EA013371B1 - Новые соединения, содержащие их фармацевтические композиции и способы их применения - Google Patents
Новые соединения, содержащие их фармацевтические композиции и способы их применения Download PDFInfo
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- EA013371B1 EA013371B1 EA200500178A EA200500178A EA013371B1 EA 013371 B1 EA013371 B1 EA 013371B1 EA 200500178 A EA200500178 A EA 200500178A EA 200500178 A EA200500178 A EA 200500178A EA 013371 B1 EA013371 B1 EA 013371B1
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- Eurasian Patent Office
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39458502P | 2002-07-09 | 2002-07-09 | |
| PCT/US2003/021700 WO2004005277A1 (en) | 2002-07-09 | 2003-07-09 | Novel compunds, pharmaceutical compositions containing same, and methods of use for same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200500178A1 EA200500178A1 (ru) | 2006-02-24 |
| EA013371B1 true EA013371B1 (ru) | 2010-04-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA200500178A EA013371B1 (ru) | 2002-07-09 | 2003-07-09 | Новые соединения, содержащие их фармацевтические композиции и способы их применения |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7649012B2 (https=) |
| EP (3) | EP2386551A1 (https=) |
| JP (3) | JP2005533835A (https=) |
| KR (1) | KR101087559B1 (https=) |
| CN (2) | CN100513404C (https=) |
| AU (1) | AU2003265267B2 (https=) |
| BR (1) | BRPI0312649A2 (https=) |
| CA (2) | CA2767092C (https=) |
| EA (1) | EA013371B1 (https=) |
| IL (2) | IL166108A0 (https=) |
| MX (1) | MXPA05000365A (https=) |
| SG (1) | SG169236A1 (https=) |
| WO (1) | WO2004005277A1 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1471906A4 (en) | 2002-02-08 | 2006-02-01 | Univ Johns Hopkins Med | STIMULATION OF CPT-1 TO REDUCE BODY WEIGHT |
| JP4493494B2 (ja) * | 2002-07-09 | 2010-06-30 | ファスゲン，インク． | ヒトおよび動物における微生物感染症の治療方法 |
| EP2386551A1 (en) * | 2002-07-09 | 2011-11-16 | Fasgen Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| CN101022792A (zh) * | 2004-05-26 | 2007-08-22 | 法斯根有限责任公司 | 新化合物、包含该化合物的药物组合物及该化合物的应用方法 |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| JP2010509335A (ja) * | 2006-11-08 | 2010-03-25 | ファスゲン エルエルシー | 新規の化合物、それを含有する医薬組成物、及びその使用方法 |
| WO2008059214A1 (en) * | 2006-11-13 | 2008-05-22 | Astrazeneca Ab | Bisamlde derivatives and use thereof as fatty acid synthase inhibitors |
| WO2009149066A1 (en) * | 2008-06-02 | 2009-12-10 | Fasgen, Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| WO2010118324A2 (en) | 2009-04-09 | 2010-10-14 | Nuclea Biotechnologies, LLC | Antibodies against fatty acid synthase |
| US9149445B2 (en) | 2009-07-27 | 2015-10-06 | The Trustees Of Princeton University | Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections |
| MX2012001729A (es) | 2009-08-26 | 2012-06-13 | Sanofi Sa | Nuevos hidratos cristalinos de fluoroglicosido heteroaromatico, productos farmaceuticos que comprenden estos compuestos, y su empleo. |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8895547B2 (en) | 2011-03-08 | 2014-11-25 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012135027A2 (en) * | 2011-03-25 | 2012-10-04 | The Research Foundation Of State University Of New York | Thiolactone antibiotics |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| AU2013280980B2 (en) | 2012-06-25 | 2017-10-19 | Thomas Jefferson University | Compositions and methods for treating cancer with aberrant lipogenic signaling |
| JP6285442B2 (ja) * | 2012-09-07 | 2018-02-28 | ヤンセン ファーマシューティカ エヌ．ベー． | がん治療用の脂肪酸合成酵素（ｆａｓｎ）阻害剤として有用なイミダゾリン−５−オン誘導体 |
