EA027970B1 - Полиморфы ингибитора киназы - Google Patents

Полиморфы ингибитора киназы Download PDF

Info

Publication number
EA027970B1
EA027970B1 EA201490446A EA201490446A EA027970B1 EA 027970 B1 EA027970 B1 EA 027970B1 EA 201490446 A EA201490446 A EA 201490446A EA 201490446 A EA201490446 A EA 201490446A EA 027970 B1 EA027970 B1 EA 027970B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
acid
formula
solvent
compounds
Prior art date
Application number
EA201490446A
Other languages
English (en)
Russian (ru)
Other versions
EA201490446A1 (ru
Inventor
Пинда Жэнь
Майкл Мартин
Original Assignee
ИНТЕЛЛАЙКИН, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47669006&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA027970(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ИНТЕЛЛАЙКИН, ЭлЭлСи filed Critical ИНТЕЛЛАЙКИН, ЭлЭлСи
Publication of EA201490446A1 publication Critical patent/EA201490446A1/ru
Publication of EA027970B1 publication Critical patent/EA027970B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201490446A 2011-08-11 2012-08-10 Полиморфы ингибитора киназы EA027970B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161522624P 2011-08-11 2011-08-11
PCT/US2012/050453 WO2013023184A1 (en) 2011-08-11 2012-08-10 Kinase inhibitor polymorphs

Publications (2)

Publication Number Publication Date
EA201490446A1 EA201490446A1 (ru) 2014-05-30
EA027970B1 true EA027970B1 (ru) 2017-09-29

Family

ID=47669006

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490446A EA027970B1 (ru) 2011-08-11 2012-08-10 Полиморфы ингибитора киназы

Country Status (25)

Country Link
US (1) US20150065524A1 (enExample)
EP (1) EP2741749A4 (enExample)
JP (1) JP2014521726A (enExample)
KR (1) KR20140079368A (enExample)
CN (1) CN103957918A (enExample)
AU (1) AU2012294202B2 (enExample)
BR (1) BR112014003214A2 (enExample)
CA (1) CA2844742A1 (enExample)
CL (1) CL2014000343A1 (enExample)
CO (1) CO6960542A2 (enExample)
CR (1) CR20140082A (enExample)
DO (1) DOP2014000027A (enExample)
EA (1) EA027970B1 (enExample)
EC (1) ECSP14013236A (enExample)
HK (1) HK1199203A1 (enExample)
IL (1) IL230850A0 (enExample)
MX (1) MX2014001662A (enExample)
MY (1) MY186267A (enExample)
PE (1) PE20141358A1 (enExample)
PH (1) PH12014500331A1 (enExample)
RU (1) RU2636588C2 (enExample)
SG (2) SG2014009492A (enExample)
TN (1) TN2014000063A1 (enExample)
WO (1) WO2013023184A1 (enExample)
ZA (1) ZA201401211B (enExample)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1747747B (zh) 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
MX2011005963A (es) 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
AU2010239069B2 (en) 2009-04-20 2015-05-14 Angiochem Inc Treatment of ovarian cancer using an anticancer agent conjugated to an Angiopep-2 analog
MX2012000016A (es) 2009-07-02 2012-03-26 Angiochem Inc Conjugados de peptidos multimericos y sus usos.
CN106924741A (zh) * 2011-11-08 2017-07-07 因特利凯有限责任公司 使用多种药剂的治疗方案
CN104250250A (zh) * 2013-06-25 2014-12-31 苏州科捷生物医药有限公司 4-芳香胺基嘧啶类化合物及其抗肿瘤用途
CN105899232A (zh) 2013-11-13 2016-08-24 诺华股份有限公司 用于增强免疫应答的mTOR抑制剂
CA2931684C (en) 2013-12-19 2024-02-20 Novartis Ag Human mesothelin chimeric antigen receptors and uses thereof
EP3087101B1 (en) 2013-12-20 2024-06-05 Novartis AG Regulatable chimeric antigen receptor
EP3593812A3 (en) 2014-03-15 2020-05-27 Novartis AG Treatment of cancer using chimeric antigen receptor
IL322264A (en) 2014-04-07 2025-09-01 Novartis Ag Cancer treatment using chimeric antigen receptor (CAR) against CD19
US11542488B2 (en) 2014-07-21 2023-01-03 Novartis Ag Sortase synthesized chimeric antigen receptors
WO2016014530A1 (en) 2014-07-21 2016-01-28 Novartis Ag Combinations of low, immune enhancing. doses of mtor inhibitors and cars
US9777061B2 (en) 2014-07-21 2017-10-03 Novartis Ag Treatment of cancer using a CD33 chimeric antigen receptor
US20170209492A1 (en) 2014-07-31 2017-07-27 Novartis Ag Subset-optimized chimeric antigen receptor-containing t-cells
WO2016025880A1 (en) 2014-08-14 2016-02-18 Novartis Ag Treatment of cancer using gfr alpha-4 chimeric antigen receptor
SG11201700770PA (en) 2014-08-19 2017-03-30 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
ES2891332T3 (es) 2014-09-17 2022-01-27 Novartis Ag Direccionamiento a células citotóxicas con receptores quiméricos para la inmunoterapia adoptiva
AU2015330898B2 (en) 2014-10-08 2022-03-10 Novartis Ag Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
EP3280795B1 (en) 2015-04-07 2021-03-24 Novartis AG Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
AU2016249005B2 (en) 2015-04-17 2022-06-16 Novartis Ag Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells
EP3286211A1 (en) 2015-04-23 2018-02-28 Novartis AG Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
ES2636646B1 (es) * 2016-04-05 2018-08-03 Universidade De Santiago De Compostela NUEVOS VEHÍCULOS PARA LA TRANSFECCIÓN DE miRNAs
CN109641947B (zh) 2016-07-20 2023-04-14 犹他大学研究基金会 Cd229 car t细胞及其使用方法
WO2018067992A1 (en) 2016-10-07 2018-04-12 Novartis Ag Chimeric antigen receptors for the treatment of cancer
KR20190084310A (ko) 2016-11-23 2019-07-16 바이엘 크롭사이언스 악티엔게젤샤프트 살충제로서의 2-[3-(알킬술포닐)-2H-인다졸-2-일]-3H-이미다조[4,5-b]피리딘 유도체 및 유사한 화합물
US20200055948A1 (en) 2017-04-28 2020-02-20 Novartis Ag Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
BR112020013794B1 (pt) * 2018-01-09 2023-05-02 Halcyon Labs Private Limited Processo para a preparação de crisaborola de fórmula (i), compostos, uso de um composto de fórmula (iv), (iii) ou (ii), processo para a preparação de crisaborola altamente pura e sal
EP3784351A1 (en) 2018-04-27 2021-03-03 Novartis AG Car t cell therapies with enhanced efficacy
EP3788369A1 (en) 2018-05-01 2021-03-10 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080319075A1 (en) * 2002-07-18 2008-12-25 Ronit Yahalomi Polymorphic forms of nateglinide
US20100184760A1 (en) * 2008-11-03 2010-07-22 Pingda Ren Benzoxazole kinase inhibitors and methods of use
US20120184568A1 (en) * 2011-01-10 2012-07-19 Pingda Ren Processes for preparing isoquinolinones and solid forms of isoquinolinones

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080319075A1 (en) * 2002-07-18 2008-12-25 Ronit Yahalomi Polymorphic forms of nateglinide
US20100184760A1 (en) * 2008-11-03 2010-07-22 Pingda Ren Benzoxazole kinase inhibitors and methods of use
US20120184568A1 (en) * 2011-01-10 2012-07-19 Pingda Ren Processes for preparing isoquinolinones and solid forms of isoquinolinones

Also Published As

Publication number Publication date
NZ622208A (en) 2016-04-29
KR20140079368A (ko) 2014-06-26
PE20141358A1 (es) 2014-10-12
CR20140082A (es) 2014-06-03
PH12014500331A1 (en) 2014-03-31
TN2014000063A1 (en) 2015-07-01
WO2013023184A1 (en) 2013-02-14
MY186267A (en) 2021-07-01
AU2012294202A1 (en) 2014-03-06
AU2012294202B2 (en) 2017-02-23
CL2014000343A1 (es) 2014-10-17
ECSP14013236A (es) 2014-06-30
SG2014009492A (en) 2014-09-26
CA2844742A1 (en) 2013-02-14
EP2741749A4 (en) 2015-04-15
RU2014109023A (ru) 2015-09-20
MX2014001662A (es) 2014-08-26
DOP2014000027A (es) 2014-07-15
JP2014521726A (ja) 2014-08-28
BR112014003214A2 (pt) 2017-03-14
CN103957918A (zh) 2014-07-30
IL230850A0 (en) 2014-03-31
EA201490446A1 (ru) 2014-05-30
CO6960542A2 (es) 2014-05-30
US20150065524A1 (en) 2015-03-05
HK1199203A1 (en) 2015-06-26
ZA201401211B (en) 2015-12-23
SG10201606288TA (en) 2016-09-29
RU2636588C2 (ru) 2017-11-24
EP2741749A1 (en) 2014-06-18

Similar Documents

Publication Publication Date Title
RU2636588C2 (ru) Полиморфы ингибитора киназы
AU2016322552B2 (en) Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
AU2014331628B2 (en) Inhibitors of ERK and methods of use
CN112778276A (zh) 作为shp2抑制剂的化合物及其应用
JP6078076B2 (ja) キナーゼ阻害剤多形体
JP2021008514A (ja) ベンゾオキサゾールキナーゼ阻害剤および使用方法
JP2014501790A (ja) イソキノリノンの調製方法及びイソキノリノンの固体形態
CA3137985A1 (en) Substituted pyrrolo [2, 3-b] pyridine and pyrazolo [3, 4-b] pyridine derivatives as protein kinase inhibitors
AU2013296627A1 (en) Deuterated ibrutinib
EP2970194A1 (en) Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
CN118063470A (zh) 作为PI3K-γ抑制剂的由叔羟基取代的缩合咪唑衍生物
UA124074C2 (uk) Аналоги карбануклеозиду, заміщені моноциклічною та біциклічною кільцевою системою, для застосування як інгібіторів prmt5
TW202220987A (zh) 經取代雜環化合物及其治療用途
JP2022521491A (ja) タンパク質アルギニンメチルトランスフェラーゼ5(prmt5)の選択的阻害剤
JP2016540812A (ja) 癌の治療用のfasn阻害剤として有用なイミダゾリン−5−オン誘導体
KR101796779B1 (ko) 다이하이드로프테리딘-온 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
WO2023049270A1 (en) Pyrrole[2,3-b]pyridine derivatives as tyro3 inhibitors
HK40129489A (en) Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
HK40061853B (zh) 用作cdk7激酶抑制剂的化合物及其应用
NZ622208B2 (en) Kinase inhibitor polymorphs

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

PC4A Registration of transfer of a eurasian patent by assignment