EA018447B1 - Применение комбинации 7-(2,5-дигидро-4-имидазо[1,2-а]пиридин-3-ил-2,5-диоксо-1н-пиррол-3-ил)-9-фтор-1,2,3,4-тетрагидро-2-(1-пиперидинилкарбонил)пирроло[3,2,1-jk][1,4]бензодиазепина с химиотерапевтическим агентом для лечения злокачественных опухолей - Google Patents
Применение комбинации 7-(2,5-дигидро-4-имидазо[1,2-а]пиридин-3-ил-2,5-диоксо-1н-пиррол-3-ил)-9-фтор-1,2,3,4-тетрагидро-2-(1-пиперидинилкарбонил)пирроло[3,2,1-jk][1,4]бензодиазепина с химиотерапевтическим агентом для лечения злокачественных опухолей Download PDFInfo
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- EA018447B1 EA018447B1 EA201070085A EA201070085A EA018447B1 EA 018447 B1 EA018447 B1 EA 018447B1 EA 201070085 A EA201070085 A EA 201070085A EA 201070085 A EA201070085 A EA 201070085A EA 018447 B1 EA018447 B1 EA 018447B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- fluoro
- dihydro
- carboplatin
- imidazo
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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| US94751207P | 2007-07-02 | 2007-07-02 | |
| PCT/US2008/067614 WO2009006043A2 (en) | 2007-07-02 | 2008-06-20 | Potentiation of cancer chemotherapy by 7-(2,5-dihydro-4-imidazo [1,2-a]pyrine-3-yl-2,5-dioxo-ih-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro-2-(1-piperidinyl-carbonyd-pyrrolo[3,2,1-jk][1,4]benzodiazepine |
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| EA201070085A1 EA201070085A1 (ru) | 2010-04-30 |
| EA018447B1 true EA018447B1 (ru) | 2013-08-30 |
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| EA201201155A EA023697B1 (ru) | 2007-07-02 | 2008-06-20 | ПРИМЕНЕНИЕ КОМБИНАЦИИ ИЗ 7-(2,5-ДИГИДРО-4-ИМИДАЗО[1,2-а]ПИРИДИН-3-ИЛ-2,5-ДИОКСО-1Н-ПИРРОЛ-3-ИЛ)-9-ФТОР-1,2,3,4-ТЕТРАГИДРО-2-(1-ПИПЕРИДИНИЛКАРБОНИЛ)ПИРРОЛО[3,2,1-jk][1,4]БЕНЗОДИАЗЕПИНА И ХИМИОТЕРАПЕВТИЧЕСКОГО АГЕНТА ДЛЯ ПОЛУЧЕНИЯ ЛЕКАРСТВЕННОГО СРЕДСТВА ДЛЯ ЛЕЧЕНИЯ РАКА ЖЕЛУДКА |
| EA201070085A EA018447B1 (ru) | 2007-07-02 | 2008-06-20 | Применение комбинации 7-(2,5-дигидро-4-имидазо[1,2-а]пиридин-3-ил-2,5-диоксо-1н-пиррол-3-ил)-9-фтор-1,2,3,4-тетрагидро-2-(1-пиперидинилкарбонил)пирроло[3,2,1-jk][1,4]бензодиазепина с химиотерапевтическим агентом для лечения злокачественных опухолей |
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| EA201201155A EA023697B1 (ru) | 2007-07-02 | 2008-06-20 | ПРИМЕНЕНИЕ КОМБИНАЦИИ ИЗ 7-(2,5-ДИГИДРО-4-ИМИДАЗО[1,2-а]ПИРИДИН-3-ИЛ-2,5-ДИОКСО-1Н-ПИРРОЛ-3-ИЛ)-9-ФТОР-1,2,3,4-ТЕТРАГИДРО-2-(1-ПИПЕРИДИНИЛКАРБОНИЛ)ПИРРОЛО[3,2,1-jk][1,4]БЕНЗОДИАЗЕПИНА И ХИМИОТЕРАПЕВТИЧЕСКОГО АГЕНТА ДЛЯ ПОЛУЧЕНИЯ ЛЕКАРСТВЕННОГО СРЕДСТВА ДЛЯ ЛЕЧЕНИЯ РАКА ЖЕЛУДКА |
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| EP (1) | EP2173348B1 (OSRAM) |
| JP (2) | JP5551589B2 (OSRAM) |
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| AU (1) | AU2008270732B2 (OSRAM) |
| BR (1) | BRPI0813789A2 (OSRAM) |
| CA (1) | CA2691587C (OSRAM) |
