EA024791B1 - НОВЫЕ МАКРОЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ ФАКТОРА XIa - Google Patents

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Publication number

EA024791B1

EA024791B1 EA201490418A EA201490418A EA024791B1 EA 024791 B1 EA024791 B1 EA 024791B1 EA 201490418 A EA201490418 A EA 201490418A EA 201490418 A EA201490418 A EA 201490418A EA 024791 B1 EA024791 B1 EA 024791B1

Authority

EA

Eurasian Patent Office

Prior art keywords

alkyl

mmol

compounds

thrombosis

concentrated

Prior art date

2011-08-05

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• 239000003112 inhibitor Substances 0.000 title abstract description 60
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• 125000000217 alkyl group Chemical group 0.000 claims description 92
• 208000007536 Thrombosis Diseases 0.000 claims description 51
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 51
• 229910052739 hydrogen Inorganic materials 0.000 claims description 46
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 42
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 38
• 125000000623 heterocyclic group Chemical group 0.000 claims description 37
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• 229910052736 halogen Inorganic materials 0.000 claims description 30
• 150000002367 halogens Chemical class 0.000 claims description 28
• 238000011282 treatment Methods 0.000 claims description 27
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 26
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 26
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 22
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 19
• 229910052760 oxygen Inorganic materials 0.000 claims description 18
• 125000005842 heteroatom Chemical group 0.000 claims description 17
• 125000003118 aryl group Chemical group 0.000 claims description 16
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• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
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