EA008195B1 - Применение тория-227 в лучевой терапии заболеваний мягких тканей - Google Patents
Применение тория-227 в лучевой терапии заболеваний мягких тканей Download PDFInfo
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- EA008195B1 EA008195B1 EA200501456A EA200501456A EA008195B1 EA 008195 B1 EA008195 B1 EA 008195B1 EA 200501456 A EA200501456 A EA 200501456A EA 200501456 A EA200501456 A EA 200501456A EA 008195 B1 EA008195 B1 EA 008195B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- thorium
- targeted delivery
- kbq
- complex
- complexing agent
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
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- Optics & Photonics (AREA)
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- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Radiation-Therapy Devices (AREA)
- Medicinal Preparation (AREA)
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| PCT/GB2004/001654 WO2004091668A1 (en) | 2003-04-15 | 2004-04-15 | Thorium-227 for use in radiotherapy of soft tissue disease |
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| EA200501456A1 EA200501456A1 (ru) | 2006-06-30 |
| EA008195B1 true EA008195B1 (ru) | 2007-04-27 |
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| EA200501456A EA008195B1 (ru) | 2003-04-15 | 2004-04-15 | Применение тория-227 в лучевой терапии заболеваний мягких тканей |
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| PL (1) | PL1617876T3 (enExample) |
| PT (1) | PT1617876E (enExample) |
| ZA (1) | ZA200507983B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2767567C1 (ru) * | 2020-10-27 | 2022-03-17 | Станислав Анатольевич Дороватовский | Комплексные соединения, содержащие в своем составе радионуклид 227Th, а также бисфосфонатный фрагмент, способы их получения, а также потенциальное применение в качестве действующего вещества в составе остеотропного радиофармацевтического лекарственного препарата |
| RU2768732C2 (ru) * | 2016-01-05 | 2022-03-24 | Байер Ас | Способ получения изотопа |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ543044A (en) * | 2003-04-15 | 2010-04-30 | Algeta As | Thorium-227 for use in radiotherapy of soft tissue disease |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201007354D0 (en) * | 2010-04-30 | 2010-06-16 | Algeta Asa | Method |
| GB201105298D0 (en) * | 2011-03-29 | 2011-05-11 | Algeta Asa | Pharmaceutical preparation |
| GB201600153D0 (en) * | 2016-01-05 | 2016-02-17 | Bayer As | Isotope preparation method |
| WO2018109667A1 (en) | 2016-12-15 | 2018-06-21 | Nestec Sa | Compositions and methods that modulate white blood cells or neutrophils in a companion animal |
| FR3088769B1 (fr) * | 2018-11-15 | 2020-12-25 | Orano Med | Procede de preparation d'au moins un generateur a haute teneur en radium-228 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010008625A1 (en) * | 1999-12-06 | 2001-07-19 | Larsen Roy H. | Receptor binding conjugates |
| WO2001060417A2 (en) * | 2000-02-21 | 2001-08-23 | Anticancer Therapeutic Inventions As | Radioactive therapeutic liposomes |
| WO2001066155A2 (en) * | 2000-02-25 | 2001-09-13 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
| WO2002005859A2 (en) * | 2000-07-04 | 2002-01-24 | Anticancer Therapeutic Inventions As | Radiotherapy |
| WO2004043487A1 (en) * | 2002-11-14 | 2004-05-27 | Bracco Imaging S.P.A. | Agents for the diagnosis and treatment of tumours that expose altered proteins on the cell surface |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69007430T2 (de) * | 1989-06-19 | 1994-07-07 | Akzo Nobel N.V., Arnheim/Arnhem | Radioimmuntherapie unter alphapartikelausstrahlung. |
| SG52470A1 (en) * | 1992-04-13 | 1998-09-28 | Dow Chemical Co | Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof |
| CN1073860C (zh) * | 1998-08-20 | 2001-10-31 | 中国核动力研究设计院 | 用于骨肿瘤治疗或诊断的放射性药物药盒的制备方法 |
| MY133346A (en) * | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| NZ543044A (en) * | 2003-04-15 | 2010-04-30 | Algeta As | Thorium-227 for use in radiotherapy of soft tissue disease |
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2004
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- 2004-04-15 CA CA2522148A patent/CA2522148C/en not_active Expired - Lifetime
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- 2004-04-15 KR KR1020117003862A patent/KR101274867B1/ko not_active Expired - Lifetime
- 2004-04-15 ES ES04727587.0T patent/ES2486845T3/es not_active Expired - Lifetime
- 2004-04-15 JP JP2006506137A patent/JP5006032B2/ja not_active Expired - Lifetime
- 2004-04-15 PL PL04727587T patent/PL1617876T3/pl unknown
- 2004-04-15 CN CN200480016329A patent/CN100586484C/zh not_active Expired - Lifetime
- 2004-04-15 ZA ZA200507983A patent/ZA200507983B/en unknown
- 2004-04-15 KR KR1020057019497A patent/KR20060015507A/ko not_active Ceased
- 2004-04-15 NZ NZ595758A patent/NZ595758A/xx not_active IP Right Cessation
- 2004-04-15 DK DK04727587.0T patent/DK1617876T3/da active
- 2004-04-15 EA EA200501456A patent/EA008195B1/ru not_active IP Right Cessation
- 2004-04-15 BR BRPI0409387A patent/BRPI0409387B8/pt not_active IP Right Cessation
- 2004-04-15 EP EP04727587.0A patent/EP1617876B1/en not_active Expired - Lifetime
- 2004-04-15 MX MXPA05010804A patent/MXPA05010804A/es active IP Right Grant
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2005
- 2005-09-28 IL IL171148A patent/IL171148A/en active IP Right Grant
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010008625A1 (en) * | 1999-12-06 | 2001-07-19 | Larsen Roy H. | Receptor binding conjugates |
| WO2001060417A2 (en) * | 2000-02-21 | 2001-08-23 | Anticancer Therapeutic Inventions As | Radioactive therapeutic liposomes |
| WO2001066155A2 (en) * | 2000-02-25 | 2001-09-13 | Dangshe Ma | Actinium-225 complexes and conjugates for radioimmunotherapy |
| WO2002005859A2 (en) * | 2000-07-04 | 2002-01-24 | Anticancer Therapeutic Inventions As | Radiotherapy |
| WO2004043487A1 (en) * | 2002-11-14 | 2004-05-27 | Bracco Imaging S.P.A. | Agents for the diagnosis and treatment of tumours that expose altered proteins on the cell surface |
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| MILENIC D.E. ET AL.: "In vivo comparison of macrocyclic and acyclic ligands for radiolabeling of monoclonal antibodies with <177>Lu for radioimmunotherapeutic applications" NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 29, no, 4, May 2002 (2002-05), pages 431-442, XP004357346 ISSN: 0969-8051 the whole document * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2768732C2 (ru) * | 2016-01-05 | 2022-03-24 | Байер Ас | Способ получения изотопа |
| RU2767567C1 (ru) * | 2020-10-27 | 2022-03-17 | Станислав Анатольевич Дороватовский | Комплексные соединения, содержащие в своем составе радионуклид 227Th, а также бисфосфонатный фрагмент, способы их получения, а также потенциальное применение в качестве действующего вещества в составе остеотропного радиофармацевтического лекарственного препарата |
| WO2022093079A1 (ru) * | 2020-10-27 | 2022-05-05 | Станислав Анатольевич ДОРОВАТОВСКИЙ | Комплексное соединение y, содержащее радионуклид 227th и бисфосфонат и его применение |
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