CN100586484C - 用于放射治疗软组织疾病的钍-227 - Google Patents

用于放射治疗软组织疾病的钍-227 Download PDF

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Publication number
CN100586484C
CN100586484C CN200480016329A CN200480016329A CN100586484C CN 100586484 C CN100586484 C CN 100586484C CN 200480016329 A CN200480016329 A CN 200480016329A CN 200480016329 A CN200480016329 A CN 200480016329A CN 100586484 C CN100586484 C CN 100586484C
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CN
China
Prior art keywords
thorium
soft tissue
kbq
complex
radium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN200480016329A
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English (en)
Chinese (zh)
Other versions
CN1805760A (zh
Inventor
罗伊·拉森
奥伊文德·布鲁兰德
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Bayer AS
Original Assignee
Algeta ASA
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Filing date
Publication date
Priority claimed from GBGB0308731.9A external-priority patent/GB0308731D0/en
Application filed by Algeta ASA filed Critical Algeta ASA
Publication of CN1805760A publication Critical patent/CN1805760A/zh
Application granted granted Critical
Publication of CN100586484C publication Critical patent/CN100586484C/zh
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicinal Preparation (AREA)
CN200480016329A 2003-04-15 2004-04-15 用于放射治疗软组织疾病的钍-227 Expired - Lifetime CN100586484C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308731.9 2003-04-15
GBGB0308731.9A GB0308731D0 (en) 2003-04-15 2003-04-15 Method of radiotherapy

Publications (2)

Publication Number Publication Date
CN1805760A CN1805760A (zh) 2006-07-19
CN100586484C true CN100586484C (zh) 2010-02-03

Family

ID=35385222

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200480016329A Expired - Lifetime CN100586484C (zh) 2003-04-15 2004-04-15 用于放射治疗软组织疾病的钍-227

Country Status (18)

Country Link
EP (1) EP1617876B1 (enExample)
JP (2) JP5006032B2 (enExample)
KR (2) KR101274867B1 (enExample)
CN (1) CN100586484C (enExample)
AU (1) AU2004229218B2 (enExample)
BR (1) BRPI0409387B8 (enExample)
CA (1) CA2522148C (enExample)
CY (1) CY1115407T1 (enExample)
DK (1) DK1617876T3 (enExample)
EA (1) EA008195B1 (enExample)
ES (1) ES2486845T3 (enExample)
IL (1) IL171148A (enExample)
MX (1) MXPA05010804A (enExample)
NO (1) NO332931B1 (enExample)
NZ (3) NZ543044A (enExample)
PL (1) PL1617876T3 (enExample)
PT (1) PT1617876E (enExample)
ZA (1) ZA200507983B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103648534A (zh) * 2011-03-29 2014-03-19 艾尔格塔公司 药物制剂

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ543044A (en) * 2003-04-15 2010-04-30 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease
GB201002508D0 (en) * 2010-02-12 2010-03-31 Algeta As Product
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
GB201600154D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
WO2018109667A1 (en) 2016-12-15 2018-06-21 Nestec Sa Compositions and methods that modulate white blood cells or neutrophils in a companion animal
FR3088769B1 (fr) * 2018-11-15 2020-12-25 Orano Med Procede de preparation d'au moins un generateur a haute teneur en radium-228
RU2767567C1 (ru) * 2020-10-27 2022-03-17 Станислав Анатольевич Дороватовский Комплексные соединения, содержащие в своем составе радионуклид 227Th, а также бисфосфонатный фрагмент, способы их получения, а также потенциальное применение в качестве действующего вещества в составе остеотропного радиофармацевтического лекарственного препарата

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1210741A (zh) * 1998-08-20 1999-03-17 中国核动力研究设计院 用于骨肿瘤治疗或诊断的放射性药物药盒的制备方法
US20010008625A1 (en) * 1999-12-06 2001-07-19 Larsen Roy H. Receptor binding conjugates
WO2001066155A2 (en) * 2000-02-25 2001-09-13 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy
WO2002005859A2 (en) * 2000-07-04 2002-01-24 Anticancer Therapeutic Inventions As Radiotherapy
CN1404402A (zh) * 2000-02-21 2003-03-19 抗癌治疗发明公司 有放射活性的治疗性脂质体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69007430T2 (de) * 1989-06-19 1994-07-07 Akzo Nobel N.V., Arnheim/Arnhem Radioimmuntherapie unter alphapartikelausstrahlung.
SG52470A1 (en) * 1992-04-13 1998-09-28 Dow Chemical Co Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
ITMI20022411A1 (it) * 2002-11-14 2004-05-15 Bracco Imaging Spa Agenti per la diagnosi e la terapia di tumori che espongono sulla superficie delle cellule proteine alterate.
NZ543044A (en) * 2003-04-15 2010-04-30 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1210741A (zh) * 1998-08-20 1999-03-17 中国核动力研究设计院 用于骨肿瘤治疗或诊断的放射性药物药盒的制备方法
US20010008625A1 (en) * 1999-12-06 2001-07-19 Larsen Roy H. Receptor binding conjugates
CN1404402A (zh) * 2000-02-21 2003-03-19 抗癌治疗发明公司 有放射活性的治疗性脂质体
WO2001066155A2 (en) * 2000-02-25 2001-09-13 Dangshe Ma Actinium-225 complexes and conjugates for radioimmunotherapy
WO2002005859A2 (en) * 2000-07-04 2002-01-24 Anticancer Therapeutic Inventions As Radiotherapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103648534A (zh) * 2011-03-29 2014-03-19 艾尔格塔公司 药物制剂

Also Published As

Publication number Publication date
NO20055390D0 (no) 2005-11-15
JP5006032B2 (ja) 2012-08-22
IL171148A (en) 2013-12-31
NZ595758A (en) 2013-02-22
NZ543044A (en) 2010-04-30
ES2486845T3 (es) 2014-08-19
EP1617876B1 (en) 2014-05-14
BRPI0409387A (pt) 2006-04-18
KR20060015507A (ko) 2006-02-17
AU2004229218B2 (en) 2009-05-07
CA2522148A1 (en) 2004-10-28
BRPI0409387B1 (pt) 2021-05-11
HK1094150A1 (zh) 2007-03-23
PL1617876T3 (pl) 2015-03-31
KR20110022743A (ko) 2011-03-07
PT1617876E (pt) 2014-08-04
CY1115407T1 (el) 2017-01-04
MXPA05010804A (es) 2006-03-09
ZA200507983B (en) 2007-03-28
NO332931B1 (no) 2013-02-04
JP2006523664A (ja) 2006-10-19
DK1617876T3 (da) 2014-07-21
NZ606996A (en) 2014-08-29
AU2004229218A1 (en) 2004-10-28
JP2012051942A (ja) 2012-03-15
EA008195B1 (ru) 2007-04-27
CA2522148C (en) 2010-07-13
KR101274867B1 (ko) 2013-06-13
EA200501456A1 (ru) 2006-06-30
EP1617876A1 (en) 2006-01-25
BRPI0409387B8 (pt) 2021-05-25
JP5468597B2 (ja) 2014-04-09
CN1805760A (zh) 2006-07-19
NO20055390L (no) 2006-01-16

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