DZ3264A1 - Inhibiteurs de thrombine a base de pyrazinone - Google Patents
Inhibiteurs de thrombine a base de pyrazinoneInfo
- Publication number
- DZ3264A1 DZ3264A1 DZ003264A DZ003264A DZ3264A1 DZ 3264 A1 DZ3264 A1 DZ 3264A1 DZ 003264 A DZ003264 A DZ 003264A DZ 003264 A DZ003264 A DZ 003264A DZ 3264 A1 DZ3264 A1 DZ 3264A1
- Authority
- DZ
- Algeria
- Prior art keywords
- pyrazinone
- thrombin inhibitors
- based thrombin
- alkyl
- halogencyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/18—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13753899P | 1999-06-04 | 1999-06-04 | |
US14429199P | 1999-07-16 | 1999-07-16 | |
PCT/US2000/015140 WO2000075134A1 (fr) | 1999-06-04 | 2000-06-01 | Inhibiteurs de thrombine a base de pyrazinone |
Publications (1)
Publication Number | Publication Date |
---|---|
DZ3264A1 true DZ3264A1 (fr) | 2000-12-14 |
Family
ID=26835338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DZ003264A DZ3264A1 (fr) | 1999-06-04 | 2000-06-01 | Inhibiteurs de thrombine a base de pyrazinone |
Country Status (31)
Country | Link |
---|---|
US (1) | US6455532B1 (fr) |
EP (1) | EP1189899B1 (fr) |
JP (2) | JP4495377B2 (fr) |
KR (1) | KR20020029653A (fr) |
CN (1) | CN1353705A (fr) |
AT (1) | ATE232527T1 (fr) |
AU (1) | AU761982B2 (fr) |
BG (1) | BG106263A (fr) |
BR (1) | BR0011260A (fr) |
CA (1) | CA2373999C (fr) |
CZ (1) | CZ20014343A3 (fr) |
DE (1) | DE60001414T2 (fr) |
DK (1) | DK1189899T3 (fr) |
DZ (1) | DZ3264A1 (fr) |
EA (1) | EA004372B1 (fr) |
EE (1) | EE200100641A (fr) |
ES (1) | ES2190417T3 (fr) |
HK (1) | HK1047277A1 (fr) |
HR (1) | HRP20010903A2 (fr) |
HU (1) | HUP0202366A3 (fr) |
IL (1) | IL146393A0 (fr) |
IS (1) | IS6158A (fr) |
MX (1) | MXPA01012505A (fr) |
NO (1) | NO20015887L (fr) |
NZ (1) | NZ515454A (fr) |
PL (1) | PL352558A1 (fr) |
SK (1) | SK17532001A3 (fr) |
TR (1) | TR200103491T2 (fr) |
UA (1) | UA58636C2 (fr) |
WO (1) | WO2000075134A1 (fr) |
YU (1) | YU84301A (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001092234A1 (fr) | 2000-06-01 | 2001-12-06 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
FR2818277B1 (fr) * | 2000-12-14 | 2003-01-24 | Servier Lab | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP2004516286A (ja) | 2000-12-18 | 2004-06-03 | メルク エンド カムパニー インコーポレーテッド | ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用 |
US6528503B2 (en) | 2000-12-18 | 2003-03-04 | Merck & Co., Inc. | Thrombin inhibitors |
CA2436176A1 (fr) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Inhibiteurs de thrombine |
WO2003048127A1 (fr) | 2001-12-04 | 2003-06-12 | Corvas International, Inc. | Inhibiteurs non covalents heterocycliques aromatiques de l'urokinase et de la formation de vaisseaux sanguins |
FR2867780B1 (fr) * | 2004-03-19 | 2006-05-19 | Servier Lab | Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE102004022897A1 (de) * | 2004-05-10 | 2005-12-08 | Bayer Cropscience Ag | Azinyl-imidazoazine |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
DE102008041214A1 (de) | 2008-08-13 | 2010-02-18 | Bayer Cropscience Ag | N-substituierte Azinylakyl-azincarboxamide und deren Analoge |
AU2010315338A1 (en) * | 2009-11-03 | 2012-05-24 | Diakron Pharmaceuticals, Inc. | Process for the preparation of pyrazinone thrombin inhibitor and its intermediates |
KR20140090663A (ko) | 2011-11-07 | 2014-07-17 | 디아크론 파마슈티칼스, 인코포레이티드 | 직접 트롬빈 억제제의 연장 방출성 제형 |
CN115677511B (zh) * | 2022-10-26 | 2024-06-21 | 南通华祥医药科技有限公司 | 一种2,2-二氟丙胺盐酸盐的合成方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0262096B1 (fr) | 1986-09-26 | 1992-01-02 | Ciba-Geigy Ag | Aminopyrazinones et aminotriazinones |
TW201303B (fr) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
GB9207145D0 (en) | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
TW197429B (fr) | 1991-05-01 | 1993-01-01 | Dtsuka Seiyaku Kk | |
DE4127404A1 (de) | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
TW223629B (fr) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
DE69431718T2 (de) | 1993-04-30 | 2003-07-10 | Merck & Co., Inc. | Thrombin-inhibitoren |
US5672582A (en) | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
AU698911B2 (en) | 1995-04-04 | 1998-11-12 | Merck & Co., Inc. | Thrombin inhibitors |
US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
WO1997001338A1 (fr) | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Inhibiteurs de la thrombine a base de pyridinone |
WO1999011267A1 (fr) * | 1997-09-05 | 1999-03-11 | Merck & Co., Inc. | Inhibiteurs de thrombine a base de pyrazinone |
SK145398A3 (en) * | 1996-04-23 | 1999-05-07 | Merck & Co Inc | Pyrazinone thrombin inhibitors |
US5668289A (en) | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US5981546A (en) | 1996-08-29 | 1999-11-09 | Merck & Co., Inc. | Integrin antagonists |
EP0971891A4 (fr) | 1997-01-22 | 2000-04-19 | Merck & Co Inc | Inhibiteurs de thrombine |
JP2001518932A (ja) | 1997-03-24 | 2001-10-16 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害薬 |
US5866573A (en) | 1997-04-21 | 1999-02-02 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
JP2002515434A (ja) * | 1998-05-19 | 2002-05-28 | メルク エンド カムパニー インコーポレーテッド | ピラジノン系トロンビン阻害薬 |
DE60019296T2 (de) | 1999-05-19 | 2006-03-09 | Pharmacia Corp., Chicago | Substituierte polyzyklische aryl und heteroarylpyrazinone zur selektiven hemmung von der blutgerinnungskaskade |
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2000
- 2000-01-06 UA UA2002010007A patent/UA58636C2/uk unknown
- 2000-06-01 DK DK00939492T patent/DK1189899T3/da active
- 2000-06-01 KR KR1020017015562A patent/KR20020029653A/ko not_active Application Discontinuation
- 2000-06-01 DE DE60001414T patent/DE60001414T2/de not_active Expired - Lifetime
- 2000-06-01 DZ DZ003264A patent/DZ3264A1/fr active
- 2000-06-01 US US09/585,112 patent/US6455532B1/en not_active Expired - Lifetime
- 2000-06-01 CZ CZ20014343A patent/CZ20014343A3/cs unknown
- 2000-06-01 YU YU84301A patent/YU84301A/sh unknown
- 2000-06-01 MX MXPA01012505A patent/MXPA01012505A/es unknown
- 2000-06-01 SK SK1753-2001A patent/SK17532001A3/sk unknown
- 2000-06-01 TR TR2001/03491T patent/TR200103491T2/xx unknown
- 2000-06-01 WO PCT/US2000/015140 patent/WO2000075134A1/fr not_active Application Discontinuation
- 2000-06-01 CA CA002373999A patent/CA2373999C/fr not_active Expired - Lifetime
- 2000-06-01 ES ES00939492T patent/ES2190417T3/es not_active Expired - Lifetime
- 2000-06-01 NZ NZ515454A patent/NZ515454A/xx not_active Application Discontinuation
- 2000-06-01 EA EA200200005A patent/EA004372B1/ru not_active IP Right Cessation
- 2000-06-01 AU AU54571/00A patent/AU761982B2/en not_active Expired
- 2000-06-01 JP JP2001502417A patent/JP4495377B2/ja not_active Expired - Fee Related
- 2000-06-01 AT AT00939492T patent/ATE232527T1/de active
- 2000-06-01 IL IL14639300A patent/IL146393A0/xx unknown
- 2000-06-01 BR BR0011260-7A patent/BR0011260A/pt not_active IP Right Cessation
- 2000-06-01 CN CN00808497A patent/CN1353705A/zh active Pending
- 2000-06-01 EE EEP200100641A patent/EE200100641A/xx unknown
- 2000-06-01 EP EP00939492A patent/EP1189899B1/fr not_active Expired - Lifetime
- 2000-06-01 HU HU0202366A patent/HUP0202366A3/hu unknown
- 2000-06-01 PL PL00352558A patent/PL352558A1/xx not_active Application Discontinuation
-
2001
- 2001-11-13 IS IS6158A patent/IS6158A/is unknown
- 2001-12-03 NO NO20015887A patent/NO20015887L/no not_active Application Discontinuation
- 2001-12-04 HR HR20010903A patent/HRP20010903A2/hr not_active Application Discontinuation
- 2001-12-21 BG BG106263A patent/BG106263A/xx unknown
-
2002
- 2002-12-05 HK HK02108849.4A patent/HK1047277A1/zh unknown
-
2010
- 2010-02-24 JP JP2010038280A patent/JP2010150275A/ja active Pending
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