EA007844B1 - Применение ферментированного экстракта проростков пшеницы в качестве противовоспалительного агента - Google Patents
Применение ферментированного экстракта проростков пшеницы в качестве противовоспалительного агента Download PDFInfo
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- EA007844B1 EA007844B1 EA200500326A EA200500326A EA007844B1 EA 007844 B1 EA007844 B1 EA 007844B1 EA 200500326 A EA200500326 A EA 200500326A EA 200500326 A EA200500326 A EA 200500326A EA 007844 B1 EA007844 B1 EA 007844B1
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- Eurasian Patent Office
- Prior art keywords
- inflammatory agent
- day
- treatment
- arthritis
- inflammatory
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003448 neutrophilic effect Effects 0.000 description 1
- 239000012457 nonaqueous media Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 208000030428 polyarticular arthritis Diseases 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010517 secondary reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000015424 sodium Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000007473 univariate analysis Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0202638A HUP0202638A3 (en) | 2002-08-09 | 2002-08-09 | Use of fermented wheat-germ extract for preparation of antiphlogistic compositions |
| PCT/HU2003/000065 WO2004014406A1 (en) | 2002-08-09 | 2003-08-08 | Use of fermented wheat germ extract as anti-inflammatory agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200500326A1 EA200500326A1 (ru) | 2005-06-30 |
| EA007844B1 true EA007844B1 (ru) | 2007-02-27 |
Family
ID=89980690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200500326A EA007844B1 (ru) | 2002-08-09 | 2003-08-08 | Применение ферментированного экстракта проростков пшеницы в качестве противовоспалительного агента |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1536809A1 (ja) |
| JP (1) | JP2006501214A (ja) |
| KR (1) | KR20050059066A (ja) |
| CN (1) | CN1674924A (ja) |
| AU (1) | AU2003255854A1 (ja) |
| BR (1) | BR0313589A (ja) |
| CA (1) | CA2494744A1 (ja) |
| EA (1) | EA007844B1 (ja) |
| HR (1) | HRP20050114A2 (ja) |
| HU (1) | HUP0202638A3 (ja) |
| IL (1) | IL166732A0 (ja) |
| MX (1) | MXPA05001469A (ja) |
| NO (1) | NO20051168L (ja) |
| PL (1) | PL375391A1 (ja) |
| WO (1) | WO2004014406A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2908998A1 (fr) * | 2006-11-24 | 2008-05-30 | Bao Quoc Ho | Nouveau produit enzymatique et son utilisation. |
| HUP0900614A2 (en) | 2009-09-29 | 2011-05-30 | Mate Dr Hidvegi | Preparation comprising dehydrated, fermented material with amorphous crystaline structure and process for its production |
| WO2010135580A2 (en) * | 2009-05-20 | 2010-11-25 | The Regents Of The University Of California | Fermented wheat germ proteins (fwgp) for the treatment of cancer |
| US20120164132A1 (en) * | 2010-08-02 | 2012-06-28 | Mate Hidvegi | Anticancer and immunomodulating molecules and fractions containing said molecules, and process for preparing said fractions and said molecules from fermented vegetal material, and their uses |
| GB201108560D0 (en) | 2011-05-20 | 2011-07-06 | 3 Ch Ltd | Use of fermented wheat germ in the treatment of inflammatory bowel disease |
| GB201110746D0 (en) | 2011-06-23 | 2011-08-10 | Biropharma Uk Ltd | Wheat germ derived material |
| JP6115995B2 (ja) * | 2013-04-24 | 2017-04-19 | 株式会社日清製粉グループ本社 | 非酵素的糖化反応抑制剤 |
| CN104381450A (zh) * | 2014-10-15 | 2015-03-04 | 张士远 | 治疗胃粘膜损伤的保健牛奶及其制备方法 |
| WO2017196048A1 (ko) * | 2016-05-11 | 2017-11-16 | 씨제이제일제당 (주) | 밀배아 발효물의 추출물을 유효성분으로 함유하는 피부 주름 개선 외용제 조성물 |
| WO2018056600A1 (ko) * | 2016-09-23 | 2018-03-29 | 씨제이제일제당 (주) | 밀배아 발효물의 추출물을 유효성분으로 함유하는 피부진정 외용제 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07242537A (ja) * | 1994-03-04 | 1995-09-19 | Kibun Foods Inc | 抗炎症活性物質の製造方法および抗炎症剤 |
| JPH08337536A (ja) * | 1995-06-14 | 1996-12-24 | Asahi Breweries Ltd | 抗活性酸素作用剤並びにこれを有効成分とする抗活性酸素剤、化粧料、食品及び医薬品 |
| WO1999008694A1 (en) * | 1997-08-13 | 1999-02-25 | Hidvegi Mate | Immunostimulatory and metastasis inhibiting fermented vegetal material |
-
2002
- 2002-08-09 HU HU0202638A patent/HUP0202638A3/hu unknown
-
2003
- 2003-08-08 CN CNA038189003A patent/CN1674924A/zh active Pending
- 2003-08-08 AU AU2003255854A patent/AU2003255854A1/en not_active Abandoned
- 2003-08-08 KR KR1020057002283A patent/KR20050059066A/ko not_active Application Discontinuation
- 2003-08-08 BR BR0313589-6A patent/BR0313589A/pt not_active Application Discontinuation
- 2003-08-08 CA CA002494744A patent/CA2494744A1/en not_active Abandoned
- 2003-08-08 EA EA200500326A patent/EA007844B1/ru not_active IP Right Cessation
- 2003-08-08 EP EP03784303A patent/EP1536809A1/en not_active Withdrawn
- 2003-08-08 JP JP2004527076A patent/JP2006501214A/ja active Pending
- 2003-08-08 PL PL03375391A patent/PL375391A1/xx not_active Application Discontinuation
- 2003-08-08 WO PCT/HU2003/000065 patent/WO2004014406A1/en not_active Application Discontinuation
- 2003-08-08 MX MXPA05001469A patent/MXPA05001469A/es unknown
-
2005
- 2005-02-03 HR HR20050114A patent/HRP20050114A2/hr not_active Application Discontinuation
- 2005-02-07 IL IL16673205A patent/IL166732A0/xx unknown
- 2005-03-04 NO NO20051168A patent/NO20051168L/no not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07242537A (ja) * | 1994-03-04 | 1995-09-19 | Kibun Foods Inc | 抗炎症活性物質の製造方法および抗炎症剤 |
| JPH08337536A (ja) * | 1995-06-14 | 1996-12-24 | Asahi Breweries Ltd | 抗活性酸素作用剤並びにこれを有効成分とする抗活性酸素剤、化粧料、食品及び医薬品 |
| WO1999008694A1 (en) * | 1997-08-13 | 1999-02-25 | Hidvegi Mate | Immunostimulatory and metastasis inhibiting fermented vegetal material |
Non-Patent Citations (5)
| Title |
|---|
| DATABASE CA 'Online! CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KOBAYASHI, AKIO ET AL.: "Manufacture of anti-inflammatory substances and benzoquinones and hydroxybiphenyls as inflammation inhibitors", retrieved from STN Database accession no. 1995:967539 XP002260816 abstract see Chemical Registry No. 530-55-2 & JP 07 242537 A (KIBUN SHOKUHIN KK, JAPAN), 19 September 1995 (1995-09-19) * |
| DATABASE WPI Section Ch, Week 199710, Derwent Publications Ltd., London, GB; Class B04, AN 1997-103658 XP002260818 & JP 08 337536 A (ASAHI BREWERIES LTD), 24 December 1996 (1996-12-24) abstract * |
| HIDVEGI M. ET AL.: "Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals.," ANTICANCER RESEARCH. GREECE 1998 JUL-AUG, vol. 18, no. 4A, July 1998 (1998-07), pages 2353-2358, XP009020669 ISSN: 0250-7005 abstract * |
| HIDVEGI M. ET AL.: "MSC, a new benzoquinone-containing natural product with antimetastatic effect.," CANCER BIOTHERAPY & RADIOPHARMACEUTICALS. UNITED STATES AUG 1999, vol. 14, no. 4, August 1999 (1999-08), pages 277-289, XP009020668 ISSN: 1084-9785 abstract "Combined use of AVEMAR and cytostatics" on page 280 figures 4-6 * |
| OTSUKA H. ET AL.: "STUDIES ON ANTI-INFLAMMATORY AGENTS. III. AN ANTI-INFLAMMATORY CONSTITUENT OF THE GENUS ACER", YAKUGAKI ZASSHI , vol. 101, no. 12, 1981, pages 1108-1112, XP00902064, JAPAN abstract; table II * |
Also Published As
| Publication number | Publication date |
|---|---|
| NO20051168L (no) | 2005-03-04 |
| WO2004014406A1 (en) | 2004-02-19 |
| CA2494744A1 (en) | 2004-02-19 |
| HRP20050114A2 (en) | 2005-10-31 |
| KR20050059066A (ko) | 2005-06-17 |
| HUP0202638A3 (en) | 2007-08-28 |
| AU2003255854A1 (en) | 2004-02-25 |
| HU0202638D0 (ja) | 2002-10-28 |
| EA200500326A1 (ru) | 2005-06-30 |
| HUP0202638A2 (hu) | 2004-06-28 |
| CN1674924A (zh) | 2005-09-28 |
| IL166732A0 (en) | 2006-01-15 |
| EP1536809A1 (en) | 2005-06-08 |
| MXPA05001469A (es) | 2005-06-06 |
| PL375391A1 (en) | 2005-11-28 |
| BR0313589A (pt) | 2005-07-12 |
| JP2006501214A (ja) | 2006-01-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |