EA017303B1 - Модифицированные гуманизированные антитела против интерлейкина-18 и их применение - Google Patents
Модифицированные гуманизированные антитела против интерлейкина-18 и их применение Download PDFInfo
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- EA017303B1 EA017303B1 EA200802182A EA200802182A EA017303B1 EA 017303 B1 EA017303 B1 EA 017303B1 EA 200802182 A EA200802182 A EA 200802182A EA 200802182 A EA200802182 A EA 200802182A EA 017303 B1 EA017303 B1 EA 017303B1
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- antibody
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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| GB0611046A GB0611046D0 (en) | 2006-06-05 | 2006-06-05 | Immunoglobulins |
| PCT/EP2007/055029 WO2007137984A2 (en) | 2006-05-25 | 2007-05-23 | Modified humanised anti-interleukin-18 antibodies |
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| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| CA2647846C (en) | 2006-03-31 | 2016-06-21 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| ES2514495T3 (es) | 2006-05-25 | 2014-10-28 | Glaxo Group Limited | Anticuerpos humanizados modificados anti-interleucina-18 |
| CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR102339457B1 (ko) | 2007-09-26 | 2021-12-14 | 추가이 세이야쿠 가부시키가이샤 | 항체 정상영역 개변체 |
| CA2721052C (en) | 2008-04-11 | 2023-02-21 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| EP2326315A1 (en) * | 2008-08-18 | 2011-06-01 | Glaxo Group Limited | Treatment of an autoimmune disease using il-18 antagonists |
| EP2966434B1 (en) | 2008-08-27 | 2019-01-02 | F. Hoffmann-La Roche AG | Method to screen high affinity antibody |
| TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| WO2010040736A2 (en) * | 2008-10-07 | 2010-04-15 | Ablynx Nv | Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling |
| US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| WO2010107109A1 (ja) | 2009-03-19 | 2010-09-23 | 中外製薬株式会社 | 抗体定常領域改変体 |
| WO2011023623A1 (en) | 2009-08-25 | 2011-03-03 | F. Hoffmann-La Roche Ag | Velocity factor |
| US20120308564A1 (en) * | 2010-02-09 | 2012-12-06 | Andrew Ian Bayliffe | Treatment of a metabolic disorder |
| SG184473A1 (en) | 2010-04-07 | 2012-11-29 | Abbvie Inc | Tnf-alpha binding proteins |
| US8916695B2 (en) * | 2010-11-23 | 2014-12-23 | Glaxo Group Limited | Antigen binding proteins to oncostatin M (OSM) |
| BR112013013354A2 (pt) | 2010-11-30 | 2020-10-06 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno capaz de se ligar a uma pluralidade de moléculas de antígeno repetidamente |
| US20130149308A1 (en) * | 2011-08-12 | 2013-06-13 | Genentech, Inc. | Antibodies to il-1beta and il-18, for treatment of disease |
| JOP20200308A1 (ar) | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| ES2742413T3 (es) | 2012-11-21 | 2020-02-14 | Km Biologics Co Ltd | Nuevo anticuerpo humano contra IL-18 |
| WO2014186350A1 (en) * | 2013-05-15 | 2014-11-20 | Medimmune Limited | Purification of recombinantly produced polypeptides |
| JP6442404B2 (ja) | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | 再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法 |
| RU2730590C2 (ru) | 2015-02-27 | 2020-08-24 | Чугаи Сейяку Кабусики Кайся | Композиция для лечения заболеваний, связанных с ил-6 |
| ES2888801T3 (es) | 2015-05-19 | 2022-01-07 | Nat Center Neurology & Psychiatry | Método para determinar la aplicación de una terapia nueva en pacientes con esclerosis múltiple (EM) |
| WO2017076805A1 (en) * | 2015-11-02 | 2017-05-11 | Glaxosmithkline Intellectual Property Development Limited | Use of an inhibitor of il18 for treatment of acute kidney injury |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| US11324750B2 (en) | 2020-04-09 | 2022-05-10 | Children's Hospital Medical Center | Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection |
| WO2021206766A1 (en) | 2020-04-09 | 2021-10-14 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| EP3892280A3 (en) | 2020-04-09 | 2022-01-12 | Children's Hospital Medical Center | Sars-cov-2 infection biomarkers and uses thereof |
| TW202233237A (zh) | 2020-11-18 | 2022-09-01 | 瑞士商諾華公司 | 用於在治療ｎｌｒｃ４－ｇｏｆ炎性體病變中使用的雙特異性抗體 |
| EP4371573A4 (en) | 2021-07-13 | 2025-08-20 | National Univ Corporation Tokai National Higher Education And Research System | MEDICINAL COMPOSITION FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE |
| WO2023056193A2 (en) * | 2021-09-29 | 2023-04-06 | Chimera Bioengineering, Inc. | Il-18 variants and uses thereof |
| WO2024261470A1 (en) | 2023-06-20 | 2024-12-26 | Apollo Ap43 Limited | Anti-il-18 antibody therapy for treating atopic dermatitis |
| WO2025229563A1 (en) * | 2024-05-03 | 2025-11-06 | Glaxosmithkline Intellectual Property Development Limited | Methods of treating inflammatory bowel disease |
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| EP2326315A1 (en) | 2008-08-18 | 2011-06-01 | Glaxo Group Limited | Treatment of an autoimmune disease using il-18 antagonists |
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2018
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| WO2000056771A1 (en) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Corporation | Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders |
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