EA010246B1 - Активируемые частицы, их получение и применение - Google Patents

Активируемые частицы, их получение и применение Download PDF

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Publication number
EA010246B1
EA010246B1 EA200602077A EA200602077A EA010246B1 EA 010246 B1 EA010246 B1 EA 010246B1 EA 200602077 A EA200602077 A EA 200602077A EA 200602077 A EA200602077 A EA 200602077A EA 010246 B1 EA010246 B1 EA 010246B1
Authority
EA
Eurasian Patent Office
Prior art keywords
particle
aggregate
nanoparticles
particles
nanoparticles according
Prior art date
Application number
EA200602077A
Other languages
English (en)
Russian (ru)
Other versions
EA200602077A1 (ru
Inventor
Лоран Леви
Жан-Франсуа Ошпье
Жереми Баланси
Парас Нат Прасад
Эрл Джим Бёрджей
Эдуар Андре Панак
Абдель Кадер Буссаха
Original Assignee
Нанобиотикс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Нанобиотикс filed Critical Нанобиотикс
Publication of EA200602077A1 publication Critical patent/EA200602077A1/ru
Publication of EA010246B1 publication Critical patent/EA010246B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0423Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661Radiation therapy using light characterised by the wavelength of light used ultraviolet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092Details
    • A61N2005/1098Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paints Or Removers (AREA)
EA200602077A 2004-05-10 2005-05-09 Активируемые частицы, их получение и применение EA010246B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0405036A FR2869803B1 (fr) 2004-05-10 2004-05-10 Particules activables, preparation et utilisations
PCT/FR2005/001145 WO2005120590A1 (fr) 2004-05-10 2005-05-09 Particules activables, preparation et utilisations

Publications (2)

Publication Number Publication Date
EA200602077A1 EA200602077A1 (ru) 2007-04-27
EA010246B1 true EA010246B1 (ru) 2008-06-30

Family

ID=34945762

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200602077A EA010246B1 (ru) 2004-05-10 2005-05-09 Активируемые частицы, их получение и применение

Country Status (25)

Country Link
US (2) US9162079B2 (es)
EP (1) EP1744789B1 (es)
JP (1) JP5150251B2 (es)
KR (2) KR101234334B1 (es)
CN (1) CN100592921C (es)
AT (1) ATE403444T1 (es)
AU (1) AU2005251499B2 (es)
BR (1) BRPI0510290B8 (es)
CA (1) CA2564197C (es)
CY (1) CY1108369T1 (es)
DE (1) DE602005008731D1 (es)
DK (1) DK1744789T3 (es)
EA (1) EA010246B1 (es)
ES (1) ES2312004T3 (es)
FR (1) FR2869803B1 (es)
HK (1) HK1099508A1 (es)
HR (1) HRP20080534T3 (es)
IL (1) IL178877A (es)
MX (1) MXPA06013095A (es)
PL (1) PL1744789T3 (es)
PT (1) PT1744789E (es)
RS (1) RS50615B (es)
SI (1) SI1744789T1 (es)
WO (1) WO2005120590A1 (es)
ZA (1) ZA200610255B (es)

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FR2869803B1 (fr) 2004-05-10 2006-07-28 Nanobiotix Sarl Particules activables, preparation et utilisations
FR2877571B1 (fr) * 2004-11-05 2007-04-13 Nanobiotix Sarl Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations
NZ555534A (en) * 2004-11-15 2008-12-24 Australian Nuclear Science Tec Solid particles from controlled destabilisation of microemulsions
US20070218049A1 (en) * 2006-02-02 2007-09-20 Wei Chen Nanoparticle based photodynamic therapy and methods of making and using same
WO2007122956A1 (ja) * 2006-03-24 2007-11-01 Toto Ltd. 酸化チタン複合体粒子、その分散液、およびそれらの製造方法
EP1852107A1 (en) * 2006-04-19 2007-11-07 Nanobiotix Magnetic nanoparticles compositions and uses thereof
EP1920784A1 (en) * 2006-11-13 2008-05-14 Koninklijke Philips Electronics N.V. Radiation sensitizers in ionizing radiation therapy and imaging
US9488916B2 (en) * 2007-04-08 2016-11-08 Immunolight, Llc. Interior energy-activation of photo-reactive species inside a medium or body
US8376013B2 (en) 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
US9358292B2 (en) 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US9023249B2 (en) 2010-05-06 2015-05-05 Immunolight, Llc Adhesive bonding composition and method of use
FR2922106B1 (fr) * 2007-10-16 2011-07-01 Univ Claude Bernard Lyon Utilisation de nanoparticules a base de lanthanides comme agents radiosensibilisants.
US8164074B2 (en) * 2007-10-18 2012-04-24 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US8227204B2 (en) * 2007-10-18 2012-07-24 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US8529426B2 (en) * 2007-10-18 2013-09-10 The Invention Science Fund I Llc Ionizing-radiation-responsive compositions, methods, and systems
US8684898B2 (en) * 2007-10-18 2014-04-01 The Invention Science Fund I Llc Ionizing-radiation-responsive compositions, methods, and systems
US20090104113A1 (en) * 2007-10-18 2009-04-23 Searete Llc Ionizing-radiation-responsive compositions, methods, and systems
GB2453860B (en) * 2007-10-18 2011-03-16 Searete Llc Ionizing-radiation-responsive compositions,methods and systems
US8168958B2 (en) * 2007-10-18 2012-05-01 The Invention Science Fund I, Llc Ionizing-radiation-responsive compositions, methods, and systems
US9557635B2 (en) * 2007-10-18 2017-01-31 Gearbox, Llc Ionizing-radiation-responsive compositions, methods, and systems
WO2009105662A1 (en) 2008-02-21 2009-08-27 Immunolight, Llc. Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (pepst) and exciton-plasmon enhanced phototherapy (epep)
CA2720513C (en) * 2008-04-04 2018-09-25 Immunolight, Llc Non-invasive systems and methods for in-situ photobiomodulation
EP2130553A1 (en) * 2008-06-05 2009-12-09 Nanobiotix Inorganic nanoparticles of high density to destroy cells in-vivo
WO2010009106A1 (en) * 2008-07-14 2010-01-21 Bourke Frederic A Jr Advanced methods and systems for treating cell proliferation disorders
WO2010013136A2 (en) 2008-07-31 2010-02-04 Alma Mater Studiorum - Universita' Di Bologna Active particles for bio-analytical applications and methods for their preparation
EP2421376A4 (en) * 2009-04-21 2016-04-27 Immunolight Llc NON-INVASIVE ENERGY UPGRADING METHODS AND SYSTEMS FOR IN-SITU PHOTO BODY MODULATION
CN107149689A (zh) * 2009-11-10 2017-09-12 免疫之光有限责任公司 对可辐射固化介质进行固化的系统和产生光的方法
GB0921596D0 (en) 2009-12-09 2010-01-27 Isis Innovation Particles for the treatment of cancer in combination with radiotherapy
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
WO2012027728A2 (en) 2010-08-27 2012-03-01 Sienna Labs, Inc. Compositions and methods for targeted thermomodulation
US9116246B2 (en) * 2011-04-07 2015-08-25 Stc.Unm Thermal neutron detectors based on gadolinium-containing nanoscintillators
WO2012153820A1 (ja) * 2011-05-12 2012-11-15 コニカミノルタエムジー株式会社 X線吸収蛍光ナノ粒子
EP3494974B1 (en) 2011-07-08 2023-10-18 The University of North Carolina at Chapel Hill Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders
EP2729175B1 (en) * 2011-07-08 2021-12-01 Duke University System for light stimulation within a medium
WO2013035739A1 (ja) * 2011-09-05 2013-03-14 株式会社Ihi 温熱治療用材料、温熱治療用システム及び温熱治療方法
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US10780164B2 (en) * 2014-04-03 2020-09-22 The Governing Council Of The University Of Toronto Multifunctional nanoparticle compositions and uses thereof
US10806694B2 (en) 2014-10-14 2020-10-20 The University Of Chicago Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof
WO2016061256A1 (en) 2014-10-14 2016-04-21 The University Of Chicago Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof
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US9770688B2 (en) * 2015-10-22 2017-09-26 King Fahd University Of Petroleum And Minerals Si—Y nanocomposite membrane and methods of making and use thereof
JP7090034B2 (ja) 2016-05-20 2022-06-23 ザ ユニバーシティ オブ シカゴ 化学療法、標的療法、光線力学療法、免疫療法及びそれらの任意の組み合わせのためのナノ粒子
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Also Published As

Publication number Publication date
BRPI0510290A (pt) 2007-10-30
CA2564197A1 (fr) 2005-12-22
BRPI0510290B1 (pt) 2021-06-01
RS50615B (sr) 2010-06-30
WO2005120590A1 (fr) 2005-12-22
CN1950111A (zh) 2007-04-18
DK1744789T3 (da) 2008-12-08
IL178877A (en) 2010-12-30
HK1099508A1 (en) 2007-08-17
HRP20080534T3 (en) 2008-11-30
US9162079B2 (en) 2015-10-20
DE602005008731D1 (de) 2008-09-18
FR2869803B1 (fr) 2006-07-28
BRPI0510290B8 (pt) 2021-10-19
CN100592921C (zh) 2010-03-03
US20070217996A1 (en) 2007-09-20
CY1108369T1 (el) 2014-02-12
AU2005251499A1 (en) 2005-12-22
CA2564197C (fr) 2013-05-07
US20150238775A1 (en) 2015-08-27
KR101234334B1 (ko) 2013-02-18
FR2869803A1 (fr) 2005-11-11
SI1744789T1 (sl) 2008-10-31
KR20070014172A (ko) 2007-01-31
IL178877A0 (en) 2007-03-08
KR20120123731A (ko) 2012-11-09
PL1744789T3 (pl) 2009-01-30
ZA200610255B (en) 2008-09-25
EA200602077A1 (ru) 2007-04-27
JP5150251B2 (ja) 2013-02-20
US9433800B2 (en) 2016-09-06
AU2005251499B2 (en) 2010-06-10
ES2312004T3 (es) 2009-02-16
MXPA06013095A (es) 2007-04-27
EP1744789A1 (fr) 2007-01-24
JP2007536356A (ja) 2007-12-13
EP1744789B1 (fr) 2008-08-06
PT1744789E (pt) 2008-11-04
BRPI0510290A8 (pt) 2019-01-02
ATE403444T1 (de) 2008-08-15

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