EA032117B1 - Применение антитела di17e6 к интегрину альфа-v при производстве лекарственного средства и лечении рака простаты, способ лечения устойчивого к кастрации рака простаты (crpc), способ снижения уровня пса, способ снижения боли, проявляющейся при раке простаты - Google Patents
Применение антитела di17e6 к интегрину альфа-v при производстве лекарственного средства и лечении рака простаты, способ лечения устойчивого к кастрации рака простаты (crpc), способ снижения уровня пса, способ снижения боли, проявляющейся при раке простаты Download PDFInfo
- Publication number
- EA032117B1 EA032117B1 EA201391147A EA201391147A EA032117B1 EA 032117 B1 EA032117 B1 EA 032117B1 EA 201391147 A EA201391147 A EA 201391147A EA 201391147 A EA201391147 A EA 201391147A EA 032117 B1 EA032117 B1 EA 032117B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- όι17ε6
- prostate cancer
- treatment
- antibody
- antibodies
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Cell Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11001135 | 2011-02-11 | ||
| PCT/EP2012/000548 WO2012107211A1 (en) | 2011-02-11 | 2012-02-07 | Anti-alpha-v integrin antibody for the treatment of prostate cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201391147A1 EA201391147A1 (ru) | 2014-01-30 |
| EA032117B1 true EA032117B1 (ru) | 2019-04-30 |
Family
ID=45569571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201391147A EA032117B1 (ru) | 2011-02-11 | 2012-02-07 | Применение антитела di17e6 к интегрину альфа-v при производстве лекарственного средства и лечении рака простаты, способ лечения устойчивого к кастрации рака простаты (crpc), способ снижения уровня пса, способ снижения боли, проявляющейся при раке простаты |
Country Status (23)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| CA2961426C (en) * | 2014-09-17 | 2024-01-09 | Merck Patent Gmbh | A method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases |
| KR20170052690A (ko) | 2014-09-17 | 2017-05-12 | 메르크 파텐트 게엠베하 | 고형암 및/또는 이의 전이 치료 방법, 그에 따른 약제, 및 고형암 및/또는 이의 전이 치료의 임상 결과 예측 방법 |
| JP7034914B2 (ja) | 2015-11-23 | 2022-03-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 線維症および／または線維性疾患の治療のための抗α－ｖインテグリン抗体 |
| MX2018006269A (es) * | 2015-11-23 | 2018-09-05 | Merck Patent Gmbh | Anticuerpo anti-alfa-v-integrina para el tratamiento de fibrosis y/o trastornos fibroticos. |
| WO2024137442A1 (en) | 2022-12-21 | 2024-06-27 | Gilead Sciences, Inc. | Combination therapy for treating cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
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| CZ283717B6 (cs) | 1991-03-06 | 1998-06-17 | MERCK Patent Gesellschaft mit beschränkter Haftung | Chimérická monoklonální protilátka, expresní vektory a farmaceutický prostředek |
| US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
| ATE244306T1 (de) | 1994-12-20 | 2003-07-15 | Merck Patent Gmbh | Monoklonaler antikörper gegen das alpha-v- integrin |
| DE19534177A1 (de) | 1995-09-15 | 1997-03-20 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| CA2290485C (en) | 1997-05-21 | 2008-08-05 | Biovation Limited | Method for the production of non-immunogenic proteins |
| DE19842415A1 (de) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung |
| ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| US7163681B2 (en) * | 2000-08-07 | 2007-01-16 | Centocor, Inc. | Anti-integrin antibodies, compositions, methods and uses |
| MXPA03007316A (es) | 2001-02-19 | 2003-12-04 | Merck Patent Gmbh | Metodo para la identificacion de epitopes de celulas t y el uso para la preparacion de moleculas con inmunogenicidad reducida. |
| DE10163459A1 (de) | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
| CA2507099C (en) | 2002-11-26 | 2013-09-24 | Protein Design Labs, Inc. | Chimeric and humanized antibodies to .alpha.5.beta.1 integrin that modulate angiogenesis |
| US8147832B2 (en) | 2003-08-14 | 2012-04-03 | Merck Patent Gmbh | CD20-binding polypeptide compositions and methods |
| US20070172475A1 (en) | 2004-02-12 | 2007-07-26 | Susanne Matheus | Highly concentrated, liquid formulations of anti-egfr antibodies |
| KR20060002667A (ko) | 2004-07-03 | 2006-01-09 | 삼성전자주식회사 | 디스크 댐퍼와 디스크 프로텍터를 구비한 하드 디스크드라이브 |
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| JP2009521912A (ja) | 2005-12-30 | 2009-06-11 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低減された免疫原性を有する抗ｃｄ１９抗体 |
| WO2007084670A2 (en) | 2006-01-18 | 2007-07-26 | Merck Patent Gmbh | Specific therapy using integrin ligands for treating cancer |
| WO2008008435A2 (en) | 2006-07-14 | 2008-01-17 | Rutgers, The State University | Methods, systems, and compositions for extracellular matrix production |
| EP2526967A1 (en) * | 2007-07-17 | 2012-11-28 | Merck Patent GmbH | Engineered anti-alpha v-integrin hybrid antibodies |
| WO2009026328A2 (en) | 2007-08-21 | 2009-02-26 | Immune Disease Institute, Inc. | Methods of delivery of agents to leukocytes and endothelial cells |
| DK2368118T3 (da) | 2008-12-23 | 2013-11-25 | Merck Patent Gmbh | Biomarkører til inhibitorer med anti-angiogen aktivitet |
| EP2467401B1 (en) | 2009-08-19 | 2017-01-18 | Merck Patent GmbH | Antibodies for the detection of integrin complexes in ffpe material |
| US20120263739A1 (en) | 2009-11-13 | 2012-10-18 | Merck Patent Gmbh | Anti integrin antibodies linked to nanoparticles loaded with chemotherapeutic agents |
| TR201810294T4 (tr) | 2011-02-11 | 2018-08-27 | Merck Patent Gmbh | Prostat kanseri tedavisi için anti-alfa-v integrin antikoru. |
| JP6035716B2 (ja) | 2011-08-26 | 2016-11-30 | ソニー株式会社 | 情報処理システム及び情報処理方法 |
| WO2014143383A1 (en) | 2013-03-13 | 2014-09-18 | Agilent Technologies, Inc. | Transposome tethered to a gene delivery vehicle |
| AU2014318017B2 (en) | 2013-09-05 | 2020-02-06 | Amgen Inc. | Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles |
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2012
- 2012-02-07 TR TR2018/10294T patent/TR201810294T4/tr unknown
- 2012-02-07 JP JP2013552879A patent/JP6320042B2/ja active Active
- 2012-02-07 MX MX2017014184A patent/MX385144B/es unknown
- 2012-02-07 PT PT12702990T patent/PT2672994T/pt unknown
- 2012-02-07 EP EP12702990.8A patent/EP2672994B1/en active Active
- 2012-02-07 LT LTEP12702990.8T patent/LT2672994T/lt unknown
- 2012-02-07 EA EA201391147A patent/EA032117B1/ru not_active IP Right Cessation
- 2012-02-07 MX MX2013009062A patent/MX352025B/es active IP Right Grant
- 2012-02-07 SG SG2013060140A patent/SG192667A1/en unknown
- 2012-02-07 US US13/984,669 patent/US9555110B2/en active Active
- 2012-02-07 EP EP18170936.1A patent/EP3415162A1/en not_active Withdrawn
- 2012-02-07 ES ES12702990.8T patent/ES2683347T3/es active Active
- 2012-02-07 KR KR1020197011392A patent/KR102103701B1/ko not_active Expired - Fee Related
- 2012-02-07 PL PL12702990T patent/PL2672994T3/pl unknown
- 2012-02-07 KR KR1020137023946A patent/KR101972533B1/ko not_active Expired - Fee Related
- 2012-02-07 DK DK12702990.8T patent/DK2672994T3/en active
- 2012-02-07 SI SI201231356T patent/SI2672994T1/sl unknown
- 2012-02-07 AU AU2012216145A patent/AU2012216145B2/en not_active Ceased
- 2012-02-07 HR HRP20181212TT patent/HRP20181212T1/hr unknown
- 2012-02-07 WO PCT/EP2012/000548 patent/WO2012107211A1/en not_active Ceased
- 2012-02-07 HU HUE12702990A patent/HUE037212T2/hu unknown
- 2012-02-07 CA CA2827052A patent/CA2827052C/en active Active
- 2012-02-07 CN CN201280008336.1A patent/CN103347540B/zh active Active
- 2012-02-07 RS RS20180926A patent/RS57524B1/sr unknown
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2013
- 2013-07-29 IL IL227687A patent/IL227687B/en active IP Right Grant
- 2013-09-10 ZA ZA2013/06807A patent/ZA201306807B/en unknown
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2016
- 2016-12-26 JP JP2016250652A patent/JP6488273B2/ja not_active Expired - Fee Related
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2017
- 2017-01-09 US US15/401,971 patent/US20170218070A1/en not_active Abandoned
- 2017-02-14 AU AU2017200998A patent/AU2017200998B2/en not_active Ceased
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2019
- 2019-01-25 US US16/258,289 patent/US20190263913A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011162933A1 (en) * | 2010-06-04 | 2011-12-29 | Immunogen, Inc. | Anti-integrin immunoconjugate dosing regimens |
Non-Patent Citations (9)
| Title |
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| "A study to determine the safety, tolerability, pharmacokinetics and dynamic effects of different doses of the study drug EM525797 in prostate cancer", Clinicaltrials. gov, 11 August 2009 (2009-08-11), XP002675310, Retrieved from the Internet: URL:http://www.clinicaltrials.gov/ct2/show/NCT00958477?term=emd525797&rank=3, [retrieved on 2012-05-04], the whole document * |
| BISANZ, K. YU, J. EDLUND, M. SPOHN, B. HUNG, M.C. CHUNG, L.W.K. HSIEH, C.L.: "Targeting ECM-Integrin Interaction with Liposome-Encapsulated Small Interfering RNAs Inhibits the Growth of Human Prostate Cancer in a Bone Xenograft Imaging Model", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 12, no. 4, 1 October 2005 (2005-10-01), GB, pages 634 - 643, XP005078442, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2005.05.012 * |
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| MILLARD M, ODDE S, NEAMATI N: "Integrin Targeted Therapeutics", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 1, 17 February 2011 (2011-02-17), AU, pages 154 - 188, XP002675313, ISSN: 1838-7640, DOI: 10.7150/thno/v01p0154 * |
| UNKNOWN: "Product data sheet of Anti-Integrin alpha(v) (Ab-1) Mouse mAb (272-17E6) and corresponding safety data sheet", INTERNET CITATION, [Online], pages 1-2,1, XP002615477, Retrieved from the Internet: URL:http://www.merck-chemicals.com/usa/life-science-research/anti-integrin-alpha-v-ab-1-mouse-mab-272-17e6/EMD_BIO-407286/p_JR6b.s1LruAAAAEWZmEfVhTm>, [retrieved on 2010-12-23], the whole document * |
| WAGNER, S. ; ROTHWEILER, F. ; ANHORN, M.G. ; SAUER, D. ; RIEMANN, I. ; WEISS, E.C. ; KATSEN-GLOBA, A. ; MICHAELIS, M. ; CINATL, J.: "Enhanced drug targeting by attachment of an anti +/-v integrin antibody to doxorubicin loaded human serum albumin nanoparticles", BIOMATERIALS., ELSEVIER SCIENCE PUBLISHERS BV., BARKING., GB, vol. 31, no. 8, 1 March 2010 (2010-03-01), GB, pages 2388 - 2398, XP026870608, ISSN: 0142-9612 * |
| Wirth et al.: European J. Canc., vol. 47, no. supp. 1, 23 September 2011 (2011-09-23), page S488, XP002675312, DOI: http://dx.doi.org/10.1016/50959-8049(11)71, 964-5, Retrieved from the Internet: URL:http://www.sciencedirect.com/science/article/pii/S0959804911719645, [retrieved on 2012-05-04], the whole document * |
| Wirth et al.: J. Clin. Oncol., vol. 29 suppl., E15060, 20 May 2011 (2011-05-20), XP002675311, Retrieved from the Internet: URL:http://meeting.ascopubs.org/cgi/content/abstract/29/15_suppl/e15060?sid=e353144d-d8a6-4f66-8489-615fc0e23f59, [retrieved on 2012-05-04], the whole document * |
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