| SG10201707409PA (en) | 2013-03-13 | 2017-10-30 | Forma Therapeutics Inc | Novel compounds and compositions for inhibition of fasn |
| WO2016079317A1 (en) | 2014-11-20 | 2016-05-26 | Vib Vzw | Means and methods for treatment of early-onset parkinson's disease |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| CN114480521B (zh) * | 2020-11-13 | 2024-07-26 | 中国科学院青岛生物能源与过程研究所 | 一种三氮菌素c的制备方法 |
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| SU1512481A3 (ru) * | 1986-09-24 | 1989-09-30 | Лонца Аг (Фирма) | Способ получени тиотетроновой кислоты |
| US6376682B1 (en) * | 2000-02-01 | 2002-04-23 | Takama System, Ltd. | Compound with α-glucosidase inhibiting action and method for producing the same |
| US6380214B1 (en) * | 1999-05-19 | 2002-04-30 | Pfizer Inc. | Heterocyclic derivatives useful as anticancer agents |
| US6391912B1 (en) * | 1996-12-12 | 2002-05-21 | Bayer Aktiengesellschaft | Substituted phenylketoenols |
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| US3496187A (en) * | 1967-03-20 | 1970-02-17 | American Home Prod | N-(heterocyclyl)aconamides |
| US3472878A (en) * | 1969-01-27 | 1969-10-14 | American Home Prod | N-(hydroxyaryl)aconamides |
| JPS5859920A (ja) * | 1981-10-05 | 1983-04-09 | Chugai Pharmaceut Co Ltd | 生体防禦能賦活剤 |
| US4565699A (en) * | 1983-07-18 | 1986-01-21 | The Upjohn Company | Composition of matter and process |
| US4720503A (en) * | 1985-08-02 | 1988-01-19 | Merck & Co., Inc. | N-substituted fused-heterocyclic carboxamide derivatives as dual cyclooxygenase and lipoxygenase inhibitors |
| US4753871A (en) * | 1986-12-12 | 1988-06-28 | Eastman Kodak Company | Cyan dye-forming couplers and photographic materials containing same |
| AU1044088A (en) * | 1986-12-17 | 1988-07-15 | Nippon Soda Co., Ltd. | Heterocyclic compounds having triketo skeleton |
| US5665874A (en) * | 1989-01-17 | 1997-09-09 | John Hopkins University | Cancer related antigen |
| US5759837A (en) | 1989-01-17 | 1998-06-02 | John Hopkins University | Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway |
| US5759791A (en) * | 1989-01-17 | 1998-06-02 | The Johns Hopkins University | Cancer related antigen |
| US5679801A (en) * | 1991-04-12 | 1997-10-21 | American Home Products Corporation | Tetronic and thiotetronic acid derivatives as phospholipase A2 inhibitors |
| US5614551A (en) | 1994-01-24 | 1997-03-25 | The Johns Hopkins University | Inhibitors of fatty acid synthesis as antimicrobial agents |
| CN1131209C (zh) * | 1995-05-09 | 2003-12-17 | 拜尔公司 | 可用作杀虫剂和除草剂的烷基－二卤代苯基取代的酮烯醇 |
| US5981575A (en) | 1996-11-15 | 1999-11-09 | Johns Hopkins University, The | Inhibition of fatty acid synthase as a means to reduce adipocyte mass |
| JPH10212284A (ja) * | 1996-11-27 | 1998-08-11 | Sagami Chem Res Center | テトロン酸−３−カルボン酸誘導体、その製造方法、製造中間体、抗がん剤、及び蛋白脱リン酸化酵素阻害剤 |
| CO4970714A1 (es) * | 1997-09-05 | 2000-11-07 | Boehringer Mannheim Gmbh | Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales |
| IT1315267B1 (it) * | 1999-12-23 | 2003-02-03 | Novuspharma Spa | Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale |
| GB0000131D0 (en) * | 2000-01-06 | 2000-02-23 | Univ Cardiff | Thiolactomycin analogues,compositions containing the same and uses thereof |
| MY134040A (en) | 2001-05-02 | 2007-11-30 | Univ New York | Inhibition of pigmentation by inhibition of fatty acid synthase |
| EP1471906A4 (en) * | 2002-02-08 | 2006-02-01 | Univ Johns Hopkins Med | STIMULATION OF CPT-1 TO REDUCE BODY WEIGHT |
| EP2386551A1 (en) * | 2002-07-09 | 2011-11-16 | Fasgen Inc. | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| JP4493494B2 (ja) | 2002-07-09 | 2010-06-30 | ファスゲン，インク． | ヒトおよび動物における微生物感染症の治療方法 |
| US9690894B1 (en) | 2015-11-02 | 2017-06-27 | Altera Corporation | Safety features for high level design |
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2003
- 2003-07-09 EP EP11164126A patent/EP2386551A1/en not_active Withdrawn
- 2003-07-09 KR KR1020057000382A patent/KR101087559B1/ko not_active Expired - Fee Related
- 2003-07-09 SG SG200806632-6A patent/SG169236A1/en unknown
- 2003-07-09 MX MXPA05000365A patent/MXPA05000365A/es active IP Right Grant
- 2003-07-09 WO PCT/US2003/021700 patent/WO2004005277A1/en not_active Ceased
- 2003-07-09 JP JP2004520132A patent/JP2005533835A/ja active Pending
- 2003-07-09 EP EP11164123A patent/EP2386550A1/en not_active Withdrawn
- 2003-07-09 US US10/520,505 patent/US7649012B2/en not_active Expired - Fee Related
- 2003-07-09 EP EP03763470A patent/EP1539730A4/en not_active Withdrawn
- 2003-07-09 AU AU2003265267A patent/AU2003265267B2/en not_active Ceased
- 2003-07-09 EA EA200500178A patent/EA013371B1/ru not_active IP Right Cessation
- 2003-07-09 CN CNB038185563A patent/CN100513404C/zh not_active Expired - Fee Related
- 2003-07-09 CA CA2767092A patent/CA2767092C/en not_active Expired - Fee Related
- 2003-07-09 CA CA2491802A patent/CA2491802C/en not_active Expired - Fee Related
- 2003-07-09 CN CN200910203849.8A patent/CN101602756B/zh not_active Expired - Fee Related
- 2003-07-09 BR BRPI0312649A patent/BRPI0312649A2/pt not_active IP Right Cessation
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2005
- 2005-01-03 IL IL16610805A patent/IL166108A0/xx unknown
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2008
- 2008-03-17 IL IL190218A patent/IL190218A0/en unknown
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2010
- 2010-01-13 US US12/686,691 patent/US20100120901A1/en not_active Abandoned
- 2010-10-08 JP JP2010228956A patent/JP2011037881A/ja active Pending
-
2013
- 2013-06-04 JP JP2013117677A patent/JP2013189464A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1512481A3 (ru) * | 1986-09-24 | 1989-09-30 | Лонца Аг (Фирма) | Способ получени тиотетроновой кислоты |
| US6391912B1 (en) * | 1996-12-12 | 2002-05-21 | Bayer Aktiengesellschaft | Substituted phenylketoenols |
| US6380214B1 (en) * | 1999-05-19 | 2002-04-30 | Pfizer Inc. | Heterocyclic derivatives useful as anticancer agents |
| US6376682B1 (en) * | 2000-02-01 | 2002-04-23 | Takama System, Ltd. | Compound with α-glucosidase inhibiting action and method for producing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2767092C (en) | 2013-10-15 |
| JP2011037881A (ja) | 2011-02-24 |
| MXPA05000365A (es) | 2005-09-20 |
| BRPI0312649A2 (pt) | 2017-05-16 |
| HK1083835A1 (zh) | 2006-07-14 |
| IL166108A0 (en) | 2006-01-15 |
| SG169236A1 (en) | 2011-03-30 |
| US20060247302A1 (en) | 2006-11-02 |
| CA2767092A1 (en) | 2004-01-15 |
| CN100513404C (zh) | 2009-07-15 |
| CA2491802C (en) | 2012-04-10 |
| JP2005533835A (ja) | 2005-11-10 |
| KR20060002007A (ko) | 2006-01-06 |
| CN1675192A (zh) | 2005-09-28 |
| EP1539730A4 (en) | 2007-03-28 |
| WO2004005277A1 (en) | 2004-01-15 |
| KR101087559B1 (ko) | 2011-11-29 |
| CN101602756B (zh) | 2014-11-12 |
| JP2013189464A (ja) | 2013-09-26 |
| US7649012B2 (en) | 2010-01-19 |
| CN101602756A (zh) | 2009-12-16 |
| EP2386551A1 (en) | 2011-11-16 |
| EP1539730A1 (en) | 2005-06-15 |
| EP2386550A1 (en) | 2011-11-16 |
| IL190218A0 (en) | 2008-11-03 |
| CA2491802A1 (en) | 2004-01-15 |
| EA200500178A1 (ru) | 2006-02-24 |
| US20100120901A1 (en) | 2010-05-13 |
| AU2003265267B2 (en) | 2010-03-11 |
| AU2003265267A1 (en) | 2004-01-23 |
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