EA033829B1 - Комбинированная терапия для лечения устойчивых бактериальных инфекций - Google Patents
Комбинированная терапия для лечения устойчивых бактериальных инфекций Download PDFInfo
- Publication number
- EA033829B1 EA033829B1 EA201791069A EA201791069A EA033829B1 EA 033829 B1 EA033829 B1 EA 033829B1 EA 201791069 A EA201791069 A EA 201791069A EA 201791069 A EA201791069 A EA 201791069A EA 033829 B1 EA033829 B1 EA 033829B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- sulbactam
- compound
- imipenem
- Prior art date
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462080667P | 2014-11-17 | 2014-11-17 | |
| PCT/US2015/061076 WO2016081452A1 (en) | 2014-11-17 | 2015-11-17 | Combination therapy for treatment of resistant bacterial infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201791069A1 EA201791069A1 (ru) | 2017-11-30 |
| EA033829B1 true EA033829B1 (ru) | 2019-11-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201791069A EA033829B1 (ru) | 2014-11-17 | 2015-11-17 | Комбинированная терапия для лечения устойчивых бактериальных инфекций |
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| CN (1) | CN107108624B (OSRAM) |
| AU (1) | AU2015350128B2 (OSRAM) |
| BR (1) | BR112017010132B1 (OSRAM) |
| CA (1) | CA2966632C (OSRAM) |
| CY (1) | CY1121384T1 (OSRAM) |
| DK (1) | DK3221313T3 (OSRAM) |
| EA (1) | EA033829B1 (OSRAM) |
| ES (1) | ES2717776T3 (OSRAM) |
| HK (1) | HK1244798B (OSRAM) |
| HR (1) | HRP20190580T1 (OSRAM) |
| HU (1) | HUE044061T2 (OSRAM) |
| IL (1) | IL251979B (OSRAM) |
| LT (1) | LT3221313T (OSRAM) |
| ME (1) | ME03357B (OSRAM) |
| MX (1) | MX2017006383A (OSRAM) |
| MY (1) | MY196240A (OSRAM) |
| PH (1) | PH12017500852B1 (OSRAM) |
| PL (1) | PL3221313T3 (OSRAM) |
| PT (1) | PT3221313T (OSRAM) |
| RS (1) | RS58429B1 (OSRAM) |
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| SI3221313T1 (sl) | 2014-11-17 | 2019-04-30 | Entasis Therapeutics Limited | Kombinacijska terapija za zdravljenje okužb z rezistentnimi bakterijami |
| WO2017203266A1 (en) * | 2016-05-25 | 2017-11-30 | Entasis Therapeutics Limited | Combination therapy for treatment of resistant bacterial infections |
| SMT202200397T1 (it) * | 2016-09-16 | 2022-11-18 | Entasis Therapeutics Ltd | Composti inibitori di beta-lattamasi |
| EP3301094A1 (en) * | 2016-09-30 | 2018-04-04 | Mutabilis | Heterocyclic compounds and their use in preventing or treating bacterial infections |
| EA037916B1 (ru) * | 2017-02-08 | 2021-06-07 | Энтасис Терапеутикс Лимитед | Соединения-ингибиторы бета-лактамаз |
| CN110709081B (zh) | 2017-05-08 | 2023-09-22 | 恩塔西斯治疗公司 | 用于治疗细菌感染的化合物及方法 |
| CN109422765B (zh) * | 2017-09-05 | 2020-08-28 | 香港理工大学深圳研究院 | C类β-内酰胺酶抑制剂及其制备方法和应用 |
| US11905286B2 (en) | 2018-08-09 | 2024-02-20 | Antabio Sas | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| EP3833665B1 (en) | 2018-08-09 | 2023-07-19 | Antabio SAS | Diazabicyclooctanones as inhibitors of serine beta-lactamases |
| CN111658642A (zh) * | 2019-03-05 | 2020-09-15 | 广州新创忆药物临床研究有限公司 | 一种治疗耐碳青霉烯类抗生素鲍曼不动杆菌感染的组合物 |
| TWI715397B (zh) * | 2019-12-31 | 2021-01-01 | 高雄榮民總醫院 | 根據領先標準將同儕數據繪製為圖表的方法、電腦程式產品及電腦可讀取媒體 |
| EP4125905B1 (en) * | 2020-04-02 | 2024-12-25 | GlaxoSmithKline Intellectual Property Development Limited | Regimen for treating a neisseria gonorrhoeae infection with gepotidacin |
| CN117062598A (zh) * | 2021-01-20 | 2023-11-14 | 恩塔西斯治疗有限公司 | 固定剂量抗生素组合物 |
| WO2023206580A1 (en) * | 2022-04-29 | 2023-11-02 | Entasis Therapeutics Limited | Durlobactam crystalline forms |
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