EA008835B1 - Замещенные сульфоны и сульфонамиды и фармацевтические композиции на их основе, применимые для лечения ожирения, сахарного диабета ii типа и расстройств центральной нервной системы - Google Patents
Замещенные сульфоны и сульфонамиды и фармацевтические композиции на их основе, применимые для лечения ожирения, сахарного диабета ii типа и расстройств центральной нервной системы Download PDFInfo
- Publication number
- EA008835B1 EA008835B1 EA200500054A EA200500054A EA008835B1 EA 008835 B1 EA008835 B1 EA 008835B1 EA 200500054 A EA200500054 A EA 200500054A EA 200500054 A EA200500054 A EA 200500054A EA 008835 B1 EA008835 B1 EA 008835B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- hydrochloride
- piperazin
- tert
- mmol
- sulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0201925A SE0201925D0 (sv) | 2002-06-20 | 2002-06-20 | New compounds |
SE0202181A SE0202181D0 (sv) | 2002-07-11 | 2002-07-11 | New compounds |
US40612002P | 2002-08-26 | 2002-08-26 | |
SE0202908A SE0202908D0 (sv) | 2002-10-01 | 2002-10-01 | New compounds |
US43401002P | 2002-12-17 | 2002-12-17 | |
SE0300357A SE0300357D0 (sv) | 2003-02-10 | 2003-02-10 | New compounds |
US46470103P | 2003-04-23 | 2003-04-23 | |
PCT/SE2003/001061 WO2004000828A1 (en) | 2002-06-20 | 2003-06-19 | New compounds useful for the treatment of obesity, type ii diabetes and cns disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200500054A1 EA200500054A1 (ru) | 2005-06-30 |
EA008835B1 true EA008835B1 (ru) | 2007-08-31 |
Family
ID=30004107
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600975A EA011581B1 (ru) | 2002-06-20 | 2003-06-19 | Конденсированные гетероциклические соединения, применимые для лечения ожирения и расстройств центральной нервной системы |
EA200500054A EA008835B1 (ru) | 2002-06-20 | 2003-06-19 | Замещенные сульфоны и сульфонамиды и фармацевтические композиции на их основе, применимые для лечения ожирения, сахарного диабета ii типа и расстройств центральной нервной системы |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600975A EA011581B1 (ru) | 2002-06-20 | 2003-06-19 | Конденсированные гетероциклические соединения, применимые для лечения ожирения и расстройств центральной нервной системы |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1513828A1 (sr) |
CN (1) | CN1662521A (sr) |
AU (1) | AU2003243091A1 (sr) |
BR (1) | BR0311952A (sr) |
CA (1) | CA2486989A1 (sr) |
EA (2) | EA011581B1 (sr) |
IL (1) | IL165051A0 (sr) |
MX (1) | MXPA04012914A (sr) |
NO (1) | NO20050294L (sr) |
NZ (3) | NZ536600A (sr) |
RS (1) | RS111204A (sr) |
SG (1) | SG156524A1 (sr) |
WO (1) | WO2004000828A1 (sr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2307919T3 (es) | 2002-03-27 | 2008-12-01 | Glaxo Group Limited | Derivados de quinolina y su uso como ligandos de 5-ht6. |
SE0301446D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | New Compounds |
TWI328009B (en) | 2003-05-21 | 2010-08-01 | Glaxo Group Ltd | Quinoline derivatives as phosphodiesterase inhibitors |
PT1558582E (pt) | 2003-07-22 | 2006-05-31 | Arena Pharm Inc | Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo |
SE0302760D0 (sv) * | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
BRPI0417833A (pt) * | 2003-12-19 | 2007-04-17 | Biovitrum Ab | novos derivados de benzofurano, os quais podem ser usados na profilaxia ou tratamento de distúrbios relacionados com o receptor 5-ht6 |
SE0303480D0 (sv) | 2003-12-19 | 2003-12-19 | Biovitrum Ab | Benzofuranes |
GB0407025D0 (en) * | 2004-03-29 | 2004-04-28 | Glaxo Group Ltd | Novel compounds |
TWI380816B (zh) * | 2004-04-13 | 2013-01-01 | Synta Pharmaceuticals Corp | 抑制介白素-12(il-12)生成之二鹽抑制劑 |
WO2006062481A1 (en) * | 2004-12-09 | 2006-06-15 | Biovitrum Ab | New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders . |
AR054044A1 (es) * | 2005-05-23 | 2007-05-30 | Astrazeneca Ab | Derivados de cromano y tetrahidronaftaleno como moduladores del receptor 5 - ht6; intermediarios en su preparacion; composiciones farmaceuticas que los contienen y su empelo en la fabricacion de medicamentos para el tratamiento de enfermedades del snc y de la obesidad. |
US7582767B2 (en) | 2005-06-17 | 2009-09-01 | Biovitrum Ab (Publ.) | Substituted sulphonamide compound and uses thereof |
EP1907384A2 (en) * | 2005-06-30 | 2008-04-09 | Prosidion Limited | Gpcr agonists |
KR20140033237A (ko) | 2005-10-07 | 2014-03-17 | 엑셀리시스, 인코포레이티드 | 포스파티딜이노시톨 3-키나아제 억제제 및 이의 사용 방법 |
WO2007051735A1 (en) | 2005-11-03 | 2007-05-10 | F. Hoffmann-La Roche Ag | Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors |
UY30048A1 (es) | 2005-12-23 | 2007-07-31 | Astrazeneca Ab | Derivados sustituidos de la n,2-(1h-benzimidazol-1-il) acetamida, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
CA2654822A1 (en) | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
CN101472884A (zh) | 2006-06-20 | 2009-07-01 | 弗·哈夫曼-拉罗切有限公司 | 1,2,3,4-四氢化萘和茚满衍生物及其用途 |
JP2009541248A (ja) | 2006-06-20 | 2009-11-26 | エフ.ホフマン−ラ ロシュ アーゲー | アリールスルホンアミジルテトラリン誘導体及びそれらの使用 |
TWI433839B (zh) | 2006-08-11 | 2014-04-11 | Neomed Inst | 新穎的苯并咪唑衍生物290 |
EP2254564A1 (en) | 2007-12-12 | 2010-12-01 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US7888662B2 (en) | 2008-06-20 | 2011-02-15 | Varian Semiconductor Equipment Associates, Inc. | Ion source cleaning method and apparatus |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
WO2012154194A1 (en) * | 2011-05-09 | 2012-11-15 | Forma Tm, Llc | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt) |
US9663498B2 (en) | 2013-12-20 | 2017-05-30 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
RU2017145976A (ru) | 2015-06-12 | 2019-07-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна |
KR20180064373A (ko) | 2015-07-15 | 2018-06-14 | 엑소반트 사이언시즈 게엠베하 | 신경퇴행성 질환과 관련된 환각의 예방 및 치료에 유용한 5-ht2a 세로토닌 수용체의 조절자로서의 다이아릴 및 아릴헤테로아릴 우레아 유도체 |
WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB947606A (en) * | 1961-04-10 | 1964-01-22 | Ici Ltd | N-substituted piperazines |
US4808595A (en) * | 1986-12-24 | 1989-02-28 | Merck & Co., Inc. | Furopyridine sulfonamides and their opthalmological compositions |
WO1994021619A1 (en) * | 1993-03-16 | 1994-09-29 | Pfizer Inc. | Naphthalene derivatives |
EP0701819A2 (en) * | 1994-09-14 | 1996-03-20 | Pfizer Inc. | Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
WO1998027081A1 (en) * | 1996-12-19 | 1998-06-25 | Smithkline Beecham Plc | Sulphonamide derivatives, process for their preparation, and their use as medicaments |
WO2000012073A1 (en) * | 1998-08-28 | 2000-03-09 | Smithkline Beecham P.L.C. | Use of 5ht-6 antagonists |
WO2000055159A2 (en) * | 1999-03-04 | 2000-09-21 | Glaxo Group Limited | Substituted aza-oxindole derivatives |
WO2001032660A1 (en) * | 1999-11-05 | 2001-05-10 | Nps Allelix Corp. | Compounds having 5-ht6 receptor antagonist activity |
WO2001032646A2 (en) * | 1999-11-05 | 2001-05-10 | Smithkline Beecham P.L.C. | Sulfonamide derivatives |
WO2001085722A1 (en) * | 2000-05-05 | 2001-11-15 | Cor Therapeutics, Inc. | Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors |
WO2001096336A2 (en) * | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 6,5-fused bicyclic heterocycles |
WO2002032863A1 (en) * | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
WO2002092585A1 (en) * | 2001-05-11 | 2002-11-21 | Biovitrum Ab | Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
WO2002098857A1 (en) * | 2001-06-07 | 2002-12-12 | F. Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
WO2002100822A1 (en) * | 2001-06-11 | 2002-12-19 | Biovitrum Ab | Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes |
-
2003
- 2003-06-19 CA CA002486989A patent/CA2486989A1/en not_active Abandoned
- 2003-06-19 WO PCT/SE2003/001061 patent/WO2004000828A1/en active Application Filing
- 2003-06-19 EA EA200600975A patent/EA011581B1/ru not_active IP Right Cessation
- 2003-06-19 NZ NZ536600A patent/NZ536600A/en unknown
- 2003-06-19 MX MXPA04012914A patent/MXPA04012914A/es not_active Application Discontinuation
- 2003-06-19 RS YU111204A patent/RS111204A/sr unknown
- 2003-06-19 NZ NZ552282A patent/NZ552282A/en unknown
- 2003-06-19 BR BR0311952-1A patent/BR0311952A/pt not_active IP Right Cessation
- 2003-06-19 NZ NZ552283A patent/NZ552283A/en unknown
- 2003-06-19 CN CN038144328A patent/CN1662521A/zh active Pending
- 2003-06-19 EA EA200500054A patent/EA008835B1/ru not_active IP Right Cessation
- 2003-06-19 EP EP03760999A patent/EP1513828A1/en not_active Ceased
- 2003-06-19 AU AU2003243091A patent/AU2003243091A1/en not_active Abandoned
- 2003-06-19 SG SG200604188-3A patent/SG156524A1/en unknown
-
2004
- 2004-11-04 IL IL16505104A patent/IL165051A0/xx unknown
-
2005
- 2005-01-19 NO NO20050294A patent/NO20050294L/no not_active Application Discontinuation
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB947606A (en) * | 1961-04-10 | 1964-01-22 | Ici Ltd | N-substituted piperazines |
US4808595A (en) * | 1986-12-24 | 1989-02-28 | Merck & Co., Inc. | Furopyridine sulfonamides and their opthalmological compositions |
WO1994021619A1 (en) * | 1993-03-16 | 1994-09-29 | Pfizer Inc. | Naphthalene derivatives |
EP0701819A2 (en) * | 1994-09-14 | 1996-03-20 | Pfizer Inc. | Novel compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
WO1998027081A1 (en) * | 1996-12-19 | 1998-06-25 | Smithkline Beecham Plc | Sulphonamide derivatives, process for their preparation, and their use as medicaments |
WO2000012073A1 (en) * | 1998-08-28 | 2000-03-09 | Smithkline Beecham P.L.C. | Use of 5ht-6 antagonists |
WO2000055159A2 (en) * | 1999-03-04 | 2000-09-21 | Glaxo Group Limited | Substituted aza-oxindole derivatives |
WO2001032660A1 (en) * | 1999-11-05 | 2001-05-10 | Nps Allelix Corp. | Compounds having 5-ht6 receptor antagonist activity |
WO2001032646A2 (en) * | 1999-11-05 | 2001-05-10 | Smithkline Beecham P.L.C. | Sulfonamide derivatives |
WO2001085722A1 (en) * | 2000-05-05 | 2001-11-15 | Cor Therapeutics, Inc. | Heterobicyclic sulfonamides and their use as platelet adp receptor inhibitors |
WO2001096336A2 (en) * | 2000-06-14 | 2001-12-20 | Warner-Lambert Company | 6,5-fused bicyclic heterocycles |
WO2002032863A1 (en) * | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
WO2002092585A1 (en) * | 2001-05-11 | 2002-11-21 | Biovitrum Ab | Novel, arylsusfonamide compounds for the treatment of obesity, type ii diabetes and cns-disorders |
WO2002098857A1 (en) * | 2001-06-07 | 2002-12-12 | F. Hoffmann-La Roche Ag | New indole derivatives with 5-ht6 receptor affinity |
WO2002100822A1 (en) * | 2001-06-11 | 2002-12-19 | Biovitrum Ab | Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes |
Non-Patent Citations (1)
Title |
---|
Bioorganic & Medicinal Chemistry Letters, vol. 10, No. 15, 2000, Methvin Isaac et al.: "6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-Bicyclopiperidinyl-1-arylsulfonylindoles Derivatives as Novel, Potent, and Selective 5-HT6 Receptor Antagonists", page 1719 - page 1721, compound 3 * |
Also Published As
Publication number | Publication date |
---|---|
AU2003243091A1 (en) | 2004-01-06 |
BR0311952A (pt) | 2005-04-19 |
EA200500054A1 (ru) | 2005-06-30 |
EA200600975A1 (ru) | 2006-10-27 |
CA2486989A1 (en) | 2003-12-31 |
NZ536600A (en) | 2007-08-31 |
WO2004000828A1 (en) | 2003-12-31 |
NZ552283A (en) | 2008-07-31 |
IL165051A0 (en) | 2005-12-18 |
MXPA04012914A (es) | 2005-03-31 |
NZ552282A (en) | 2008-07-31 |
EA011581B1 (ru) | 2009-04-28 |
CN1662521A (zh) | 2005-08-31 |
RS111204A (en) | 2006-12-15 |
SG156524A1 (en) | 2009-11-26 |
NO20050294L (no) | 2005-02-04 |
EP1513828A1 (en) | 2005-03-16 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |