EA020071B1 - Замещенные производные триазолопиридазина - Google Patents
Замещенные производные триазолопиридазина Download PDFInfo
- Publication number
- EA020071B1 EA020071B1 EA201100409A EA201100409A EA020071B1 EA 020071 B1 EA020071 B1 EA 020071B1 EA 201100409 A EA201100409 A EA 201100409A EA 201100409 A EA201100409 A EA 201100409A EA 020071 B1 EA020071 B1 EA 020071B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- present
- compounds
- deuterium
- pharmaceutically acceptable
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- C—CHEMISTRY; METALLURGY
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- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
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| US9329308P | 2008-08-29 | 2008-08-29 | |
| PCT/US2009/055427 WO2010025407A1 (en) | 2008-08-29 | 2009-08-28 | Substituted triazolo-pyridazine derivatives |
Publications (2)
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| EA201100409A1 EA201100409A1 (ru) | 2011-10-31 |
| EA020071B1 true EA020071B1 (ru) | 2014-08-29 |
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| EA201100409A EA020071B1 (ru) | 2008-08-29 | 2009-08-28 | Замещенные производные триазолопиридазина |
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| EP (2) | EP2328414B1 (https=) |
| JP (3) | JP5183808B2 (https=) |
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| CN (2) | CN104098578A (https=) |
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| BR (1) | BRPI0912928A2 (https=) |
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| PT (1) | PT2328414E (https=) |
| WO (1) | WO2010025407A1 (https=) |
| ZA (1) | ZA201102123B (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2735549A1 (en) | 2008-08-29 | 2010-03-04 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
| EP2340782A4 (en) | 2008-10-03 | 2014-04-02 | Inst Alberto Luiz Coimbra De Pos Graduacao E Pesquisa De Engenharia Coppe Ufrj | METHOD AND DEVICE FOR REMOVING METAL FRAGMENTS AND METAL ELEMENTS FROM TOOTH ROOT CHANNELS |
| US8501738B2 (en) | 2009-06-23 | 2013-08-06 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
| RU2014120166A (ru) | 2011-10-20 | 2015-11-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные бициклические аза-гетероциклы и их аналоги в качестве модуляторов сиртуина |
| EP2768834B1 (en) * | 2011-10-20 | 2016-04-27 | Glaxosmithkline LLC | Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators |
| EP2802569B1 (de) | 2012-01-11 | 2016-01-06 | Bayer Intellectual Property GmbH | Tetrazol-5-yl- und triazol-5-yl-arylverbindungen und ihre verwendung als herbizide |
| US20150158870A1 (en) * | 2012-05-11 | 2015-06-11 | Concert Pharmaceuticals Inc. | Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
| EP2847195A1 (en) * | 2012-05-11 | 2015-03-18 | Concert Pharmaceuticals Inc. | Form 2 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
| US20150099753A1 (en) * | 2012-05-11 | 2015-04-09 | Concert Pharmaceuticals Inc. | Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine |
| WO2015052173A1 (en) | 2013-10-10 | 2015-04-16 | Basf Se | Tetrazole and triazole compounds and their use as herbicides |
| WO2015052178A1 (en) | 2013-10-10 | 2015-04-16 | Basf Se | 1,2,5-oxadiazole compounds and their use as herbicides |
| WO2015095549A1 (en) * | 2013-12-18 | 2015-06-25 | Concert Pharmaceuticals, Inc. | Dosage regimen for gabaa receptor subtype selective drug |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| CN104353078B (zh) * | 2014-11-24 | 2017-10-24 | 王寿世 | 一种麻醉用药物组合物 |
| CN104474549A (zh) * | 2014-11-24 | 2015-04-01 | 王寿世 | 异丙酚和gabaa受体拮抗剂在制备麻醉药物中的用途 |
| US10026332B1 (en) | 2017-04-10 | 2018-07-17 | Jasmine Gupta | Method to deliver contextual educational information utilizing smart wearables |
| SG11202109526PA (en) * | 2019-03-18 | 2021-10-28 | Neurocycle Therapeutics Inc | Use of gabaa receptor modulators for treatment of pain |
| WO2023205722A1 (en) * | 2022-04-20 | 2023-10-26 | Engrail Therapeutics, Inc. | Gabaa receptor modulator salts, particles, and uses thereof |
