GB947606A - N-substituted piperazines - Google Patents

N-substituted piperazines

Info

Publication number
GB947606A
GB947606A GB1280661A GB1280661A GB947606A GB 947606 A GB947606 A GB 947606A GB 1280661 A GB1280661 A GB 1280661A GB 1280661 A GB1280661 A GB 1280661A GB 947606 A GB947606 A GB 947606A
Authority
GB
United Kingdom
Prior art keywords
sulphonic acid
compounds
acid group
acid groups
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1280661A
Inventor
Cyril Morris
William Byres Mckay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB1280661A priority Critical patent/GB947606A/en
Publication of GB947606A publication Critical patent/GB947606A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Abstract

The invention comprises compounds of the general formula: <FORM:0947606/C2/1> in which X is hydrogen, a halogen or a sulphonic acid group; one Y is a hydrogen atom or a sulphonic acid group, and the other Y is a hydrogen atom, a hydroxy or sulphonic acid group and the naphthalene nucleus may carry additional sulphonic acid groups, provided that the compounds contain 1 or 2 sulphonic acid groups. The compounds are made by heating piperazine with a naphthalene compound of the formula: <FORM:0947606/C2/2> in which Z is -OH or -NH2 possibly with additional sulphonic acid groups, as above. The process may be carried out by heating in water at a temperature between 90 DEG and 150 DEG C. and preferably in the presence of an alkali metal sulphite or bisulphite. Numerous examples of compounds prepared are given. The compounds are used as intermediate for making dye stuffs.
GB1280661A 1961-04-10 1961-04-10 N-substituted piperazines Expired GB947606A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1280661A GB947606A (en) 1961-04-10 1961-04-10 N-substituted piperazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1280661A GB947606A (en) 1961-04-10 1961-04-10 N-substituted piperazines

Publications (1)

Publication Number Publication Date
GB947606A true GB947606A (en) 1964-01-22

Family

ID=10011491

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1280661A Expired GB947606A (en) 1961-04-10 1961-04-10 N-substituted piperazines

Country Status (1)

Country Link
GB (1) GB947606A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556889A1 (en) * 1992-02-18 1993-08-25 Duphar International Research B.V Method of preparing aryl(homo)piperazines
WO2004000828A1 (en) * 2002-06-20 2003-12-31 Biovitrum Ab New compounds useful for the treatment of obesity, type ii diabetes and cns disorders
US7144883B2 (en) 2001-06-11 2006-12-05 Biovitrum Ab Bicyclic sulfonamide compounds
US7943639B2 (en) 2002-06-20 2011-05-17 Proximagen Limited Compounds

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0556889A1 (en) * 1992-02-18 1993-08-25 Duphar International Research B.V Method of preparing aryl(homo)piperazines
US5463050A (en) * 1992-02-18 1995-10-31 Duphar International Research, B.V. Method of preparing aryl(homo)piperazines
US7144883B2 (en) 2001-06-11 2006-12-05 Biovitrum Ab Bicyclic sulfonamide compounds
US7572787B2 (en) 2001-06-11 2009-08-11 Biovitrum Ab Substituted naphthalene sulfonamides
WO2004000828A1 (en) * 2002-06-20 2003-12-31 Biovitrum Ab New compounds useful for the treatment of obesity, type ii diabetes and cns disorders
EA008835B1 (en) * 2002-06-20 2007-08-31 Биовитрум Аб Substituted sulfone and sulfonamides and pharmaceutical compositions based thereon useful for the treatment of obesity, type ii diabetes cns disorders
EA011581B1 (en) * 2002-06-20 2009-04-28 Биовитрум Аб (Пабл) Heterocyclic compounds useful for the treatment of obesity and cns disorders
US7943639B2 (en) 2002-06-20 2011-05-17 Proximagen Limited Compounds

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