020-05-21 | Пюрдью Рисёрч Фаундейшн | Противораковые агенты и их получение |
| JP2019524650A (ja) * | 2016-06-08 | 2019-09-05 | ウィリアム マーシュ ライス ユニバーシティＷｉｌｌｉａｍ Ｍａｒｓｈ Ｒｉｃｅ Ｕｎｉｖｅｒｓｉｔｙ | タイランスタチンａの誘導体、それについての治療方法および合成方法 |
| CA3037883A1 (en) | 2016-09-23 | 2018-03-29 | Purdue Research Foundation | Anti-cancer agents and preparation thereof |
| CN111788208B (zh) | 2017-09-20 | 2023-11-24 | Ph制药有限公司 | 泰兰他汀类似物 |
| CN109020876A (zh) * | 2018-09-21 | 2018-12-18 | 大连理工大学 | 一种新型6-羟基-2h-二氢吡啶-3-酮的制备方法 |
| JP2023521135A (ja) * | 2020-04-09 | 2023-05-23 | ブリストル－マイヤーズ スクイブ カンパニー | メアヤマイシン類似体および使用方法 |
| CN113563361B (zh) * | 2021-08-17 | 2022-05-20 | 浙江珲达生物科技有限公司 | 一种从伯克霍尔德菌发酵液提取fr901464的方法 |
Citations (2)
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| US20110207604A1 (en) * | 2010-02-25 | 2011-08-25 | Marrone Bio Innovations | Isolated bacterial strain of the genus burkholderia and pesticidal metabolites therefrom |
| US8309599B2 (en) * | 2006-09-08 | 2012-11-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Synthesis of FR901464 and analogs with antitumor activity |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901464A (fr) | 1943-01-23 | 1945-07-27 | Boehringer & Soehne Gmbh | Procédé d'obtention de vanilline |
| HUE025507T2 (en) | 2008-03-18 | 2016-02-29 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| IN2014MN00242A (OSRAM) * | 2011-08-27 | 2015-09-25 | Marrone Bio Innovations Inc | |
| RU2618523C2 (ru) * | 2012-11-05 | 2017-05-04 | Пфайзер Инк. | Аналоги сплицеостатина |
| EA035262B1 (ru) | 2013-11-19 | 2020-05-21 | Пюрдью Рисёрч Фаундейшн | Противораковые агенты и их получение |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8309599B2 (en) * | 2006-09-08 | 2012-11-13 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Synthesis of FR901464 and analogs with antitumor activity |
| US20110207604A1 (en) * | 2010-02-25 | 2011-08-25 | Marrone Bio Innovations | Isolated bacterial strain of the genus burkholderia and pesticidal metabolites therefrom |
Non-Patent Citations (4)
| Title |
|---|
| Ghosh et al.: "Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome", Org. Lett., 2013, 15 (19), pp. 508875091, Publication Date (Web): September 19, 2013 * |
| Horigome et al.: "A synthesis of FR901464", Tetrahedron Letters 42 (2001), 8207-8210 * |
| Koide et al.: "Total Syntheses of FR901464", Review Article, 2007, https:// www.jstage.jst.go.jp/article/yukigoseikyokaishi1943/65/2/65_2_119/_pdf * |
| Motoyoshi et al.: Total synthesis of FR901464: second generation', Tetrahedron 62 (2006), 1378-1389 * |
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