| CL (2) | CL2008001848A1 (OSRAM) |
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| MA (1) | MA31677B1 (OSRAM) |
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| MY (1) | MY154472A (OSRAM) |
| NZ (1) | NZ581355A (OSRAM) |
| PE (1) | PE20090838A1 (OSRAM) |
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| UA (1) | UA97400C2 (OSRAM) |
| WO (1) | WO2009006043A2 (OSRAM) |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
| PE20120772A1 (es) * | 2009-04-14 | 2012-06-27 | Lilly Co Eli | Derivado de benzodiazepina para el tratamiento de neoplasma hematopoyetico y leucemia |
| US20150017245A1 (en) * | 2011-09-22 | 2015-01-15 | Bind Therapeutics, Inc. | Methods of treating cancers with therapeutic nanoparticles |
| WO2014050779A1 (ja) * | 2012-09-25 | 2014-04-03 | 第一三共株式会社 | Ｇｓｋ３阻害剤と抗ｄｒ５抗体の組み合わせ |
| WO2016175324A1 (ja) * | 2015-04-30 | 2016-11-03 | 大鵬薬品工業株式会社 | 抗腫瘍剤の副作用軽減剤 |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US10213511B2 (en) * | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US10016507B2 (en) * | 2016-03-02 | 2018-07-10 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III |
| CN110392686A (zh) * | 2016-12-30 | 2019-10-29 | 频率治疗公司 | 1h-吡咯-2,5-二酮化合物以及使用它们来诱导干/祖支持细胞自我更新的方法 |
| AU2020218366A1 (en) | 2019-02-08 | 2021-09-16 | Frequency Therapeutics, Inc. | Valproic acid compounds and Wnt agonists for treating ear disorders |
| CA3222225A1 (en) * | 2021-06-03 | 2022-12-08 | University Of Cincinnati | Bzd-1 as a chemosensitizer of cancer |
| CN113956157B (zh) * | 2021-11-18 | 2024-05-03 | 西安都创医药科技有限公司 | 一种合成2-甲酰基-1-环丙烷甲酸乙酯的方法 |
Citations (1)
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| EP1788086A1 (en) * | 1997-03-17 | 2007-05-23 | Human Genome Sciences, Inc. | Death Domain Containing Receptor 5 |
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| GB8904161D0 (en) | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
| KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US7034013B2 (en) | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| KR100974770B1 (ko) | 2002-03-05 | 2010-08-06 | 일라이 릴리 앤드 캄파니 | 키나제 억제제로서의 퓨린 유도체 |
| JP4845379B2 (ja) | 2002-09-19 | 2011-12-28 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン |
| EP1768679B1 (en) * | 2004-07-09 | 2012-08-22 | Agency for Science, Technology and Research | Modulation of gsk-3beta and method of treating proliferative disorders |
| GB0418328D0 (en) | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
| EP2460886B1 (en) * | 2005-05-04 | 2014-01-01 | University of South Florida | Predicting treatment response in cancer subjects |
| TWI428132B (zh) * | 2007-07-02 | 2014-03-01 | Lilly Co Eli | 癌症化療效果之強化 |
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| EP1788086A1 (en) * | 1997-03-17 | 2007-05-23 | Human Genome Sciences, Inc. | Death Domain Containing Receptor 5 |
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