EA004745B1 - Тетрагидробензазепиновые производные в качестве агонистов дофаминовых рецепторов d1 - Google Patents

Тетрагидробензазепиновые производные в качестве агонистов дофаминовых рецепторов d1 Download PDF

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Publication number
EA004745B1
EA004745B1 EA200100783A EA200100783A EA004745B1 EA 004745 B1 EA004745 B1 EA 004745B1 EA 200100783 A EA200100783 A EA 200100783A EA 200100783 A EA200100783 A EA 200100783A EA 004745 B1 EA004745 B1 EA 004745B1
Authority
EA
Eurasian Patent Office
Prior art keywords
mmol
chloro
hydrogen
compound according
tetrahydro
Prior art date
Application number
EA200100783A
Other languages
English (en)
Russian (ru)
Other versions
EA200100783A1 (ru
Inventor
Гари Тилбрук
Original Assignee
Шайр Фармасьютикал Дивелопмент Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Шайр Фармасьютикал Дивелопмент Лимитед filed Critical Шайр Фармасьютикал Дивелопмент Лимитед
Publication of EA200100783A1 publication Critical patent/EA200100783A1/ru
Publication of EA004745B1 publication Critical patent/EA004745B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
EA200100783A 1999-02-17 2000-02-17 Тетрагидробензазепиновые производные в качестве агонистов дофаминовых рецепторов d1 EA004745B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9903671.7A GB9903671D0 (en) 1999-02-17 1999-02-17 Dopamine D-1 receptor agonist compounds
PCT/GB2000/000570 WO2000049000A1 (en) 1999-02-17 2000-02-17 Dopamine d1 receptor agonist compounds

Publications (2)

Publication Number Publication Date
EA200100783A1 EA200100783A1 (ru) 2002-02-28
EA004745B1 true EA004745B1 (ru) 2004-08-26

Family

ID=10847990

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100783A EA004745B1 (ru) 1999-02-17 2000-02-17 Тетрагидробензазепиновые производные в качестве агонистов дофаминовых рецепторов d1

Country Status (17)

Country Link
EP (1) EP1157009A1 (zh)
JP (1) JP2002537288A (zh)
KR (1) KR20010108228A (zh)
CN (1) CN1142916C (zh)
AU (1) AU767332B2 (zh)
BR (1) BR0008329A (zh)
CA (1) CA2363695A1 (zh)
CZ (1) CZ20012973A3 (zh)
EA (1) EA004745B1 (zh)
GB (1) GB9903671D0 (zh)
HU (1) HUP0200057A3 (zh)
IL (1) IL144810A0 (zh)
MX (1) MXPA01008294A (zh)
NO (1) NO20013978L (zh)
PL (1) PL349838A1 (zh)
WO (1) WO2000049000A1 (zh)
ZA (1) ZA200106478B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
JP5258561B2 (ja) 2005-07-15 2013-08-07 アルバニー モレキュラー リサーチ， インコーポレイテッド アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
EP1917275A4 (en) * 2005-08-03 2009-01-28 Mineuet Therapeutics Ltd MODULATION OF THE VOLTAGE-RELATED KV1.1 CALIUM CHANNEL OF T-CELLS FOR REGULATING SYNTHESIS AND DEGRADATION OF THE TUMOR NECROSIS FACTOR (TNF) AND FOR TREATING HUMAN DISEASES CAUSED BY HARMFULLY HIGH OR LOW TNF MIRRORS
CN101684096A (zh) * 2008-09-23 2010-03-31 中国科学院上海药物研究所 一类新型苯并氮杂卓类化合物及其制备方法和用途
CN102276531A (zh) * 2011-05-30 2011-12-14 扬子江药业集团广州海瑞药业有限公司 一种甲磺酸非诺多泮的制备方法
JP6026024B2 (ja) 2013-06-27 2016-11-16 ファイザー・インク 複素芳香族化合物およびそのドーパミンｄ１リガンドとしての使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4265889A (en) * 1978-05-05 1981-05-05 Smithkline Corporation 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4707483A (en) * 1985-12-20 1987-11-17 Smithkline Beckman Corporation 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
US4861771A (en) * 1989-01-27 1989-08-29 Smithkline Beckman Corporation Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs

Also Published As

Publication number Publication date
GB9903671D0 (en) 1999-04-14
CN1142916C (zh) 2004-03-24
EP1157009A1 (en) 2001-11-28
WO2000049000A1 (en) 2000-08-24
ZA200106478B (en) 2002-02-07
NO20013978D0 (no) 2001-08-15
HUP0200057A3 (en) 2004-03-29
KR20010108228A (ko) 2001-12-07
CZ20012973A3 (cs) 2002-01-16
CN1341102A (zh) 2002-03-20
AU2563200A (en) 2000-09-04
IL144810A0 (en) 2002-06-30
AU767332B2 (en) 2003-11-06
MXPA01008294A (es) 2002-07-02
PL349838A1 (en) 2002-09-23
JP2002537288A (ja) 2002-11-05
HUP0200057A2 (en) 2002-08-28
NO20013978L (no) 2001-08-15
BR0008329A (pt) 2002-01-29
CA2363695A1 (en) 2000-08-24
EA200100783A1 (ru) 2002-02-28

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU