EA201190071A1 - Производные деоксиактагардина - Google Patents

Производные деоксиактагардина

Info

Publication number
EA201190071A1
EA201190071A1 EA201190071A EA201190071A EA201190071A1 EA 201190071 A1 EA201190071 A1 EA 201190071A1 EA 201190071 A EA201190071 A EA 201190071A EA 201190071 A EA201190071 A EA 201190071A EA 201190071 A1 EA201190071 A1 EA 201190071A1
Authority
EA
Eurasian Patent Office
Prior art keywords
infections
deoksiaktagardina
derivatives
difficile
compounds
Prior art date
Application number
EA201190071A
Other languages
English (en)
Other versions
EA021683B1 (ru
Inventor
Сьёрд Николаас Вадман
Original Assignee
Новакта Биосистемс Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новакта Биосистемс Лимитед filed Critical Новакта Биосистемс Лимитед
Publication of EA201190071A1 publication Critical patent/EA201190071A1/ru
Publication of EA021683B1 publication Critical patent/EA021683B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится в целом к конкретным соединениям-аналогам деоксиактагардина типа А и В. Указанные соединения подходят для применения для лечения микробных инфекций, например, инфекции Clostridiumтакой как С. perfringens, С. difficile, C.tetaniи/или С. botulinumв частности С. difficileв частности инфекции толстой кишки и/или нижних отделов кишечника, и диареи, вызванной микробной инфекцией.
EA201190071A 2009-01-14 2010-01-12 Производные деоксиактагардина в EA021683B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14449009P 2009-01-14 2009-01-14
PCT/GB2010/000042 WO2010082018A1 (en) 2009-01-14 2010-01-12 Deoxyactagardine derivatives

Publications (2)

Publication Number Publication Date
EA201190071A1 true EA201190071A1 (ru) 2012-06-29
EA021683B1 EA021683B1 (ru) 2015-08-31

Family

ID=42110329

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190071A EA021683B1 (ru) 2009-01-14 2010-01-12 Производные деоксиактагардина в

Country Status (22)

Country Link
US (2) US8283371B2 (ru)
EP (1) EP2387580B1 (ru)
JP (1) JP5719312B2 (ru)
KR (1) KR20110119699A (ru)
CN (1) CN102348718B (ru)
AU (1) AU2010205472B2 (ru)
CA (1) CA2749278A1 (ru)
DK (1) DK2387580T3 (ru)
EA (1) EA021683B1 (ru)
ES (1) ES2520165T3 (ru)
HR (1) HRP20141084T1 (ru)
IL (1) IL213927A0 (ru)
MX (1) MX2011007313A (ru)
NZ (1) NZ594011A (ru)
PL (1) PL2387580T3 (ru)
PT (1) PT2387580E (ru)
RS (1) RS53586B1 (ru)
SG (1) SG172944A1 (ru)
SI (1) SI2387580T1 (ru)
TW (1) TWI453029B (ru)
WO (1) WO2010082018A1 (ru)
ZA (1) ZA201104991B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714030D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) * 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
DK2387580T3 (da) 2009-01-14 2014-10-13 Novacta Biosystems Ltd Deoxyactagardinderivater
EA020733B1 (ru) 2009-02-04 2015-01-30 Новакта Биосистемс Лимитед Производные актагардина
WO2011061748A1 (en) * 2009-11-19 2011-05-26 Strides Arcolab Limited Rifaximin premix
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013507D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013509D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
GB201013508D0 (en) * 2010-08-11 2010-09-22 Novacta Biosystems Ltd Compounds
GB201213434D0 (en) 2012-07-27 2012-09-12 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity

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GB8926639D0 (en) 1989-11-24 1990-01-17 Agricultural & Food Res Delayed release formulations
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IL107887A (en) * 1992-12-08 2003-07-06 Ambi Inc Stabilized lanthionine containing bacteriocin compositions
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ATE255165T1 (de) 1994-09-12 2003-12-15 Aventis Pharma Gmbh Rekombinantes mersacidin und verfahren zu seiner herstellung
US5866539A (en) 1995-06-23 1999-02-02 Ambi Inc. Method for the control of antibiotic-resistant gram positive bacteria and treatment of infection
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
US5958873A (en) 1997-06-09 1999-09-28 University Of Cincinnati Oral formulation for treatment of bacteria-induced diseases of the colon
US5985823A (en) * 1997-06-09 1999-11-16 Ambi Inc. Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
DE19745583A1 (de) 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US6569830B1 (en) * 1999-03-05 2003-05-27 Ambi, Inc. Compositions and methods for treatment of staphylococcal infection while suppressing formation of antibiotic-resistant strains
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WO2002103010A1 (en) 2001-06-14 2002-12-27 Plant Bioscience Limited Methods and materials for targeted gene disruption in actinomycete bacteria
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GB0406870D0 (en) 2004-03-26 2004-04-28 Novacta Biosystems Ltd Improvements relating to the production of lantibiotics
EP1928900A1 (en) 2005-09-27 2008-06-11 Novacta Biosystems Limited Variants of the lantibiotic mersacidin and their use
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GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
AU2008364202A1 (en) 2008-11-24 2011-07-07 Sentinella Pharmaceuticals, Inc. ("Sentinella") Lantibiotic carboxyamide derivatives with enhanced antibacterial activity
GB0900599D0 (en) 2009-01-14 2009-02-18 Novacta Biosystems Ltd Treatment
DK2387580T3 (da) 2009-01-14 2014-10-13 Novacta Biosystems Ltd Deoxyactagardinderivater
EA020733B1 (ru) 2009-02-04 2015-01-30 Новакта Биосистемс Лимитед Производные актагардина

Also Published As

Publication number Publication date
JP5719312B2 (ja) 2015-05-13
IL213927A0 (en) 2011-07-31
ES2520165T3 (es) 2014-11-11
TW201029661A (en) 2010-08-16
ZA201104991B (en) 2013-10-31
CN102348718B (zh) 2015-06-03
RS53586B1 (sr) 2015-02-27
EP2387580A1 (en) 2011-11-23
US20100179207A1 (en) 2010-07-15
HRP20141084T1 (hr) 2015-02-13
PT2387580E (pt) 2014-10-30
JP2012515195A (ja) 2012-07-05
WO2010082018A1 (en) 2010-07-22
NZ594011A (en) 2013-12-20
US20120277145A1 (en) 2012-11-01
EP2387580B1 (en) 2014-08-13
AU2010205472A1 (en) 2011-07-28
SG172944A1 (en) 2011-08-29
EA021683B1 (ru) 2015-08-31
SI2387580T1 (sl) 2014-11-28
KR20110119699A (ko) 2011-11-02
DK2387580T3 (da) 2014-10-13
MX2011007313A (es) 2011-08-04
US8741945B2 (en) 2014-06-03
CN102348718A (zh) 2012-02-08
AU2010205472B2 (en) 2013-03-14
CA2749278A1 (en) 2010-07-22
US8283371B2 (en) 2012-10-09
TWI453029B (zh) 2014-09-21
PL2387580T3 (pl) 2015-01-30

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU