EA009068B1 - Ингаляционная композиция в виде раствора с солью тиотропия - Google Patents
Ингаляционная композиция в виде раствора с солью тиотропия Download PDFInfo
- Publication number
- EA009068B1 EA009068B1 EA200300483A EA200300483A EA009068B1 EA 009068 B1 EA009068 B1 EA 009068B1 EA 200300483 A EA200300483 A EA 200300483A EA 200300483 A EA200300483 A EA 200300483A EA 009068 B1 EA009068 B1 EA 009068B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- composition according
- drug composition
- tiotropium
- active substance
- inhaler
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 124
- LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical class O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 title claims description 38
- 238000009472 formulation Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 50
- LERNTVKEWCAPOY-VOGVJGKGSA-N C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 Chemical compound C[N+]1(C)[C@H]2C[C@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 LERNTVKEWCAPOY-VOGVJGKGSA-N 0.000 claims abstract description 27
- 229960000257 tiotropium bromide Drugs 0.000 claims abstract description 27
- 239000000443 aerosol Substances 0.000 claims abstract description 23
- MQLXPRBEAHBZTK-SEINRUQRSA-M tiotropium bromide hydrate Chemical compound O.[Br-].C[N+]1(C)[C@H]2C[C@@H](C[C@@H]1[C@H]1O[C@@H]21)OC(=O)C(O)(c1cccs1)c1cccs1 MQLXPRBEAHBZTK-SEINRUQRSA-M 0.000 claims abstract description 13
- 239000003814 drug Substances 0.000 claims description 46
- 229940079593 drug Drugs 0.000 claims description 44
- 239000013543 active substance Substances 0.000 claims description 40
- 239000007921 spray Substances 0.000 claims description 27
- -1 3- (2- (6,7-difluoro-2quinolinyl) ethenyl) phenyl Chemical group 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 22
- 229940110309 tiotropium Drugs 0.000 claims description 19
- 150000003839 salts Chemical group 0.000 claims description 16
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical group [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 15
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- 229940037001 sodium edetate Drugs 0.000 claims description 15
- 150000003431 steroids Chemical class 0.000 claims description 15
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims description 14
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- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 6
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- 229960004398 nedocromil Drugs 0.000 claims description 3
- RQTOOFIXOKYGAN-UHFFFAOYSA-N nedocromil Chemical compound CCN1C(C(O)=O)=CC(=O)C2=C1C(CCC)=C1OC(C(O)=O)=CC(=O)C1=C2 RQTOOFIXOKYGAN-UHFFFAOYSA-N 0.000 claims description 3
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- UAJUXJSXCLUTNU-UHFFFAOYSA-N pranlukast Chemical compound C=1C=C(OCCCCC=2C=CC=CC=2)C=CC=1C(=O)NC(C=1)=CC=C(C(C=2)=O)C=1OC=2C=1N=NNN=1 UAJUXJSXCLUTNU-UHFFFAOYSA-N 0.000 claims description 3
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- HRIQUAYTZYHSJP-UHFFFAOYSA-N 2-[2-[[2-(4-tert-butyl-1,3-thiazol-2-yl)-1-benzofuran-5-yl]-hydroxymethyl]phenyl]acetic acid Chemical compound C(C)(C)(C)C=1N=C(SC1)C=1OC2=C(C1)C=C(C=C2)C(C2=C(C=CC=C2)CC(=O)O)O HRIQUAYTZYHSJP-UHFFFAOYSA-N 0.000 claims description 2
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10054042 | 2000-10-31 | ||
| PCT/EP2001/012296 WO2002036591A2 (de) | 2000-10-31 | 2001-10-24 | Inhalative lösungsformulierung mit einem tiotropiumsalz |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200300483A1 EA200300483A1 (ru) | 2003-12-25 |
| EA009068B1 true EA009068B1 (ru) | 2007-10-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA200300483A EA009068B1 (ru) | 2000-10-31 | 2001-10-24 | Ингаляционная композиция в виде раствора с солью тиотропия |
Country Status (33)
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| EP (1) | EP1335729A2 (bg) |
| JP (1) | JP4559703B2 (bg) |
| KR (1) | KR100983208B1 (bg) |
| CN (1) | CN1237970C (bg) |
| AR (1) | AR038765A1 (bg) |
| AU (2) | AU2002221741B2 (bg) |
| BG (1) | BG66425B1 (bg) |
| BR (1) | BR0115016A (bg) |
| CA (1) | CA2427583C (bg) |
| CZ (1) | CZ305033B6 (bg) |
| DE (1) | DE10152369A1 (bg) |
| EA (1) | EA009068B1 (bg) |
| EC (1) | ECSP034570A (bg) |
| EE (1) | EE05343B1 (bg) |
| HK (1) | HK1060569A1 (bg) |
| HR (1) | HRP20030337A2 (bg) |
| HU (1) | HUP0301377A3 (bg) |
| IL (2) | IL155676A0 (bg) |
| ME (1) | ME00242B (bg) |
| MX (1) | MXPA03003750A (bg) |
| MY (1) | MY132777A (bg) |
| NO (1) | NO332524B1 (bg) |
| NZ (1) | NZ526024A (bg) |
| PE (1) | PE20020518A1 (bg) |
| PL (1) | PL361001A1 (bg) |
| SA (1) | SA01220503B1 (bg) |
| SK (1) | SK288031B6 (bg) |
| TW (1) | TWI296934B (bg) |
| UA (1) | UA76435C2 (bg) |
| UY (1) | UY26991A1 (bg) |
| WO (1) | WO2002036591A2 (bg) |
| YU (1) | YU33103A (bg) |
| ZA (1) | ZA200303045B (bg) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60114865T2 (de) | 2000-04-28 | 2006-07-27 | Kosan Biosciences, Inc., Hayward | Heterologe herstellung von polyketiden |
| US20030235538A1 (en) | 2002-04-09 | 2003-12-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for the administration of an anticholinergic by inhalation |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| CA2544611A1 (en) * | 2003-10-09 | 2005-04-21 | Inverseon, Inc. | Method of treating airway diseases with beta-adrenergic inverse agonists |
| SE0303269L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Medicinsk produkt |
| MX2007011273A (es) * | 2005-03-16 | 2007-11-08 | Meda Pharma Gmbh & Co Kg | La combinacion de anticolinergicos y antagonistas del receptor de leucotrieno para el tratamiento de enfermedades respiratorias. |
| WO2007140285A2 (en) * | 2006-05-26 | 2007-12-06 | Dey, L.P. | Nebulizable compositions of quaternary ammonium muscarinic receptor antagonists |
| CN100446770C (zh) * | 2007-01-10 | 2008-12-31 | 上海现代药物制剂工程研究中心有限公司 | 丙酸培氯米松水雾剂 |
| TR200907237A2 (tr) * | 2009-09-23 | 2011-04-21 | Bi̇lgi̇ç Mahmut | Tiotropyum kuru toz kombinasyonu |
| CN116196298A (zh) * | 2018-07-26 | 2023-06-02 | 四川海思科制药有限公司 | 一种含格隆铵盐的气雾剂药物组合物及其制备方法与应用 |
| CN111936124A (zh) * | 2018-07-26 | 2020-11-13 | 四川海思科制药有限公司 | 一种含格隆铵盐及茚达特罗盐的气雾剂药物组合物及其制备方法与应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0504112A2 (de) * | 1991-03-14 | 1992-09-16 | Ciba-Geigy Ag | Pharmazeutische Aerosolformulierungen |
| DE4203306A1 (de) * | 1992-02-06 | 1993-08-12 | Ig Spruehtechnik Gmbh | Asthma oder pulmonal-aerosolzubereitungen mit lecithin |
| WO1997046243A1 (en) * | 1996-06-04 | 1997-12-11 | The Procter & Gamble Company | A nasal spray containing an intranasal steroid and an antihistamine |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| JPH10298107A (ja) * | 1997-04-25 | 1998-11-10 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| WO2000007567A1 (de) * | 1998-08-04 | 2000-02-17 | Jago Research Ag | Medizinische aerosolformulierungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2223750C2 (ru) * | 1995-06-27 | 2004-02-20 | Берингер Ингельхайм КГ | Лекарственная композиция в виде раствора, предназначенная для получения способного к ингаляции аэрозоля |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| DE19847968A1 (de) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen |
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- 2001-10-24 EP EP01992710A patent/EP1335729A2/de not_active Ceased
- 2001-10-24 YU YU33103A patent/YU33103A/sh unknown
- 2001-10-24 CN CNB018183271A patent/CN1237970C/zh not_active Expired - Lifetime
- 2001-10-24 MX MXPA03003750A patent/MXPA03003750A/es active IP Right Grant
- 2001-10-24 HU HU0301377A patent/HUP0301377A3/hu unknown
- 2001-10-24 KR KR1020037006001A patent/KR100983208B1/ko active IP Right Grant
- 2001-10-24 PL PL01361001A patent/PL361001A1/xx not_active Application Discontinuation
- 2001-10-24 SK SK526-2003A patent/SK288031B6/sk not_active IP Right Cessation
- 2001-10-24 EE EEP200300202A patent/EE05343B1/xx unknown
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- 2001-10-24 WO PCT/EP2001/012296 patent/WO2002036591A2/de active IP Right Grant
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- 2001-10-24 AU AU2174102A patent/AU2174102A/xx active Pending
- 2001-10-24 DE DE10152369A patent/DE10152369A1/de not_active Withdrawn
- 2001-10-29 TW TW090126752A patent/TWI296934B/zh not_active IP Right Cessation
- 2001-10-29 UY UY26991A patent/UY26991A1/es not_active Application Discontinuation
- 2001-10-29 PE PE2001001072A patent/PE20020518A1/es active IP Right Grant
- 2001-10-29 MY MYPI20014987A patent/MY132777A/en unknown
- 2001-10-31 AR ARP010105088A patent/AR038765A1/es not_active Ceased/Invalidation/Refusal/Rejection/Nullification
- 2001-11-03 SA SA01220503A patent/SA01220503B1/ar unknown
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2003
- 2003-04-16 BG BG107726A patent/BG66425B1/bg active Active
- 2003-04-17 ZA ZA200303045A patent/ZA200303045B/xx unknown
- 2003-04-28 HR HR20030337A patent/HRP20030337A2/hr not_active Application Discontinuation
- 2003-04-28 EC EC2003004570A patent/ECSP034570A/es unknown
- 2003-04-29 NO NO20031914A patent/NO332524B1/no not_active IP Right Cessation
- 2003-04-30 IL IL155676A patent/IL155676A/en active IP Right Grant
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- 2004-05-20 HK HK04103587A patent/HK1060569A1/xx not_active IP Right Cessation
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| EP0504112A2 (de) * | 1991-03-14 | 1992-09-16 | Ciba-Geigy Ag | Pharmazeutische Aerosolformulierungen |
| DE4203306A1 (de) * | 1992-02-06 | 1993-08-12 | Ig Spruehtechnik Gmbh | Asthma oder pulmonal-aerosolzubereitungen mit lecithin |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| WO1997046243A1 (en) * | 1996-06-04 | 1997-12-11 | The Procter & Gamble Company | A nasal spray containing an intranasal steroid and an antihistamine |
| JPH10298107A (ja) * | 1997-04-25 | 1998-11-10 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| WO2000007567A1 (de) * | 1998-08-04 | 2000-02-17 | Jago Research Ag | Medizinische aerosolformulierungen |
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| BALZANO G. ET AL.: "Effectiveness and acceptability of a domiciliary multidrug inhalation treatment in elderly patients. with chronic airflow obstruction: metered dose inhaler versus jet nebulizer", JOURNAL OF AEROSOL MEDICINE: THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE. UNITED STATES 2000 SPRING, vol. 13, no. 1, April 2000 (2000-04), pages 25-33, XP001078735, ISSN: 0894-2684, page 26, column 2, paragraph 1 page 26, column 2, paragraph 3 page 27, column 2, paragraph 2 * |
| MON F. ET AL.: "AEROSOL THERAPY IN ASTHMA", REVUE DES MALADIES RESPIRATOIRES, vol. 6, no. 3, 1989, pages 189-200, XP001078722, ISSN: 0761-8425, Tab. IV page 196, Tab. V page 197 page 196, column 2, line 25 page 197, column 2 * |
| NACLERIO R.M.: "Optimizing treatment options." CLINICAL AND EXPERIMENTAL ALLERGY, vol. 28, no. SUPPL. 6, December 1998 (1998-12), pages 54-59, XP001078789, ISSN: 0954-7894, page 55, column 2, paragraph 1 page 55, column 2, paragraph 3 page 56, column 1 - column 2, paragraph 1 letzter Satz page 56, column 2, paragraph 3 page- 55, column 2 Absatz ??ber Spalter 1 und 2 hinweg, page 56 * |
| NISHIMURA KOICHI ET AL.: "Additive effect of oxitropium bromide in combination with inhaled corticosteroids in the treatment of elderly patients with chronic asthma". ALLERGOLOGY INTERNATIONAL, vol. 48, no. 1, March 1999 (1999-03), pages 85-88, XP001070756, ISSN: 1323-8930, "Discussion", page 87, column 1, "Abstract", page 85, column 1, "Study protocol", page 85, column 1, "Results", page 86, column 2 * |
| PATENT ABSTRACTS OF JAPAN, vol. 1999, no. 02, 26 February 1999 (1999-02-26) & JP 10 298107 A (TAISHO PHARMACEUT CO LTD.), 10 November 1998 (1998-11-10), abstract * |
| PAVIA D. ET AL.: "Preliminary data from phase II studies with Respimat, a propellant-free soft mist inhaler", JOURNAL OF AEROSOL MEDICINE: THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY FOR AEROSOLS IN MEDICINE. UNITED STATES 1999, vol. 12 Suppl 1, 1999, pages S33-S39, XP001078739, ISSN: 0894-2684, page 34, column 1, paragraph 2 page 35, column 2, line 2 page 36, column 2, paragraph 2 page 37, column 1, paragraph 2 * |
| RUTGERS S.R. ET AL.: "Short-term treatment with budesonide does not improve hyperresponsiveness to adenosine 5'-monophosphate in COPD", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. UNITED STATES MAR 1998, vol. 157, no. 3, Pt. 1, March 1998 (1998-03), pages 880-886, XP001078742, ISSN: 1073-449X, page 881, column 1, paragraph 1 page 885, column 1, paragraph 5 -column 2, paragraph 1 page 881; figure 1 * |
| VAN SCHAYCK C.P. ET AL.: "Periodic treatment regimens with inhaled steroids in asthma or chronic obstructive pulmonary disease. Is it possible?", JAMA: THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. UNITED STATES 12 JUL 1995, vol. 274, no. 2, 12 July 1995 (1995-07-12), pages 161-164, XP001078744, ISSN: 0098-7484, "Interventions", page 161, column 1 * |
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|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
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| MK4A | Patent expired |
Designated state(s): BY RU |