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| RU2136684C1 (ru) * | 1993-10-13 | 1999-09-10 | Кноль Аг | Производные 1,2,4-триазоло [1,5-a]пиримидинов, их фармацевтически приемлемые соли и стереоизомеры, фармацевтическая композиция и способ ингибирования припадков |
| US6255305B1 (en) * | 1996-07-25 | 2001-07-03 | Merck Sharp & Dohme Limited | Substituted triazolo-pyridazine derivatives as ligands for GABA receptors |
| US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| YU43800A (sh) * | 1998-01-21 | 2002-12-10 | Merck Sharp & Dohme Limited | Triazolo-piridazin derivati kao ligandi za gaba receptore |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| JP2002535407A (ja) * | 1999-01-27 | 2002-10-22 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体のリガンドとしてのトリアゾロピリダジン誘導体 |
| PT1104760E (pt) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| DE60315876T2 (de) * | 2002-11-28 | 2008-05-21 | Neurosearch A/S | Verfahren zum screening für verbindungen mit sedativer oder anxiolytischer potenz |
| WO2006061428A2 (en) | 2004-12-10 | 2006-06-15 | Universität Zürich | Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain |
| CN101309917B (zh) | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| US20080051422A1 (en) * | 2006-08-22 | 2008-02-28 | Concert Pharmaceuticals Inc. | 4-Aminoquinazoline derivatives and methods of use thereof |
| WO2008030382A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20080242687A1 (en) * | 2007-04-02 | 2008-10-02 | Auspex Pharmaceuticals, Inc. | Substituted pyrimidines |
| CA2735549A1 (en) | 2008-08-29 | 2010-03-04 | Concert Pharmaceuticals, Inc. | Substituted triazolo-pyridazine derivatives |
-
2009
- 2009-08-28 CA CA 2735549 patent/CA2735549A1/en not_active Abandoned
- 2009-08-28 MX MX2011002278A patent/MX2011002278A/es active IP Right Grant
- 2009-08-28 HR HRP20140195AT patent/HRP20140195T1/hr unknown
- 2009-08-28 US US12/550,346 patent/US8003646B2/en active Active
- 2009-08-28 PT PT98106859T patent/PT2328414E/pt unknown
- 2009-08-28 AU AU2009285533A patent/AU2009285533B2/en not_active Ceased
- 2009-08-28 DK DK09810685.9T patent/DK2328414T3/en active
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- 2009-08-28 CN CN201410346402.7A patent/CN104098578A/zh active Pending
- 2009-08-28 KR KR20117006632A patent/KR20110063479A/ko not_active Ceased
- 2009-08-28 EP EP20090810685 patent/EP2328414B1/en active Active
- 2009-08-28 EA EA201100409A patent/EA020071B1/ru not_active IP Right Cessation
- 2009-08-28 WO PCT/US2009/055427 patent/WO2010025407A1/en not_active Ceased
- 2009-08-28 CN CN200980140350.5A patent/CN102176826B/zh not_active Expired - Fee Related
- 2009-08-28 PL PL09810685T patent/PL2328414T3/pl unknown
- 2009-08-28 JP JP2011525250A patent/JP5183808B2/ja not_active Expired - Fee Related
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- 2009-08-28 EP EP20130196185 patent/EP2716158A1/en not_active Withdrawn
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2011
- 2011-03-22 ZA ZA2011/02123A patent/ZA201102123B/en unknown
- 2011-06-30 US US13/174,662 patent/US8399467B2/en active Active
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2013
- 2013-01-15 JP JP2013004449A patent/JP5373982B2/ja not_active Expired - Fee Related
- 2013-03-18 US US13/846,119 patent/US8921366B2/en active Active
- 2013-09-19 JP JP2013194060A patent/JP2014058518A/ja active Pending
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2014
- 2014-12-23 US US14/581,843 patent/US20150111895A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2136684C1 (ru) * | 1993-10-13 | 1999-09-10 | Кноль Аг | Производные 1,2,4-триазоло [1,5-a]пиримидинов, их фармацевтически приемлемые соли и стереоизомеры, фармацевтическая композиция и способ ингибирования припадков |
| US6255305B1 (en) * | 1996-07-25 | 2001-07-03 | Merck Sharp & Dohme Limited | Substituted triazolo-pyridazine derivatives as ligands for GABA receptors |
| US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
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