EA021683B1 - Производные деоксиактагардина в - Google Patents

Производные деоксиактагардина в Download PDF

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Publication number
EA021683B1
EA021683B1 EA201190071A EA201190071A EA021683B1 EA 021683 B1 EA021683 B1 EA 021683B1 EA 201190071 A EA201190071 A EA 201190071A EA 201190071 A EA201190071 A EA 201190071A EA 021683 B1 EA021683 B1 EA 021683B1
Authority
EA
Eurasian Patent Office
Prior art keywords
deoxyactagardine
infection
compounds
present
amino
Prior art date
Application number
EA201190071A
Other languages
English (en)
Russian (ru)
Other versions
EA201190071A1 (ru
Inventor
Сьёрд Николаас Вадман
Original Assignee
Новакта Биосистемс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новакта Биосистемс Лимитед filed Critical Новакта Биосистемс Лимитед
Publication of EA201190071A1 publication Critical patent/EA201190071A1/ru
Publication of EA021683B1 publication Critical patent/EA021683B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EA201190071A 2009-01-14 2010-01-12 Производные деоксиактагардина в EA021683B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14449009P 2009-01-14 2009-01-14
PCT/GB2010/000042 WO2010082018A1 (en) 2009-01-14 2010-01-12 Deoxyactagardine derivatives

Publications (2)

Publication Number Publication Date
EA201190071A1 EA201190071A1 (ru) 2012-06-29
EA021683B1 true EA021683B1 (ru) 2015-08-31

Family

ID=42110329

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190071A EA021683B1 (ru) 2009-01-14 2010-01-12 Производные деоксиактагардина в

Country Status (22)

Country Link
US (2) US8283371B2 (enExample)
EP (1) EP2387580B1 (enExample)
JP (1) JP5719312B2 (enExample)
KR (1) KR20110119699A (enExample)
CN (1) CN102348718B (enExample)
AU (1) AU2010205472B2 (enExample)
CA (1) CA2749278A1 (enExample)
DK (1) DK2387580T3 (enExample)
EA (1) EA021683B1 (enExample)
ES (1) ES2520165T3 (enExample)
HR (1) HRP20141084T1 (enExample)
IL (1) IL213927A0 (enExample)
MX (1) MX2011007313A (enExample)
NZ (1) NZ594011A (enExample)
PL (1) PL2387580T3 (enExample)
PT (1) PT2387580E (enExample)
RS (1) RS53586B1 (enExample)
SG (1) SG172944A1 (enExample)
SI (1) SI2387580T1 (enExample)
TW (1) TWI453029B (enExample)
WO (1) WO2010082018A1 (enExample)
ZA (1) ZA201104991B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714029D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
NZ594011A (en) 2009-01-14 2013-12-20 Novacta Biosystems Ltd Deoxyactagardine derivatives
KR20110122139A (ko) 2009-02-04 2011-11-09 노박타 바이오시스템스 리미티드 액타가르딘 유도체
WO2011061748A1 (en) * 2009-11-19 2011-05-26 Strides Arcolab Limited Rifaximin premix
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
GB201013507D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013509D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013508D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201213434D0 (en) 2012-07-27 2012-09-12 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0195359A2 (en) * 1985-03-22 1986-09-24 GRUPPO LEPETIT S.p.A. Basic monocarboxyamide derivatives of actagardine having antibiotic activity
WO2007083112A2 (en) * 2006-01-17 2007-07-26 Novacta Biosystems Limited Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US5304540A (en) 1988-06-22 1994-04-19 Applied Microbiology, Inc. Pharmaceutical bacteriocin compositions and methods for using the same
IN167138B (enExample) 1988-08-17 1990-09-01 Hoechst India
GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
IT1260505B (it) 1992-06-01 1996-04-09 Poli Ind Chimica Spa Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon
IL107887A (en) 1992-12-08 2003-07-06 Ambi Inc Stabilized lanthionine containing bacteriocin compositions
US5512269A (en) 1993-06-09 1996-04-30 Burroughs Wellcome, Co. Method of treating retained pulmonary secretions
PT700998E (pt) 1994-09-12 2004-03-31 Aventis Pharma Gmbh Mersacidina recombinante e metodo para a sua producao
BR9609281A (pt) 1995-06-23 1999-06-15 Ambi Inc Método para o controle de bactérias gram-positivas resistentes a antibióticos e tratamento de infecções
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5985823A (en) 1997-06-09 1999-11-16 Ambi Inc. Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
US5958873A (en) 1997-06-09 1999-09-28 University Of Cincinnati Oral formulation for treatment of bacteria-induced diseases of the colon
DE19745583A1 (de) 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US6569830B1 (en) 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
JP4188078B2 (ja) 2000-06-28 2008-11-26 スミスクライン ビーチャム ピー エル シー 湿式粉砕法
GB0110432D0 (en) 2001-04-27 2001-06-20 Plant Bioscience Ltd Lantibiotic production
WO2002103010A1 (en) 2001-06-14 2002-12-27 Plant Bioscience Limited Methods and materials for targeted gene disruption in actinomycete bacteria
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
US7199230B2 (en) 2002-10-10 2007-04-03 Molichem Medicines, Inc. Nucleic acids encoding duramycin
US7351687B2 (en) 2003-07-18 2008-04-01 Vicuron Pharmaceuticals, Inc. Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof
MXPA06000691A (es) 2003-07-18 2006-04-11 Vicuron Pharm Inc Antibiotico 107891, sus factores a1 y a2, sales y composiciones farmaceuticamente aceptables y uso de las mismas.
GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
JP2009509519A (ja) 2005-09-27 2009-03-12 ノヴァクタ バイオシステムズ リミティッド ランチビオティックメルサシジンの変種およびそれらの使用
WO2008050209A1 (en) 2006-10-27 2008-05-02 Pfizer Products Inc. Hydroxypropyl methyl cellulose hard capsules and process of manufacture
CA2690267A1 (en) 2007-06-12 2008-12-18 The University Of British Columbia Small cationic antimicrobial peptides
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
KR20110086582A (ko) 2008-11-24 2011-07-28 센티넬라 파마세티컬즈, 인크. 항균활성이 강화된 란티바이오틱 카르복시아미드 유도체
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
NZ594011A (en) 2009-01-14 2013-12-20 Novacta Biosystems Ltd Deoxyactagardine derivatives
KR20110122139A (ko) 2009-02-04 2011-11-09 노박타 바이오시스템스 리미티드 액타가르딘 유도체

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0195359A2 (en) * 1985-03-22 1986-09-24 GRUPPO LEPETIT S.p.A. Basic monocarboxyamide derivatives of actagardine having antibiotic activity
WO2007083112A2 (en) * 2006-01-17 2007-07-26 Novacta Biosystems Limited Lantibiotic biosynthetic gene clusters from a. garbadinensis and a. liguriae

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BOAKES STEVEN ET AL.: "Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system", MOLECULAR MICROBIOLOGY, vol. 72, no. 5, June 2009 (2009-06), pages 1126-1136, XP002580259, ISSN: 0950-382X, page 1131, column 2, fig. 4 *
MALABARBA A. ET AL.: "SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME AMIDE DERIVATIVES OF THE LANTIBIOTIC ACTAGARDINE", JOURNAL OF ANTIBIOTICS, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION, TOKYO, JP, vol. 43, no. 9, 1 September 1990 (1990-09-01), pages 1089-1097, XP000647318, ISSN: 0021-8820, the whole document *
ZIMMERMANN N. ET AL.: "THE TETRACYCLIC LANTIBIOTIC ACTAGARDINE H-NMR AND C-NMR ASSIGNMENTS AND REVISED PRIMARY STRUCTURE", EUROPEAN JOURNAL OF BIOCHEMISTRY, BLACKWELL PUBLISHING, BERLIN, DE LNKD- DOI:10.1111/J.1432-1033.1995.TB20324.X, vol. 228, no. 3, 15 March 1995 (1995-03-15), pages 786-797, XP000645986, ISSN: 0014-2956, the whole document *

Also Published As

Publication number Publication date
PT2387580E (pt) 2014-10-30
JP2012515195A (ja) 2012-07-05
SI2387580T1 (sl) 2014-11-28
CN102348718A (zh) 2012-02-08
KR20110119699A (ko) 2011-11-02
EP2387580A1 (en) 2011-11-23
ES2520165T3 (es) 2014-11-11
ZA201104991B (en) 2013-10-31
CN102348718B (zh) 2015-06-03
WO2010082018A1 (en) 2010-07-22
CA2749278A1 (en) 2010-07-22
US8741945B2 (en) 2014-06-03
MX2011007313A (es) 2011-08-04
TW201029661A (en) 2010-08-16
US20100179207A1 (en) 2010-07-15
DK2387580T3 (da) 2014-10-13
NZ594011A (en) 2013-12-20
EP2387580B1 (en) 2014-08-13
HRP20141084T1 (hr) 2015-02-13
US20120277145A1 (en) 2012-11-01
JP5719312B2 (ja) 2015-05-13
IL213927A0 (en) 2011-07-31
EA201190071A1 (ru) 2012-06-29
SG172944A1 (en) 2011-08-29
AU2010205472B2 (en) 2013-03-14
US8283371B2 (en) 2012-10-09
AU2010205472A1 (en) 2011-07-28
RS53586B1 (sr) 2015-02-27
PL2387580T3 (pl) 2015-01-30
TWI453029B (zh) 2014-09-21

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU