EA005525B1 - Замещенные бициклические производные для лечения аномального роста клеток - Google Patents

Замещенные бициклические производные для лечения аномального роста клеток Download PDF

Info

Publication number
EA005525B1
EA005525B1 EA200201277A EA200201277A EA005525B1 EA 005525 B1 EA005525 B1 EA 005525B1 EA 200201277 A EA200201277 A EA 200201277A EA 200201277 A EA200201277 A EA 200201277A EA 005525 B1 EA005525 B1 EA 005525B1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenylamino
yloxy
methyl
methylpyridin
quinazolin
Prior art date
Application number
EA200201277A
Other languages
English (en)
Russian (ru)
Other versions
EA200201277A1 (ru
Inventor
Джон Чарльз Кат
Самит Кумар Бхаттачариа
Джоэл Моррис
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200201277A1 publication Critical patent/EA200201277A1/ru
Publication of EA005525B1 publication Critical patent/EA005525B1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72Quinazolines; Hydrogenated quinazolines
    • C07D239/86Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
EA200201277A 2000-06-22 2001-06-14 Замещенные бициклические производные для лечения аномального роста клеток EA005525B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21313600P 2000-06-22 2000-06-22
PCT/IB2001/001046 WO2001098277A2 (en) 2000-06-22 2001-06-14 Substituted bicyclic derivatives for the treatment of abnormal cell growth

Publications (2)

Publication Number Publication Date
EA200201277A1 EA200201277A1 (ru) 2003-06-26
EA005525B1 true EA005525B1 (ru) 2005-04-28

Family

ID=22793862

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200201277A EA005525B1 (ru) 2000-06-22 2001-06-14 Замещенные бициклические производные для лечения аномального роста клеток

Country Status (42)

Country Link
US (2) US6890924B2 (enExample)
EP (1) EP1292591B1 (enExample)
JP (1) JP4044839B2 (enExample)
KR (1) KR100545537B1 (enExample)
CN (3) CN1330640C (enExample)
AP (1) AP2001002192A0 (enExample)
AR (1) AR032353A1 (enExample)
AT (1) ATE288431T1 (enExample)
AU (1) AU2001264159A1 (enExample)
BG (1) BG107269A (enExample)
BR (1) BR0111548A (enExample)
CA (1) CA2413424C (enExample)
CZ (1) CZ20023951A3 (enExample)
DE (1) DE60108754T2 (enExample)
DK (1) DK1292591T3 (enExample)
DZ (1) DZ3407A1 (enExample)
EA (1) EA005525B1 (enExample)
EC (1) ECSP024393A (enExample)
EE (1) EE200200710A (enExample)
ES (1) ES2236240T3 (enExample)
GE (1) GEP20063831B (enExample)
HR (1) HRP20021005A2 (enExample)
HU (1) HUP0301120A2 (enExample)
IL (1) IL152985A0 (enExample)
IS (1) IS6616A (enExample)
MA (1) MA26914A1 (enExample)
MX (1) MXPA02012870A (enExample)
MY (1) MY127181A (enExample)
NO (1) NO20026166D0 (enExample)
NZ (1) NZ522568A (enExample)
OA (1) OA12291A (enExample)
PA (1) PA8520301A1 (enExample)
PE (1) PE20020257A1 (enExample)
PL (1) PL359557A1 (enExample)
PT (1) PT1292591E (enExample)
SK (1) SK17102002A3 (enExample)
SV (1) SV2002000504A (enExample)
TN (1) TNSN01091A1 (enExample)
UA (1) UA73990C2 (enExample)
WO (1) WO2001098277A2 (enExample)
YU (1) YU95102A (enExample)
ZA (1) ZA200210231B (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772432B2 (en) * 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
RS49779B (sr) * 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
WO2000020402A1 (en) * 1998-10-01 2000-04-13 Astrazeneca Ab Chemical compounds
KR100545537B1 (ko) * 2000-06-22 2006-01-25 화이자 프로덕츠 인코포레이티드 비정상적 세포 성장 치료용의 치환된 이환식 유도체
KR100861486B1 (ko) * 2001-02-21 2008-10-02 미쓰비시 타나베 파마 코퍼레이션 퀴나졸린 유도체
US20030144308A1 (en) * 2001-09-24 2003-07-31 Bauer Paul H. Fructose 1,6-bisphosphatase inhibitors
KR20040054813A (ko) * 2001-11-30 2004-06-25 화이자 프로덕츠 인코포레이티드 비정상적 세포성장을 치료하기 위한 치환된 비사이클릭유도체의 제조방법
BR0214499A (pt) * 2001-12-12 2005-05-10 Pfizer Prod Inc Derivados de quinazolina para o tratamento do crescimento anormal das células
JP4202926B2 (ja) * 2001-12-12 2008-12-24 ファイザー・プロダクツ・インク E−2−メトキシ−n−(3−(4−(3−メチル−ピリジン−3−イロキシ)−フェニルアミノ)−キナゾリン−6−イル)−アリル)−アセトアミドの塩形態、その製造および癌に対するその使用
US6924285B2 (en) 2002-03-30 2005-08-02 Boehringer Ingelheim Pharma Gmbh & Co. Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them
EP1521747B1 (en) 2002-07-15 2018-09-05 Symphony Evolution, Inc. Receptor-type kinase modulators and methods of use
JP4611745B2 (ja) 2002-11-20 2011-01-12 アレイ バイオファーマ、インコーポレイテッド ErbB2及びEGFR阻害剤としてのシアノグアニジン及びシアノアミジン
US7488823B2 (en) * 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
CA2510323A1 (en) * 2002-12-18 2004-07-01 Pfizer Products Inc. 4-anilino quinazoline derivatives for the treatment of abnormal cell growth
KR20050085835A (ko) * 2002-12-19 2005-08-29 화이자 프로덕츠 인코포레이티드 E-2-메톡시-n-(3-{4-[3-메틸-4-(6-메틸-피리딘-3-일옥시)-페닐아미노]-퀴나졸린-6-일}-알릴)-아세트아마이드의 착물, 및 그의 제조방법 및 용도
RS20050652A (sr) * 2003-04-09 2007-11-15 Pfizer Products Inc., Postupak za izradu derivata n- (((piridiniloksi)-fenilamino) kvinazolinil)-alil)acetamida i izvedenih jedinjenja kao i međuproizvodi ovih postupaka i postupci za izradu ovih međuproizvoda
CA2527017A1 (en) * 2003-05-27 2004-12-09 Pfizer Products Inc. Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors
JP5129957B2 (ja) * 2003-07-03 2013-01-30 ミリアド ジェネティクス, インコーポレイテッド カスパーゼの活性化因子およびアポトーシスの誘発因子としての4−アリールアミノ−キナゾリン
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
WO2006074147A2 (en) 2005-01-03 2006-07-13 Myriad Genetics, Inc. Nitrogen containing bicyclic compounds and therapeutical use thereof
CN1822853A (zh) * 2003-07-15 2006-08-23 加拿大国家研究委员会 用于治疗特征在于过度增殖皮肤细胞的疾病的人类甲状旁腺激素环状类似物
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
US7452895B2 (en) * 2003-08-14 2008-11-18 Array Biopharma Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
AU2004264726A1 (en) * 2003-08-18 2005-02-24 Pfizer Products Inc. Dosing schedule for erbB2 anticancer agents
UA84167C2 (ru) 2003-09-16 2008-09-25 Астразенека Аб Производные хиназолина как ингибиторы тирозинкиназы, способ их получения (варианты), фармацевтическая композиция на их основе
GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
EP2210607B1 (en) 2003-09-26 2011-08-17 Exelixis Inc. N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer
MXPA06005024A (es) * 2003-11-06 2006-07-06 Pfizer Prod Inc Combinaciones de inhibidor de erbb2 selectivo/anticuerpos anti-erbb en el tratamiento del cancer.
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
EP1713781B1 (en) 2004-02-03 2008-11-05 AstraZeneca AB Quinazoline derivatives
US20050192298A1 (en) * 2004-02-27 2005-09-01 Pfizer Inc Crystal forms of E-2-Methoxy-N-(3-{4-[3-methyl-4-(6-methyl-pyridin-3-yloxy)-phenylamino]-quinazolin-6-yl}-allyl)-acetamide
CN101014365B (zh) 2004-07-16 2011-04-13 辉瑞产品公司 使用抗-igf-1r抗体联合治疗非血液的恶性肿瘤
KR20070058529A (ko) * 2004-09-01 2007-06-08 미쯔비시 웰 파마 가부시키가이샤 분자 샤프론 기능 조절제
WO2006071079A1 (en) * 2004-12-29 2006-07-06 Hanmi Pharm. Co., Ltd. Quinazoline derivatives for inhibiting cancer cell growth and method for the preparation thereof
KR100735639B1 (ko) 2004-12-29 2007-07-04 한미약품 주식회사 암세포 성장 억제 효과를 갖는 퀴나졸린 유도체 및 이의제조방법
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
AU2006238930B2 (en) 2005-04-26 2010-12-23 Pfizer Inc. P-cadherin antibodies
CA2610491A1 (en) * 2005-06-03 2006-12-07 Pfizer Products Inc. Bicyclic derivatives for the treatment of abnormal cell growth
CA2610661A1 (en) * 2005-06-03 2006-12-07 Pfizer Products Inc. Combinations of erbb2 inhibitors with other therapeutic agents in the treatment of cancer
NZ566774A (en) 2005-09-07 2011-11-25 Pfizer Human monoclonal antibodies to activin receptor-like kinase-1
DK2090575T3 (da) 2005-11-15 2011-05-23 Array Biopharma Inc Fremgangsmåder og mellemprodukter til fremstillingen af N4 phenylquinazolin-4-aminderivater
GB0526552D0 (en) * 2005-12-29 2006-02-08 Morvus Technology Ltd New use
KR20090007792A (ko) 2006-05-09 2009-01-20 화이자 프로덕츠 인크. 시클로알킬아미노산 유도체 및 이들의 제약 조성물
WO2008002039A1 (en) * 2006-06-28 2008-01-03 Hanmi Pharm. Co., Ltd. Quinazoline derivatives for inhibiting the growth of cancer cell
US7547781B2 (en) 2006-09-11 2009-06-16 Curis, Inc. Quinazoline based EGFR inhibitors containing a zinc binding moiety
CN101535279B (zh) * 2006-09-11 2015-05-20 柯瑞斯公司 含锌结合基的喹唑啉基egfr抑制剂
KR20090077914A (ko) * 2006-09-11 2009-07-16 쿠리스 인코퍼레이션 항증식제로서의 다작용성 소분자
EP1921070A1 (de) 2006-11-10 2008-05-14 Boehringer Ingelheim Pharma GmbH & Co. KG Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstelllung
CN101611041A (zh) 2006-12-12 2009-12-23 武田药品工业株式会社 稠合杂环化合物
JP5377332B2 (ja) 2007-02-06 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 二環式へテロ環、それらの化合物を含む薬剤、その使用及びその製法
EP2851091B1 (en) 2007-04-13 2017-12-27 Dana-Farber Cancer Institute, Inc. Methods for treating cancer resistant to ERBB therapeutics
UA101357C2 (ru) 2008-02-07 2013-03-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх Спирогетероциклы, лекарственное средство, которое содержит эти соединения, их применение
UY31704A (es) 2008-03-12 2009-11-10 Takeda Pharmaceutical Compuesto heterociclico fusionado
US8426430B2 (en) * 2008-06-30 2013-04-23 Hutchison Medipharma Enterprises Limited Quinazoline derivatives
US8648191B2 (en) 2008-08-08 2014-02-11 Boehringer Ingelheim International Gmbh Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them
AU2010204619B2 (en) 2009-01-16 2016-08-11 Exelixis, Inc. Malate salt of N-(4-{ [ 6, 7-bis (methyloxy)-quinolin-4-yl] oxy}phenyl)-N'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer
UA108618C2 (uk) 2009-08-07 2015-05-25 Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
CA2772194A1 (en) 2009-09-01 2011-03-10 Pfizer Inc. Benzimidazole derivatives
US9265739B2 (en) 2010-06-02 2016-02-23 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to HER2/neu receptor complex
US8993634B2 (en) 2010-06-02 2015-03-31 The Trustees Of The University Of Pennsylvania Methods and use of compounds that bind to Her2/neu receptor complex
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
ES2543151T3 (es) 2010-10-20 2015-08-17 Pfizer Inc Derivados de 2-piridina como moduladores del receptor Smoothened
EP2758402B9 (en) 2011-09-22 2016-09-14 Pfizer Inc Pyrrolopyrimidine and purine derivatives
CN102872018B (zh) * 2012-10-23 2015-07-15 广州市恒诺康医药科技有限公司 酪氨酸激酶不可逆抑制剂及其制备方法和用途
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
UA115388C2 (uk) 2013-11-21 2017-10-25 Пфайзер Інк. 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань
WO2015155624A1 (en) 2014-04-10 2015-10-15 Pfizer Inc. Dihydropyrrolopyrimidine derivatives
CN106232598B (zh) 2014-04-30 2020-03-13 辉瑞公司 环烷基-连接的二杂环衍生物
KR101589632B1 (ko) 2014-06-03 2016-02-01 한국과학기술연구원 항암활성을 가지는 6-벤질옥시퀴나졸린-7-일유레아 유도체
WO2016001789A1 (en) 2014-06-30 2016-01-07 Pfizer Inc. Pyrimidine derivatives as pi3k inhibitors for use in the treatment of cancer
ES2980216T3 (es) 2015-07-01 2024-09-30 California Inst Of Techn Sistemas de administración basados en polímeros de ácido múcico catiónicos
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives
CN107141293B (zh) * 2016-03-01 2022-09-23 上海医药集团股份有限公司 一种含氮杂环化合物、制备方法、中间体、组合物和应用
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US20190381188A1 (en) 2018-06-13 2019-12-19 California Institute Of Technology Nanoparticles For Crossing The Blood Brain Barrier And Methods Of Treatment Using The Same
HRP20241743T1 (hr) 2018-09-18 2025-02-28 F. Hoffmann - La Roche Ag Derivati kinazolina kao antitumorska sredstva
AU2023243776A1 (en) * 2022-03-28 2024-09-12 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Nitrogen-containing heterocyclic compound, preparation method therefor, and pharmaceutical application thereof
WO2025067396A1 (zh) * 2023-09-27 2025-04-03 江苏恒瑞医药股份有限公司 一种喹唑啉衍生物的可药用盐、其结晶形式及用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW321649B (enExample) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
US6225318B1 (en) 1996-10-17 2001-05-01 Pfizer Inc 4-aminoquinazolone derivatives
ZA986732B (en) * 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
BR9914326A (pt) 1998-10-08 2001-06-26 Astrazeneca Ab Uso de um composto, composto, processo para a preparação do mesmo, composição farmacêutica, e, método para produzir um efeito antiangiogênico e/ou de redução da permeabilidade vascular em animais de sangue quente em necessidade de um tal tratamento
JP3270834B2 (ja) * 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
KR100545537B1 (ko) * 2000-06-22 2006-01-25 화이자 프로덕츠 인코포레이티드 비정상적 세포 성장 치료용의 치환된 이환식 유도체

Also Published As

Publication number Publication date
TNSN01091A1 (fr) 2005-11-10
BG107269A (bg) 2003-06-30
NZ522568A (en) 2004-12-24
SK17102002A3 (sk) 2004-04-06
HRP20021005A2 (en) 2004-02-29
EA200201277A1 (ru) 2003-06-26
CN101348467A (zh) 2009-01-21
US6890924B2 (en) 2005-05-10
CN1576275A (zh) 2005-02-09
BR0111548A (pt) 2003-05-06
AP2001002192A0 (en) 2002-12-21
DE60108754D1 (de) 2005-03-10
PE20020257A1 (es) 2002-04-08
ZA200210231B (en) 2004-02-12
MY127181A (en) 2006-11-30
CZ20023951A3 (cs) 2004-01-14
PL359557A1 (en) 2004-08-23
OA12291A (en) 2004-03-18
EP1292591B1 (en) 2005-02-02
AU2001264159A1 (en) 2002-01-02
US20050159435A1 (en) 2005-07-21
KR100545537B1 (ko) 2006-01-25
WO2001098277A2 (en) 2001-12-27
MXPA02012870A (es) 2003-05-14
PA8520301A1 (es) 2003-06-30
SV2002000504A (es) 2002-10-24
CN1330640C (zh) 2007-08-08
PT1292591E (pt) 2005-06-30
US7332493B2 (en) 2008-02-19
ES2236240T3 (es) 2005-07-16
CA2413424A1 (en) 2001-12-27
NO20026166L (no) 2002-12-20
NO20026166D0 (no) 2002-12-20
US20020169165A1 (en) 2002-11-14
HUP0301120A2 (hu) 2003-08-28
IL152985A0 (en) 2003-06-24
EE200200710A (et) 2004-06-15
MA26914A1 (fr) 2004-12-20
UA73990C2 (en) 2005-10-17
HK1069576A1 (en) 2005-05-27
CN1437594A (zh) 2003-08-20
DE60108754T2 (de) 2005-06-23
YU95102A (sh) 2005-11-28
ATE288431T1 (de) 2005-02-15
AR032353A1 (es) 2003-11-05
WO2001098277A3 (en) 2002-06-13
DZ3407A1 (enExample) 2001-12-27
EP1292591A2 (en) 2003-03-19
JP2004501139A (ja) 2004-01-15
KR20030016303A (ko) 2003-02-26
CA2413424C (en) 2007-10-02
ECSP024393A (es) 2003-02-06
IS6616A (is) 2002-11-14
GEP20063831B (en) 2006-05-25
JP4044839B2 (ja) 2008-02-06
DK1292591T3 (da) 2005-05-30

Similar Documents

Publication Publication Date Title
EA005525B1 (ru) Замещенные бициклические производные для лечения аномального роста клеток
JP4181502B2 (ja) 異常な細胞増殖を治療するためのキナゾリン誘導体
JP3270834B2 (ja) 抗がん剤として有用なヘテロ芳香族二環式誘導体
EA008448B1 (ru) Новые производные бензимидазола, полезные в качестве антипролиферативных агентов
US20050101618A1 (en) Selective erbB2 inhibitor/anti-erbB antibody combinations in the treatment of cancer
WO2006129163A1 (en) Combinations of erbb2 inhibitors with other therapeutic agents in the treatment of cancer
US6927220B2 (en) Bicyclic-substituted 4-amino-pyridopyrimidine derivatives
UA81915C2 (en) Novel venzoimidazole derivatives useful as antiproliferative agents

Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU